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Catalog	name	Description	price
R-R-2155	Liensinine Diperchlorate CAS No.5088-90-4	Liensinine Diperchlorate/CAS No.5088-90-4 is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc.	price>
R-C-456	Dibenzazepine (YO-01027) CAS:209984-56-5	Yo-01027 is a dipeptide type γ-secretase inhibitor with IC50 of 2.6 nm and 2.9 nm,respectively.Yo-01027 is an anti Alzheimer drug.Yo-01027 interacts directly with γ-secretase complex.Different from other γ-secretase inhibitors,yo-01027 targets different functional domains of the complex.Yo-01027 targets the N-terminal presenilin fragment and another gamma secretase inhibitor compound E(CPN E),while dfk167 and dapt bind to the catalytic sites of presenilin aspartate protease subunit and C-terminal presenilin fragment,respectively.In one study,yo-01027 and cpne showed no significant difference in blocking appl and notch cleavage,indicating that the IC50 values of the two substrates were statistically equal.	price>
R-R-2156	Chloroquine-d5 CAS No.1854126-41-2	Chloroquine-d5/CAS No.1854126-41-2 is deuterium labeled Chloroquine. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).	price>
R-C-457	Gedatolisib（PKI587） CAS:1197160-78-3	Gedatolisib (pf-05212384,pki-587) is a highly effective dual inhibitor of PI3K α,PI3K γ and mTOR.The IC50 of gedatolisib (pf-05212384,pki-587) is 0.4nm,5.4nm and 1.6nm in cell-free experiment,respectively.Pki-587 also showed potency against the most common PI3K mutation, especially h1047r and e545k,with IC50 of 0.6Nm and 0.6Nm,respectively.The inhibitory effect of pf-05212384 on PI3Ks and mtors inhibited the growth of mda-361 and pc3-mm2 cell lines with IC50 of 4 nm and 13.1 nm,respectively.	price>
R-R-2157	RSVA405 CAS No.140405-36-3	RSVA405/CAS No.140405-36-3 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity.	price>
R-C-458	LY2886721 CAS:1262036-50-9	Ly2886721 is a bace inhibitor for the treatment of Alzheimer disease.The IC50 of recombinant hbace-1 was 20.3 nm.Human BACE2 was inhibited by IC50 of 10.2 nm.It did not inhibit other aspartic proteases,such as cathepsin D,pepsin and renin.A potential drug for Alzheimer disease.The IC50 values of a β 1-40 and a β 1-42 were 18.5 nm and 19.7 nm,respectively,in HEK-293 swe cells and PDAPP neurons (IC50 ~ 10 nm).	price>
R-R-2158	Crustecdysone CAS No.5289-74-7	Crustecdysone (20-Hydroxyecdysone)/CAS No.5289-74-7 is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system. Crustecdysone is an active metabolite of Ecdysone (HY-N0179).	price>
R-C-459	GSK690693 CAS:937174-76-0	Gsk690693 is a pan Akt inhibitor targeting AKT1/2/3.The IC50 of gsk690693 is 2 nm /13nm/9 nm in cell-free analysis.Gsk690693 is also sensitive to pKa,PrKX and PKC isozymes of AGC kinase family.Gsk690693 also inhibited AMPK and dapk3 of CaMK family with IC50 of 50nm and 81nm,respectively.	price>
R-R-2159	Autophagy inducer 3 CAS No.2691054-63-2	Autophagy inducer 3/CAS No.2691054-63-2 has autophagy induced activity. Autophagy inducer 3 possesses robust autophagic cell death in diverse cancer cells sparing normal counterpart. Autophagy inducer 3 induces lethal autophagy by formation of characteristic autophagic vacuoles, LC3 puncta formation, upregulation of signature autophagy markers like Beclin and Atg family proteins.	price>
R-C-460	PF-04691502 CAS:1013101-36-4	PF-04691502 (PF4691502) is an ATP-competitive PI3K(α/β/δ/γ)/mTOR dual inhibitor with Ki of 1.8 nM/2.1 nM/1.6 nM/1.9 nM and 16 nM in cell-free assays, little activity against either Vps34, AKT, PDK1,p70S6K,MEK,ERK,p38,or JNK. PF-04691502 induces apoptosis.	price>
R-R-2160	AUTEN-67 CAS No.1783800-77-0	AUTEN-67 (Autophagy enhancer-67)/CAS No.1783800-77-0 is an orally active autophagy enhancer and MTMR14 inhibitor. AUTEN-67 has anti-aging and neuroprotective effects. AUTEN-67 protects neurons from stress-induced cell death. AUTEN-67 also restores nesting behavior in a mice model of Alzheimer disease.	price>
R-C-461	SRT1720 CAS:1001645-58-4	SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM,and shows less potent activities agaiinst SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM,respectively.	price>
R-R-2161	Vps34-IN-4 CAS No.1383716-46-8	Vps34-IN-4 (compound 19)/CAS No.1383716-46-8 is a potent, selective, and orally active inhibitor of VPS34. Vps34-IN-4 inhibits the autophagy in vivo. Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components.	price>
R-C-462	PP242 CAS:1092351-67-1	Torkinib (PP242) is a selective mTOR inhibitor with IC50 of 8 nM in cell-free assays;targets both mTOR complexes with>10-and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ,respectively.Torkinib (PP242) induces mitophagy and apoptosis.	price>
R-R-2162	mTOR inhibitor-8 CAS No.2489196-70-3	mTOR inhibitor-8/CAS No.2489196-70-3 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells.	price>
R-C-463	KW-2478 cas:819812-04-9	KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.	price>
R-R-2163	Rapamycin-d3 CAS No.392711-19-2	Rapamycin-d3/CAS No.392711-19-2 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific mTOR inhibitor with an IC50of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.	price>
R-C-464	YM201636 cas:371942-69-7	YM-201636 is a potent and selective PIKfyve inhibitor with an IC50 of 33 nM. YM-201636 also inhibits p110α with an IC50 of 3.3 μM.YM-201636 inhibits retroviral replic.	price>
R-R-2164	Corynoxine CAS No.6877-32-3	Corynoxine/CAS No.6877-32-3, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway.	price>
R-C-465	ms-275 CAS:209783-80-2	Entinostat (MS-275, SNDX-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays,compared with HDACs 4,6,8,and 10.Entinostat induces autophagy and apoptosis.MS 275 is also offered as part of the Tocriscreen 2.0 Max,Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library.	price>

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