STF-31 CAS:724741-75-7

Glucose transporter 1(Glut1)is an inducible carrier of pentoses and hexoses, including glucose.STF-31 is an inhibitor of Glut1(IC50=~1 µM)that blocks glucose uptake.It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene,which overexpress Glut1.1 Although STF-31 binds Glut1, suggesting a direct effect,STF-31 also inhibits nicotinamide phosphoribosyltransferase,an enzyme that induces Glut1 expression.STF-31 is also toxic to human pluripotent stem cells(hPSCs)and can be used to selectively eliminate hPSCs from mixed cultures.

msds---STF-31