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Catalog	name	Description	price
R-R-2195	UBCS039 CAS No.358721-70-7	UBCS039/CAS No.358721-70-7 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM.	price>
R-C-496	AZD5438 cas:602306-29-6	AZD-5438 is a potent CDK1,CDK2,and CDK9 inhibitor,with IC50s of 16 nM,6 nM,and 20 nM in cell-free assays,respectively.AZD-5438 shows less inhibition activity against GSK3β,CDK5 and CDK6 .	price>
R-R-2196	Nortriptyline CAS No.72-69-5	Nortriptyline (Desmethylamitriptyline)/CAS No.72-69-5, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects.	price>
R-C-497	CX-4945 CAS:1009820-21-6	Silmitasertib(CX-4945) is a potent and selective inhibitor of CK2(casein kinase 2)with IC50 of 1 nM in a cell-free assay,less potent to Flt3,Pim1 and CDK1 (inactive in cell-based assay).Silmitasertib induces autophagy and promotes apoptosis.	price>
R-R-2197	Desethyl chloroquine CAS No.1476-52-4	Desethyl chloroquine/CAS No.1476-52-4 is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity.	price>
R-C-498	LY2109761 cas:700874-71-1	LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM in a cell-free assay,respectively;shown to negatively affect the phosphorylation of Smad2.LY2109761 blocks autophagy and induces apoptosis.	price>
R-R-2198	S130 CAS No.1160852-22-1	S130/CAS No.1160852-22-1 is a high affinity, selective inhibitor of ATG4B (a major cysteine protease) with an IC50 of 3.24 µM. S130 suppresses autophagy flux.	price>
R-C-499	RAF265 cas:927880-90-8	RAF265(CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM,and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays.RAF265 (CHIR-265)induces cell cycle arrest and apoptosis.	price>
R-R-2199	Wogonoside CAS No.51059-44-0	Wogonoside/CAS No.51059-44-0, a flavonoid glycoside isolated from Huangqin, possesses anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating MAPK-mTOR pathway.	price>
R-C-500	LY294002 cas:154447-36-6	LY294002 (SF 1101,NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/βwith IC50 of 0.5 μM/0.57 μM/0.97 μM,respectively;more stable in solution than Wortmannin,and also blocks autophagosome formation.It not only binds to class I PI3Ks and other PI3K-related kinases,but also to novel targets seemingly unrelated to the PI3K family.LY294002 also inhibits CK2 with IC50 of 98 nM.LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.	price>
R-R-2200	Dehydropachymic acid CAS No.77012-31-8	Dehydropachymic acid/CAS No.77012-31-8 is one of the major triterpenes isolated from Poria cocos. Dehydropachymic acid is more effective in autophagy-lysosome pathway (ALP) impaired cells rather than normal cells.	price>
R-C-501	KU55933 cas:587871-26-9	KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays,and is highly selective for ATM as compared to DNA-PK,PI3K/PI4K,ATR and mTOR.KU55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy initiating kinase ULK1 and results in a significant decrease of autophagy.	price>
R-R-2201	Syringin CAS No.118-34-3	Syringin (Eleutheroside B)/CAS No.118-34-3 is an active natural phenolic glycoside possessing various pharmacological activities, including anti-inflammatory, anti-irradiation, anti-osteoporosis and anticancer activities. Syringin also can be used to enhance memory, relieve fatigue, improve human cognition and protect ischemia heart against cerebrovascular damage, etc.	price>
R-C-502	Cabozantinib (XL184，BMS-907351) cas:849217-68-1	Cabozantinib (XL184,BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met,Ret,Kit,Flt-1/3/4,Tie2,and AXL with IC50 of 1.3 nM,4 nM,4.6 nM,12 nM/11.3 nM/6 nM,14.3 nM and 7 nM in cell-free assays, respectively.Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway.	price>
R-R-2202	Ginkgolide K CAS No.153355-70-5	Ginkgolide K/CAS No.153355-70-5, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Ginkgolide K possesses neuroprotective activity.	price>
R-R-2203	Desethyl chloroquine diphosphate CAS No.247912-76-1	Desethyl chloroquine diphosphate/CAS No.247912-76-1 is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine diphosphate possesses antiplasmodic activity.	price>
R-C-504	FUB359 cas:184025-18-1	Ciproxifan maleate (FUB 359 maleate) is a potent,selective,orally bioavailable and competitive antagonist of histamine H3-receptor,with an IC50 of 9.2 nM. Ciproxifan maleate displays low apparent affinity at other receptor subtypes. Ciproxifan maleate can be used for the research of aging disorders and Alzheimer disease.	price>
R-R-2204	Zingiberene CAS No.495-60-3	Zingiberene (α-Zingiberene)/CAS No.495-60-3 is a monocyclic sesquiterpene which is the predominant constituent of ginger with oil content (Zingiber officinale). Neuroprotective potential. Zingiberene triggers autophagy. Anticancer activity.	price>
R-C-505	Canetinib cas:267243-28-7	Canertinib(CI-1033,PD183805)is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM,no activity to PDGFR, FGFR,InsR,PKC,or CDK1/2/4.	price>
R-R-2205	Glyburide-d3 CAS No.1219803-02-7	Glyburide-d3/CAS No.1219803-02-7 is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR). Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability. Glibenclamide can induce autophagy.	price>

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