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R-R-1638 Didesmethylrocaglamide CAS No.177262-30-5 Didesmethylrocaglamide/CAS No.177262-30-5, a derivative of Rocaglamide, is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. Didesmethylrocaglamide has potent growth-inhibitory activity with an IC50 of 5 nM. Didesmethylrocaglamide suppresses multiple growth-promoting signaling pathways and induces apoptosis in tumor cells. Antitumor activity. price>
R-M-258 NaYF4:Yb,Tm@NaYF4(PEG-NH2 modified core-shell ucnps ,980 excitation, blue light) NaYF4:Yb,Tm@NaYF4 is a PEG-NH2 modified core-shell upconversion nanoparticles (980 excited, blue light).Material composition: NaYF4:Yb,Tm@NaYF4 .The particle size was 30-40, the concentration was 2 mg / ml, the excitation wavelength was 980 nm, the emission wavelength was 365 / 450 / 470 nm ± 15 nm (green light), and the surface ligand was PEG-NH2. price>
R-M-274 Urotensin I,Cas:83930-33-0 Urotensin-I was first isolated from the urophysis of the white sucker, and has been shown to decrease blood pressure in the rat. The type-2 CRH receptor has a high affinity with UI compared to CRH. UI stimulates adrenocorticotropic hormone (ACTH) release. UI is involved in the adaptability of fishes regarding, for example, ion and fluid equilibrium, cardiovascular activity, and inter-renal tissue glucocorticoid release.Urotensin is found in the teleost caudal neurosecretory system. It has a suggested role in osmoregulation and as a corticotropin-releasing factor. price>
R-R-1639 RWJ-56110 dihydrochloride CAS No.2387505-58-8 RWJ-56110 dihydrochloride/CAS No.2387505-58-8 is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 (HY-108566). RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell apoptosis. price>
R-M-259 NaYF4,Yb,Er@NaYF4,Yb,Nd(PEG-NH2 modified core-shell ucnps ,808 excitation, green light) NaYF4,Yb,Er@NaYF4 Yb, nd is PEG-NH2 modified core-shell upconversion nanoparticles (808 excitation, green light),material composition: NaYF4,Yb,Er@NaYF4 Yb, Nd. particle size 30-40, concentration 2mg/ml, excitation wavelength 808nm, emission wavelength 540/650nm ± 15 nm (green light), surface ligand is PEG-NH2. price>
R-M-265 Cyclo(-Pro-Thr) ,CAS: 227777-31-3 Cyclo(-Pro-Thr) (CAS:227777-31-3) is a useful research chemical compound. price>
R-M-276 Ucn III,cas:357952-10-4 Urocortin-3 is a protein that in humans is encoded by the UCN3 gene.It belongs to the corticotropin-releasing hormone family.Urocortin III decreases food intake and delays gastric emptying activity. Stresscopin is a specific ligand for the corticotropin-releasing hormone receptor type 2 (CRHR2), therefore acts as the endogenous ligand for maintaining homeostasis after stress. Urocortin III corresponds to Stresscopin . price>
R-R-1640 Lucidenic acid B CAS No.95311-95-8 Lucidenic acid B/CAS No.95311-95-8 is a natural compound isolated from Ganoderma lucidum, induces apoptosis of cancer cells, and causes the activation of caspase-9 and caspase-3, and cleavage of PARP. Lucidenic acid B does not affect the cell cycle profile, or the number of necrotic cells. price>
R-M-260 NaYF4,Yb,Tm@NaYF4 Yb, nd(PEG-NH2 modified core-shell ucnps ,808 excitation, blue light) NaYF4,Yb,Tm@NaYF4 Yb, nd is PEG-NH2 modified core-shell upconversion nanoparticles (808 excitation, blue light),material composition: NaYF4,Yb,Tm@NaYF4 .The results showed that the optimum conditions were as follows: Yb, Nd, particle size 30-40, concentration 2 mg / ml, excitation wavelength 808 nm, emission wavelength 365 / 450 / 470 nm ± 15 nm (blue light), surface ligand PEG-NH2. price>
