Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-C-516	ARN-509 cas:956104-40-8	ARN-509 is an androgen receptor antagonist with potential antineoplastic activity.ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus.This prevents binding to and transcription of AR-responsive genes.	price>
R-R-2216	AS1842856 CAS No.836620-48-5	AS1842856/CAS No.836620-48-5, a specific inhibitor of Foxo1 (IC50=30 nM), potently suppresses autophagy. AS1842856 inhibits FoxO1 activity by suppressing SIRT1 expression. AS1842856 only reduces FoxO1 activity by binding to it, without affecting its transcription and protein expression.	price>
R-C-517	OC000459 cas:851723-84-7	Timapiprant (OC000459) is a potent,selective,and orally active D prostanoid receptor 2 (DP2,also known as CRTH2) antagonist.Timapiprant (OC000459)potently displaces [3H] PGD2 from human recombinant DP2(Ki=13 nM),rat recombinant DP2(Ki=3 nM),and human native DP2(Ki=4 nM).Timapiprant (OC000459) inhibits mast cell activation of Th2 lymphocytes and eosinophils.	price>
R-R-2217	(Rac)-BL-918 CAS No.2435589-07-2	(Rac)-BL-918/CAS No.2435589-07-2 is the racemate of BL-918. BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1), inducing cytoprotective autophagy for Parkinsonism disease treatment.	price>
R-C-518	HQL-79 cas:162641-16-9	HQL-79 is a selective inhibitor of hematopoietic prostaglandin D (PGD) synthase, that structurally is a synthetic tetrazole compound originally prepared as a possible antihistamine.	price>
R-R-2218	Metformin CAS No.657-24-9	Metformin (1,1-Dimethylbiguanide)/CAS No.657-24-9 inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin can cross the blood-brain barrier and triggers autophagy.	price>
R-C-519	JTT-705 (Dalcetrapib) cas:211513-37-0	JTT-705(Dalcetrapib) is a CETP inhibitor.Inhibition of CETP is a target to increase HDL-cholesterol and potentially reduce atherosclerosis.	price>
R-R-2219	3,4-Dimethoxychalcone CAS No.5416-71-7	3,4-Dimethoxychalcone/CAS No.5416-71-7 is a Caloric restriction mimetics (CRMs). 3,4-Dimethoxychalcone induces the deacetylation of cytoplasmic proteins and stimulates autophagy flux. 3,4-Dimethoxychalcone can be used for cardiac and cancer diseases research.	price>
R-C-520	MK-5108(VX689) cas:1010085-13-8	MK-5108(VX-689)is a highly selective Aurora A inhibitor with IC50 of 0.064 nM in a cell-free assay and is 220- and 190-fold more selective for Aurora A than Aurora B/C,while it inhibits TrkA with less than 100-fold selectivity.MK-5108 (VX-689) induces autophagy.	price>
R-R-2220	Desethyl chloroquine-d4 CAS No.1189971-72-9	Desethyl chloroquine-d4/CAS No.1189971-72-9 is the deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity.	price>
R-C-521	LY2811376 cas:1194044-20-6	LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM,that act to decrease Aβ secretion with EC50 of 300 nM,demonstrated to have 10-fold selectivity towards BACE1 over BACE2,and more than 50-fold inhibition over other aspartic proteases including cathepsin D,pepsin, or renin.	price>
R-R-2221	ALLO-1 CAS No.37468-32-9	ALLO-1/CAS No.37468-32-9, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif.	price>
R-C-522	CTEP (RO4956371) CAS:871362-31-1	CTEP(RO4956371)is a novel,long-acting,orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM,shows >1000-fold selectivity over other mGlu receptors.	price>
R-R-2222	FeTMPyP CAS No.133314-07-5	FeTMPyP/CAS No.133314-07-5 is an orally active peroxynitrite (ONOO?) scavenger. FeTMPyP reduces nitrative stress and increases autophagy. FeTMPyP reduces PARP over-activation and neuroinflammation in chronic constriction injury (CCI)-induced rats, and ameliorates functional, behavioral and biochemical deficits.	price>
R-C-523	PF-02341066 cas:877399-52-5	Crizotinib(PF-02341066)is an orally bioavailable,ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively.Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays,respectively.Crizotinib is also a ROS1 inhibitor.Crizotinib has effective tumor growth inhibition.	price>
R-R-2223	Chelerythrine chloride CAS No.3895-92-9	Chelerythrine chloride/CAS No.3895-92-9 is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.	price>
R-C-524	Vonoprazan Fumarate (TAK-438)	Vonoprazan Fumarate (TAK-438) is a novel P-CAB(potassium-competitive acid blocker)that reversibly inhibits H+/K+,ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion.	price>
R-R-2224	Retro-2 CAS No.1201652-50-7	Retro-2/CAS No.1201652-50-7 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 µM in HeLa cells. Retro-2 induces cell autophagy.	price>
R-C-525	Nedocromil cas:69049-73-6	Nedocromil suppresses the action or formation of multiple mediators,including histamine,leukotriene C4 (LTC4),and prostaglandin D2(PGD2).	price>
R-R-2225	Onjisaponin B CAS No.35906-36-6	Onjisaponin B/CAS No.35906-36-6 is a natural product derived from Polygala tenuifolia. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells, and exbibits potential therapeutic effects on Parkinson disease and Huntington disease.	price>

425426427428429430 431432433434435