ML281 CAS:1404437-62-2

ML-281 is a potent ans selective STK33 inhibitor(IC50=14 nM).ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors.ML281 is a valuable addition to small-molecule probes of STK33.v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)is the most mutated oncogene, and KRAS mutations have been found in up to 20% of all human tumors.STK33 was selectively toxic to KRAS-dependent cancer cell lines,suggesting that small-molecule inhibitors of STK33 might selectively target KRAS-dependent cancers.

msds---ML281