R-M-266 Cyclo(-Gly-Phe),CAS :10125-07-2 Cyclo(-Gly-Phe),CAS :10125-07-2 is used to study the thermodynamics of protein unfolding. It is also able to cause gelation in a wide variety of organic fluids, including edible oils, glyceryl esters, alcohols, and aromatic molecules. price>
R-M-277 TRH Free Acid Peptide TRH free acid is derived from Thyrotropin Releasing Hormone (TRH), and the latter could cause the release of Thyroid Stimulating Hormone (TSH) from the pituitary . They are different functionally, such as stimulation of GTPase depended on occupancy of the TRH receptor; half-maximal increases in GTPase activity required 46 nM TRH and 25 nM [N3-methyl-His]TRH, but the TRH free acid was inactive.Regulates the synthesis of TRH in the Pituitary gland and acts as a neurotransmitter in the nervous system. price>
R-R-1641 Ajoene CAS No.92285-01-3 Ajoene/CAS No.92285-01-3, a garlic-derived compound, is an antithrombotic and antifungal agent. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Anticancer activities. price>
R-M-267 Cyclo(-Ala-Gly),CAS:4526-77-6 Cyclo(-Ala-Gly),CAS:4526-77-6 from ruixi.Diketopiperazine and monoalkyldiketopiperazines such as cyclo-(Ala-Gly) and cyclo-(Gly-Leu) underwent a stereocontrolled transannular rearrangement (after activation by N-acylation or N-Bocylation) yielding 4-hydroxy-3-pyrrolin-2-ones. price>
R-M-278 TP508 Peptide ,CAS:121341-81-9 TP508 is a 23 amino acid synthetic peptide representing residues 508-530 of human prothrombin which is identified as a potential receptor-binding domain based on competition for high-affinity thrombin binding to fibroblasts. price>
R-R-1642 Reveromycin A CAS No.134615-37-5 Reveromycin A/CAS No.134615-37-5, a benzoquinoid antibiotic isolated from the genus Streptomyces, is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity. price>
R-M-268 Cyclo(-Gly-Gly),CAS:106-57-0 Cyclo(-Gly-Gly),2,5-Piperazinedione(CAS:106-57-0)can be used as an intermediate in the preparation of various pharmaceutical and biologically active compounds. It can be used in the synthesis of dipeptide isosteres by cross-metathesis. price>
R-M-279 TNF-alpha Tumor necrosis factor alpha (TNF-alpha) is a cytokine that binds to the TNF-R1 and TNF-R2 receptors. TNF-alpha is mainly secreted by macrophages and induces cell death of certain tumor cell lines. It is a potent pyrogen causing fever by direct action or by stimulation of IL-1 secretion, and therefore found in cachexia accompanying diverse cancers and infections. Genetic variations in TNF are associated with susceptibility to psoriatic arthritis and to HBV infection. price>
R-R-1643 3-Dehydrotrametenolic acid CAS No.29220-16-4 3-Dehydrotrametenolic acid/CAS No.29220-16-4, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-Dehydrotrametenolic acid induces apoptosis and has anticancer activity. price>
R-M-269 Cyclo(-Gly-Trp) ,CAS :7451-73-2 Cyclo(-Gly-Trp),Cyclo(-glycyl-tryptophyl) from ruixi.Cyclo(glycyltryptophyl) is a member of indoles. It has a role as a metabolite. price>
R-M-280 TLR4 Peptide Toll-like receptor family (TLR) has a fundamental role in pathogen recognition and activation of innate immunity. TLRs recognize pathogen-associated molecular patterns (PAMP) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 acts via MYD88, TIRAP and TRAF6 to lead to NFkB activation, cytokine secretion and inflammatory response. TLR4 is highly expressed in placenta, spleen and peripheral blood leukocytes. price>