Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2658	MTEP hydrochloride CAS No.1186195-60-7	MTEP hydrochloride/CAS No.1186195-60-7 is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC50 of 5 nM and a Ki of 16 nM. MTEP hydrochloride shows antidepressant and anxiolytic-like effects.	price>
R-R-2659	(RS)-MCPG CAS No.146669-29-6	(RS)-MCPG (alpha-MCPG)/CAS No.146669-29-6 is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons.	price>
R-R-2660	JNJ16259685 CAS No.409345-29-5	JNJ16259685/CAS No.409345-29-5 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM.	price>
R-R-2661	LY367385 hydrochloride CAS No.2829282-00-8	LY367385 hydrochloride/CAS No.2829282-00-8 is a highly selective and potent mGluR1a antagonist. LY367385 hydrochloride has an IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 hydrochloride has neuroprotective, anticonvulsant and antiepileptic effects.	price>
R-R-2662	LY2794193 CAS No.2173037-97-1	LY2794193/CAS No.2173037-97-1 is a highly potent and selective mGlu3 receptor agonist (hmGlu3 Ki=0.927 nM，EC50=0.47 nM; hmGlu2 Ki=412 nM，EC50=47.5 nM).	price>
R-R-2663	LY404039 CAS No.635318-11-5	LY404039/CAS No.635318-11-5 is a potent, selective and orally active mGluR2 and mGluR3 agonist with Kis of 149 nM and 92 nM for recombinant human mGluR2 and mGluR3, respectively. LY404039 shows >100-fold selectivity for mGluR2/3 over other receptors/transproters. LY404039 has antipsychotic and anxiolytic effects.	price>
R-R-2664	(S)-MCPG CAS No.150145-89-4	(S)-MCPG ((+)-MCPG)/CAS No.150145-89-4 is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371). (S)-MCPG can be used for the study of the function of mGluRs in spatial learning.	price>
R-R-2665	MMPIP hydrochloride CAS No.1215566-78-1	MMPIP hydrochloride/CAS No.1215566-78-1 is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (KB values 24 -30 nM). MMPIP hydrochloride acts as a pharmacological tool for elucidating the roles of mGluR7 on central nervous system functions. MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice.	price>
R-R-2666	Mavoglurant CAS No.543906-09-8	Mavoglurant (AFQ056)/CAS No.543906-09-8 is a potent, selective, non-competitive and orally active mGluR5 antagonist, with an IC50 of 30 nM. Mavoglurant shows a >300 fold selectivity for the mGluR5 over all targets (238) tested. Mavoglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-2667	Dipraglurant CAS No.872363-17-2	Dipraglurant (ADX48621)/CAS No.872363-17-2 is a potent, selective, orally active and brain penetrant mGluR5 negative allosteric modulator (NAM), with an IC50 of 21 nM. Dipraglurant can reduce Levodopa-induced dyskinesia (LID) in vivo. Dipraglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>

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