Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-C-740	PF-3274167 cas:900510-03-4	Cligosiban (PF-3274167),a high oral bioavailability and good brain-penetrant non-peptide oxytocin receptor antagonist,shows a high-affinity(Ki=9.5 nM)and an excellent selectivity versus the vasopressin receptors with almost no affinity for the V1b and V1a subtypes.Cligosiban inhibits ejaculatory physiology in rodents.	price>
R-R-2639	(Rac)-Upacicalcet CAS No.2649575-19-7	(Rac)-Upacicalcet/CAS No.2649575-19-7 is the racemate of Upacicalcet.Upacicalcet is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT).	price>
R-R-2640	Gadolinium chloride CAS No.10138-52-0	Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease.	price>
R-R-2641	Cinacalcet hydrochloride CAS No.364782-34-3	Cinacalcet hydrochloride (AMG-073 hydrochloride)/CAS No.364782-34-3 is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.	price>
R-R-2642	Evocalcet CAS No.870964-67-3	Evocalcet (KHK7580)/CAS No.870964-67-3 is an orally active calcium sensing receptor (CaSR) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism.	price>
R-R-2643	Calhex 231 hydrochloride CAS No.2387505-78-2	Calhex 231 hydrochloride/CAS No.2387505-78-2 is a CaSR inhibitor via negative allosteric modulation. Calhex 231 hydrochloride blocks Ca2+-induced accumulation of [3H]inositol phosphate with an IC50 of 0.39 μM in HEK293 cells. Calhex 231 hydrochloride has the potential for diabetic cardiomyopathy (DCM) treatment.	price>
R-R-2644	NPS-2143 hydrochloride CAS No.324523-20-8	NPS-2143 hydrochloride (SB-262470A hydrochloride)/CAS No.324523-20-8, an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca2+ concentrations (IC50=43 nM) elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor.	price>
R-R-2645	Tecalcet Hydrochloride CAS No.177172-49-5	Tecalcet Hydrochloride (R 568 Hydrochloride)/CAS No.177172-49-5, an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca2+.	price>
R-R-2646	Ligustroflavone CAS No.260413-62-5	Ligustroflavone/CAS No.260413-62-5, extracted from Ligustrum lucidum, is a potential candidate as calcium-sensing receptor (CaSR) antagonist. Ligustroflavone exhibits protective effects against diabetic osteoporosis in mice.	price>
R-R-2647	Upacicalcet sodium CAS No.2052969-18-1	Upacicalcet sodium/CAS No.2052969-18-1 is an intravenous calcimimetic agent. Upacicalcet suppresses excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels, by acting directly on parathyroid cell membrane calcium-sensing receptors. Upacicalcet can be used for researching the disease of secondary hyperparathyroidism (SHPT).	price>

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