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Catalog	name	Description	price
R-R-2165	ATG7-IN-2 CAS No.2226227-75-2	ATG7-IN-2 (compound 1)/CAS No.2226227-75-2 is a potent ATG7 inhibitor, with an IC50 of 0.089 μM. ATG7-IN-2 inhibits autophagy marker LC3B.	price>
R-C-466	PI-103 cas:371935-74-9	PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM in cell-free assays,less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM.PI-103 induces apoptosis in murine T-cell Lymphoma.	price>
R-R-2166	GPP78 CAS No.1202580-59-3	GPP78 (CAY10618)/CAS No.1202580-59-3 is a potent Nampt inhibitor with an IC50 of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects.	price>
R-C-467	PKI-402 cas:1173204-81-3	PKI-402 is a potent dual pan-PI3K/mTOR inhibitor targeting PI3Kα/β/γ/δ and mTOR with IC50 of 2 nM/7 nM/16 nM/14 nM and 3 nM,respectively;also potent to PI3Kα mutants E545K and H1047R.	price>
R-R-2167	MRT67307 CAS No.1190378-57-4	MRT67307/CAS No.1190378-57-4 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells.	price>
R-C-468	GDC0980 CAS:1032754-93-0	GDC-0980 selectively inhibits the activities against class I PI3K and mTOR kinase with a Ki of 17 nM for mTOR (FRAP) and IC50 of 5 nM,27 nM,7nM,and 14 nM for PI3Kα,β,δ,and γ,respectively. GDC-0980 significantly inhibits cell proliferation in PC3 and MCF7 cells.	price>
R-R-2168	EN6 CAS No.1808714-73-9	EN6/CAS No.1808714-73-9 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase. EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag, leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy. EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner.	price>
R-C-469	GSK1292263 CAS:1032823-75-8	GSK-1292263 is an orally available GPR119 agonist with pEC50s of 6.9 and 6.7 for human and rat GPR119,respectively. GSK-1292263 can be used for the research of type 2 diabetes mellitus(T2DM).GSK1292263 is a novel GPR119 agonist, showing potential for the treatment of type 2 diabetes.	price>
R-R-2169	S29434 CAS No.874484-20-5	S29434 (NMDPEF)/CAS No.874484-20-5 is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 induces autophagy and inhibits QR2-mediated ROS production.	price>
R-C-470	PHA665752 CAS:477575-56-7	PHA-665752 is a selective,ATP-competitive,and active-site inhibitor of the catalytic activity of c-Met kinase (Ki=4 nM;IC50=9 nM).PHA-665752 exhibits >50-fold selectivity for c-Met compared with a panel of diverse tyrosine and serine-threonine kinases.PHA-665752 induces apoptosis and cell cycle arrest,and exhibits cytoreductive antitumor activity.	price>
R-R-2170	SBP-7455 CAS No.1884222-74-5	SBP-7455/CAS No.1884222-74-5 is a potent, high affinity and orally active dual ULK1/ULK2 autophagy inhibitor with IC50s of 13 nM and 476 nM in the ADP-Glo assays, respectively. SBP-7455 potently inhibits ULK1/2 enzymatic activity and can be used for triple-negative breast cancer (TNBC) research.	price>
R-C-471	Tasisulam(LY573636) CAS:519055-63-1	LY573636 is a potent anti-tumor agent,which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo.LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.	price>
R-R-2171	6-CEPN CAS No.1054549-73-3	6-CEPN/CAS No.1054549-73-3 is a RAS inhibitor. 6-CEPN can inhibit RAS activation by binding to Icmt binding sites. 6-CEPN has anticancer activity. 6-CEPN can block cancer cells in the G1 phase. 6-CEPN can induce autophagy and necrosis of Cancer cells (Icmt: isovalerylcysteine carboxymethyltransferase).	price>
R-C-472	AZD8055 CAS:1009298-09-2	AZD8055 is a novel ATP-competitive mTOR inhibitor with IC50 of 0.8 nM in MDA-MB-468 cells with excellent selectivity(∼1,000-fold) against PI3K isoforms and ATM/DNA-PK.AZD8055 induces caspase-dependent apoptosis and also induces autophagy.	price>
R-R-2172	ATG7-IN-3 CAS No.2226229-76-9	ATG7-IN-3 (compound 18)/CAS No.2226229-76-9 is a potent ATG7 inhibitor, with an IC50 of 0.048 μM. ATG7-IN-3 inhibits autophagy. ATG7-IN-3 inhibits the formation of endogenous LC3B puncta in the neuroglioma cell line H4.	price>
R-C-473	KU0063794 CAS:938440-64-3	KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2 with IC50 of 10 nM in cell-free assays;no effect on PI3Ks.KU-0063794 is a selective inhibitor of mammalian target of rapamycin (mTOR)(IC50 10 nM for mTORC1 and mTORC2 respectively).	price>
R-R-2173	CC214-2 CAS No.1228012-18-7	CC214-2/CAS No.1228012-18-7 is an oral active and selective mTOR kinase inhibitor. CC214-2 targets to both of mTORC1 (pS6) and mTORC2 (pAktS473). CC214-2 induces autophagy, which is a potential target for host-directed therapy (HDT) in tuberculosis. CC214-2 exhibits synergistic bactericidal and sterilizing activity agasinst tuberculosis (TB), and shortens the treatment duration. CC214-2 also inhibits Rapamycin (HY-10219)-resistant signaling and the growth of glioblastomas in vitro and in vivo.	price>
R-C-474	Enzalutamide (MDV3100) CAS:915087-33-1	MDV3100 is androgen-receptor inhibitor.Highly recommended inhibitor in AR research.Enzalutamide(MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM in LNCaP cells.Enzalutamide is shown to increase autophagy.	price>
R-R-2174	ICCB-19 hydrochloride CAS No.1803605-68-6	ICCB-19 hydrochloride/CAS No.1803605-68-6 is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride is indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and the degradation of long-lived proteins.	price>
R-C-475	AST-1306 CAS:897383-62-9	AST-1306,a novel anilino-quinazoline compound,inhibits the enzymatic activities of wild-type epidermal growth factor receptor(EGFR)and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems.It is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM,also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.	price>

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