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R-M-162 Cyclo(-Leu-Trp),CAS:15136-34-2 The diketopiperazine cyclo(Leu-Trp) has been isolated by Minamiura et al. from casein hydrolyzate by bacterial proteinase. It is one of the bitter compounds detected in cheese. Cyclo(L-Leu-L-Trp) is a diketopiperazine metabolite originally isolated from Penicillium. It is active against various bacteria (MICs = 125-1000 µg/ml) and fungi (MICs = 8-64 µg/ml), and it inhibits the production rate of hydroxy radicals in an electron spin resonance (ESR) spectroscopy-based assay (IC50 = 1.8 µM). Cyclo(L-Leu-L-Trp) is a bitter tastant that can rapidly permeate rat taste cell membranes ex vivo when used at a concentration of 1 mM. It also acts as a melatonin receptor agonist in X. laevis melanophores, inhibiting cAMP accumulation when used at a concentration of 20 µM, an effect that is blocked by the melatonin receptor antagonist luzindole (Cay-15998). price>
R-M-203 Autocamtide-2  Peptide Autocamtide-2 is a highly selective peptide substrate for calcium/calmodulin-dependent protein kinase II (CaMKII), which belongs to the CAMK Ser/Thr protein kinase family. The sequence derives from the Thr-286 autophosphorylation site of the alpha subunit of CaMKII. Autocamtide-2 contains the R-X-X-S/T consensus site surrounded by basic residues for improved binding to phosphocellulose. CaMKII is a prominent kinase in the central nervous system that functions in long-term potentiation and neurotransmitter release. Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. CaMKII phosphorylates Autocamtide-2 with a Km of 2 uM whereas protein kinase C (PKC) has a Km > 50 uM and protein kinase A (PKA) has no activity. price>
R-M-484 Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde trifluor Acetyl-AAVALLPAVLLALLAP-IETD-CHO, the potent reversible caspase-8 inhibitor IETD-CHO is rendered cell-permeable by attaching a non-polar CPP corresponding to the Kaposi fibroblast growth factor (FGF) signal peptide sequence. price>
R-R-1584 Maduramicin ammonium CAS No.84878-61-5 Maduramicin ammonium (Maduramycin ammonium)/CAS No.84878-61-5 is isolated from the actinomycete Actinomadura rubra. Maduramicin ammonium (Maduramycin ammonium) is an anticoccidial agent for the the treatment of Eimeria spp., E. adenoeides, E. gallopavonis, and E. dispersa infection. Maduramicin ammonium (Maduramycin ammonium) induces cell apoptosis in chicken myocardial cells via intrinsic and extrinsic pathways. price>
R-OR-569 Ethylenediamine glycyrrhetinic acid Ruixi Biotechnology Co., Ltd. is a well-known biotechnology company. Our company focuses on the production and sales of scientific research level drug delivery and drug nano targeting products. At present, our products mainly include synthetic phospholipids, PEG derivatives, block copolymers, nano gold, magnetic nanoparticles, mesoporous silica, reactive fluorescent dyes, fluorescent quantum dots, click Chemistry and macrocyclic ligands, etc. price>
R-M-163 Ac-Lys-N-Me-Leu-Val-N-Me-Phe-Phe-NH₂ trifluoroacetate salt Membrane-permeable inhibitor of Aβ (1-40) fibrillogenesis.Ac-Lys-(Me)Leu-Val-(Me)Phe-Phe-NH2 (CAS# 461640-33-5) is a useful research chemical compound. price>
R-M-204 CREBtide Peptide This eptide is a synthetic substrate for protein kinase A (PKA) with a Km = 3.9 uM. The peptide sequence corresponds to residues 123-135 of human cAMP-response element-binding protein (CREB) and contains the Ser-133 phosphorylation site for CaMK1, CaMK2 and CaMK4. price>
R-R-1585 BETd-260 CAS No.2093388-62-4 BETd-260 (ZBC 260)/CAS No.2093388-62-4 is a PROTAC connected by ligands for Cereblon and BET, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line. BETd-260 potently suppresses cell viability and robustly induces apoptosis in hepatocellular carcinoma (HCC) cells. price>
R-M-164 ent-[Amyloid β-Protein (20-16)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)]) trifluoroacetate salt This all-D peptide contains two retro-inverso peptide klvff motifs of KLVF corresponding to amino acids 16 to 20 of amyloid β-protein.The tandem dimer retro-inverso peptide showed about a 100-fold higher binding affinity (Kd = 1.3 · 10⁻² µM) for amyloid β-protein (1-40) fibrils than KLVFF (Kd = 1.1 ± 0.3 µM).It was also found to be more effective in preventing ordered fibril formation than the parent peptide KLVFF as judged by its increased ability to inhibit thioflavin T binding to β-sheet structures. price>
