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Catalog	name	Description	price
R-R-2175	20-Deoxyingenol CAS No.54706-99-9	20-Deoxyingenol/CAS No.54706-99-9, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA).	price>
R-C-476	Apixaban CAS:503612-47-3	Apixaban(BMS 562247-01) is a highly selective,reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit,respectively.Apixaban is an anticoagulant for the prevention of venous thromboembolism and venous thromboembolic events.	price>
R-R-2176	Atg4B-IN-2 CAS No.2765008-88-4	Atg4B-IN-2/CAS No.2765008-88-4 is a potent competitive Atg4B inhibitor with Ki value of 3.1 μM, also possesses declining PLA2 inhibitory potency, IC50s of 11 μM and 3.5 μM for Atg4B and PLA2, respectively. Atg4B-IN-2 enhances the anticancer activity of anti-castration-resistant prostate cancer agents via autophagy inhibition.	price>
R-C-477	MGCD0103 CAS:726169-73-9	MGCD0103(Mocetinostat)is a benzamide histone deacetylase inhibitor by inhibiting mainly histone deacetylase 1(HDAC1),but also HDAC2,HDAC3,and HDAC11.It is a potent HDAC inhibitor with most potency for HDAC1 with IC50 of 0.15 μM in a cell-free assay, 2-to10-fold selectivity against HDAC2,3,and 11,and no activity to HDAC4,5,6,7,and 8.Mocetinostat (MGCD0103) induces apoptosis and autophagy.	price>
R-R-2177	P62-mediated mitophagy inducer CAS No.1809031-84-2	P62-mediated mitophagy inducer (PMI)/CAS No.1809031-84-2 is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential.	price>
R-C-478	Foretinib(XL880) CAS:849217-64-7	Foretinib(GSK1363089,EXEL-2880,XL-880) is an ATP-competitive inhibitor of HGFR and VEGFR,mostly for Met (c-Met)and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays.Less potent against Ron,Flt-1/3/4,Kit (c-Kit), PDGFRα/β and Tie-2,and little activity to FGFR1 and EGFR.	price>
R-R-2178	HDAC10-IN-1	HDAC10-IN-1 (compound 13b) is a potent and highly selective HDAC10 inhibitor, with an IC50 of 58 nM. HDAC10-IN-1 modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells.	price>
R-C-479	Glesatinib(MGCD265) CAS:875337-44-3	MGCD265 is a multitargeted tyrosine kinase inhibitor that binds to and inhibits the phosphorylation of several RTKs,including the c-Met receptor (HGFR);the Tek/Tie-2 receptor;VEGFR types 1,2,and 3;and MST1R.	price>
R-R-2179	HDAC10-IN-2 hydrochloride	HDAC10-IN-2 hydrochloride (compound 10c) is a potent and highly selective HDAC10 inhibitor, with an IC50 of 20 nM. HDAC10-IN-2 hydrochloride modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells.	price>
R-C-480	Roscovitine (Seliciclib) CAS:186692-46-6	Roscovitine (Seliciclib,CYC202) is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM,0.7 μM and 0.16 μM in cell-free assays.It shows little effect on CDK4/6.	price>
R-R-2180	Daurisoline CAS No.70553-76-3	Daurisoline/CAS No.70553-76-3 is a hERG inhibitor and also an autophagy blocker.	price>
R-C-481	sns032 CAS:345627-80-7	SNS-032(BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10-and 20-fold selective over CDK1/CDK4.It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6.SNS-032 (BMS-387032) induces apoptosi.	price>
R-R-2181	Thonningianin B CAS No.271579-12-5	Thonningianin B/CAS No.271579-12-5 is an antioxidant and an autophagy enhancer.	price>
R-C-482	ABT-263(Navitoclax) CAS:923564-51-6	ABT-263 also called Navitoclax is a potent and orally bioavailable Bcl-2 family inhibitor (Ki of <1 nmol/L for Bcl-2,Bcl-xL,and Bcl-w).it maintains a high affinity for Bcl-xL,Bcl-2,and Bcl-w,(Ki ≤1 nmol/L),but binds more weakly to Mcl-1 and A1.	price>
R-R-2182	Tat-beclin 1 CAS No.1423821-88-8	Tat-beclin 1/CAS No.1423821-88-8, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV).	price>
R-C-483	ABT-737 cas:852808-04-9	ABT-737 is a pan-Bcl-2 inhibitor.IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10μM (Nalm-6,K562 and HL-60).	price>
R-R-2183	Metformin-d6 hydrochloride CAS No.1185166-01-1	Metformin-d6 (hydrochloride)/CAS No.1185166-01-1 is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin hydrochloride triggers autophagy.	price>
R-C-484	NVP-BGJ398 cas:872511-34-7	Infigratinib(BGJ-398; NVP-BGJ398) is a potent inhibitor of the FGFR family with IC50s of 0.9 nM,1.4 nM,1 nM,and 60 nM for FGFR1,FGFR2,FGFR3,and FGFR4, respectively.	price>
R-R-2184	Pennogenin 3-O-beta-chacotrioside CAS No.55916-52-4	Pennogenin 3-O-beta-chacotrioside/CAS No.55916-52-4 is an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1. Anti-colorectal cancer activity.	price>
R-C-485	BAY73-4506(Regorafenib) cas:755037-03-7	Regorafenib (BAY73-4506,Fluoro-Sorafenib,Resihance,Stivarga) is a multi-target inhibitor for VEGFR1,VEGFR2,VEGFR3,PDGFRβ,Kit (c-Kit),RET (c-RET) and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM,22 nM,7nM,1.5 nM and 2.5 nM in cell-free assays,respectively.Regorafenib induces autophag.	price>

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