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Catalog	name	Description	price
R-R-2185	Aumitin CAS No.946293-78-3	Aumitin/CAS No.946293-78-3 is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively.	price>
R-C-486	Roflumilast,Daxas cas:162401-32-3	Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7,0.9,0.7,and 0.2 nM for PDE4A1,PDEA4,PDEB1,and PDEB2,respectively,without affecting PDE1,PDE2, PDE3 or PDE5 isoenzymes from various cells.	price>
R-R-2186	Paclitaxel-d5 (benzoyloxy) CAS No.1261254-56-1	Paclitaxel-d5 (benzoyloxy)/CAS No.1261254-56-1 is the deuterium labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.	price>
R-C-487	Fasudil hydrochloride cas:105628-07-7	Fasudil Hydrochloride (HA-1077 Hydrochloride;AT877 Hydrochloride),is a nonspecific ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1,IC50s of 0.158 μM and 4.58 μM,12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively.Fasudil Hydrochloride is also a potent Ca2+channel antagonist and vasodilator.	price>
R-R-2187	3BDO CAS No.890405-51-3	3BDO/CAS No.890405-51-3 is a new mTOR activator which can also inhibit autophagy.	price>
R-C-488	Pelitinib(EKB-569) cas:257933-82-7	Pelitinib(EKB-569;WAY-EKB 569)is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM;also slightly inhibits Src,MEK/ERK and ErbB2 with IC50s of 282,800,and 1255 nM,respectively.	price>
R-R-2188	Obeticholic acid-d5 CAS No.1992000-80-2	Obeticholic acid-d5/CAS No.1992000-80-2 is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy.	price>
R-C-489	Neratinib(HKI-272) cas:698387-09-6	Neratinib(HKI-272)is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays;weakly inhibits KDR and Src,no significant inhibition to Akt,CDK1/2/4,IKK-2,MK-2,PDK1,c-Raf and c-Met.	price>
R-R-2189	Obeticholic Acid-d4	Obeticholic Acid-d4 is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy.	price>
R-C-490	Imatinib cas:152459-95-5	Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL,v-Abl,PDGFR and c-kit kinase activity.Imatinib (STI571) works by binding close to the ATP binding site,locking it in a closed or self-inhibited conformation,therefore inhibiting the enzyme activity of the protein semicompetitively.Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.	price>
R-R-2190	Venetoclax-d8 CAS No.1257051-06-1	Venetoclax-d8/CAS No.1257051-06-1 is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy.	price>
R-C-491	Erlotinib HCL cas:183319-69-9	Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved.Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor.For the signal to be transmitted,two EGFR molecules need to come together to form a homodimer.These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues,which generates phosphotyrosine residues,recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processesWhen erlotinib binds to EGFR,formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.	price>
R-R-2191	SMER18 CAS No.944153-47-3	SMER18/CAS No.944153-47-3 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.	price>
R-C-492	Afatinib(BIBW2992) cas:439081-18-2	BIBW2992(Afatinib)is tyrosine kinase inhibitor(TKI)that irreversibly inhibits human epidermal growth factor receptor 2(Her2)and epidermal growth factor receptor(EGFR) kinases.	price>
R-R-2192	CA-5f CAS No.1370032-19-1	CA-5f/CAS No.1370032-19-1 is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. CA-5f increases LC3B-II (a marker to monitor autophagy) and SQSTM1 protein, and also increases ROS production. Anti-tumor activity.	price>
R-C-493	PCI-32765 cas:936563-96-1	Ibrutinib (PCI-32765) is a potent and highly selective Brutons tyrosine kinase (Btk)inhibitor with IC50 of 0.5 nM in cell-free assays,modestly potent to Bmx, CSK,FGR,BRK,HCK,less potent to EGFR Yes,ErbB2,JAK3etc.Ibrutinib is applicable as a Btk ligand in the synthesis of a series of PROTACs including P13I.	price>
R-R-2193	Elaiophylin CAS No.37318-06-2	Elaiophylin (Azalomycin B; Gopalamicin; Efomycin E)/CAS No.37318-06-2 is an autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells.	price>
R-C-494	AP24534(Ponatinib) cas:943319-70-8	Ponatinib(AP24534)is a novel,potent multi-target inhibitor of Abl,PDGFRα, VEGFR2,FGFR1 and Src with IC50 of 0.37 nM,1.1 nM,1.5 nM,2.2 nM and 5.4 nM in cell-free assays,respectively.Ponatinib (AP24534) inhibits autophagy.	price>
R-R-2194	Nortriptyline hydrochloride CAS No.894-71-3	Nortriptyline (Desmethylamitriptyline) hydrochloride/CAS No.894-71-3, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects.	price>
R-C-495	AT101 CAS:90141-22-3	AT101,the R-(-) enantiomer of Gossypol acetic acid,binds with Bcl-2,Bcl-xL and Mcl-1 with Ki of 0.32μM,0.48μM and 0.18μM.	price>

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