R-M-205 [Tyr8] Substance P,CAS Number: 55614-10-3 [Tyr8] Substance P(SP),[Tyr8] Substance P from ruixi.Substance P belongs to the tachykinin family which excites neurons, provoke behaviorial responses, are potent vasodilators and secretagogues. price>
R-R-1586 Lobaplatin CAS No.135558-11-1 Lobaplatin (D-19466)/CAS No.135558-11-1 is a diastereometric mixture of platinum(II) complexe. Lobaplatin arrests cell cycle at G1 and G2/M phase. Lobaplatin induces apoptosis by increasing expressions of caspase and Bax, decreasing expression of Bcl-2. Lobaplatin can be used for research of cancer. price>
R-OR-571 Chitooligosaccharide oleic acid Ruixi Biotechnology Co., Ltd. is a well-known biotechnology company. Our company focuses on the production and sales of scientific research level drug delivery and drug nano targeting products. At present, our products mainly include synthetic phospholipids, PEG derivatives, block copolymers, nano gold, magnetic nanoparticles, mesoporous silica, reactive fluorescent dyes, fluorescent quantum dots, click Chemistry and macrocyclic ligands, etc price>
R-M-165 Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (35-40) trifluoroacetate salt,CAS:1802078-24-5 Cys-Gly-Lys-Lys-Gly-Amyloid β-Protein (35-40) trifluoroacetate salt,CAS:1802078-24-5 is a kind of amino peptides. price>
R-M-206 [tyr8] bk Peptide,Cas :32222-00-7 [Tyr8] Bradykinin Peptide, [tyr8] bk Peptide from ruixi.Bradykinin is a peptide that exhibits natriuretic, antioxidative, vasodilatory, and pro-angiogenic activities. Bradykinin stimulates bradykinin receptors and increases PLC activity, decreasing ENaC open probability, inhibiting distal nephron Na+ transport, and inducing natriuresis. In vitro, bradykinin decreases H2O2-induced senescence, increases activity of superoxide dismutase (SOD), and suppresses DNA damage, ROS production, and NADPH oxidase activity. Additionally, bradykinin increases expression of VEGF and promotes tube formation in prostate cancer cells. price>
R-R-1587 alpha-Hederin CAS No.27013-91-8 alpha-Hederin (α-Hederin)/CAS No.27013-91-8, a monodesmosidic triterpenoid saponin, exhibits promising antitumor potential against a variety of human cancer cell lines. alpha-Hederin could inhibit the proliferation and induce apoptosis of gastric cancer accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway. price>
R-C-0003 Dimethyldioctadecylammonium bromide,CAS:3700-67-2 Dimethyldioctadecylammonium bromide,DODAB,DDAB from ruixi. Dimethyldioctadecylammonium bromide is a synthetic double chain cationic surfactant with a simple structure similar to phospholipid, the main component of cell membrane. Therefore, DODAB and its analogues are often used to simulate the biochemical process of biofilm. price>
R-M-166 Extracellular Death Factor trifluoroacetate salt,CAS:960129-66-2 EDF is a quorum-sensing factor for mazEF-mediated cell death in E.coli. It may be a lead for a new class of antibiotics that specifically trigger bacterial cell death.Extracellular death factor (EDF) is a linear pentapeptide that activates the cell death pathway in a subset of communicating cells. Programmed cell death in bacteria is dependent on a system of cell-to-cell communication termed quorum sensing. It is sensitive to extreme pH, high temperatures, and other cellular stress. EDF has been shown to trigger cell death at 2.5 ng/ml which significantly reduces population size in some E. coli cultures. price>
R-M-207 [Tyr4] Bombesin Peptide,CAS:67338-70-9 Bombesin, secreted by the toad skin glands, stimulates smooth muscle contraction. price>
R-R-1588 bpV(phen) trihydrate CAS No.171202-16-7 bpV(phen) trihydrate/CAS No.171202-16-7, a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) trihydrate can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity. price>
R-OR-572 P(DMA-co-TPAMA) All hydrophilic block polymer is a kind of special amphiphilic block polymer, which is composed of two or more blocks with different chemical properties, and each block has water solubility under appropriate conditions. price>