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Catalog	name	Description	price
R-C-526	IOX2 cas:931398-72-0	IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2(PHD2) with IC50 of 21 nM in a cell-free assay,100-fold selectivity over JMJD2A,JMJD2C,JMJD2E,JMJD3,or the 2OG oxygenase FIH.	price>
R-R-2226	Ambroxol CAS No.18683-91-5	Ambroxol (NA-872)/CAS No.18683-91-5, an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.	price>
R-C-527	GNF-2 cas:778270-11-4	GNF-2 is a highly selective non-ATP competitive inhibitor of Bcr-Abl,shows no activity to Flt3-ITD,Tel-PDGFR,TPR-MET and Tel-JAK1 transformed tumor cells.	price>
R-R-2227	Ambroxol hydrochloride CAS No.23828-92-4	Ambroxol hydrochloride (NA-872 hydrochloride)/CAS No.23828-92-4, an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.	price>
R-C-528	THIACETAZONE cas:104-06-3	Thiabendazole inhibits the mitochondrial helminth-specific enzyme,fumarate reductase,with anthelminthic property,used as an anthelmintic and fungicide agent. It is a potent inhibitor of cytochrome P450 1A2 (CYP1A2).	price>
R-R-2228	Phellodendrine chloride CAS No.104112-82-5	Phellodendrine chloride/CAS No.104112-82-5 is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis . Phellodendrine chloride promotes autophagy by regulating the AMPK/mTOR pathway and reduce the intestinal damage of ulcerative colitis.	price>
R-C-529	PD0325901 cas:391210-10-9	Mirdametinib(PD0325901) is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays,roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2.	price>
R-R-2229	Olaparib-d8	Olaparib-d8 is the deuterium labeled Olaparib (AZD2281). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator.	price>
R-C-530	R406 cas:841290-80-0	R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM,potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM,measured at an ATP concentration corresponding to its Km value.R406 reduces immune complex-mediated inflammation.R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).	price>
R-R-2230	Spironolactone-d7	Spironolactone-d7 is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes.	price>
R-C-531	AT-406 cas:1071992-99-8	AT406(SM-406,ARRY-334543, Debio1143) is a potent Smac mimetic and an antagonist of IAP(inhibitor of apoptosis protein via E3 ubiquitin ligase),binding to XIAP-BIR3,cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM,1.9 nM,and 5.1 nM,50-to 100-fold higher affinities than the Smac AVPI peptide.	price>
R-R-2231	TFEB activator 1 CAS No.39777-61-2	TFEB activator 1/CAS No.39777-61-2 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment.	price>
R-C-532	R547 cas:741713-40-6	R547 is a novel,selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs)(Ki = 1,3,and 1 nM for CDK1,CDK2,and CDK4,respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines.	price>
R-R-2232	Dorsomorphin dihydrochloride CAS No.1219168-18-9	Dorsomorphin dihydrochloride (BML-275 dihydrochloride; Compound C dihydrochloride)/CAS No.1219168-18-9 is an AMPK inhibitor that is potent, selective, and ATP-competitive, with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits the BMP pathway by targeting the type I receptors ALK2, ALK3 and ALK6. Dorsomorphin dihydrochloride induces autophagy.	price>
R-C-533	CB-7598 cas:154229-19-3	Abiraterone(CB-7598) inhibits 17 α-hydroxylase/C17,20 lyase (CYP17A1),an enzyme which is expressed in testicular,adrenal, and prostatic tumor tissues.	price>
R-R-2233	Typhaneoside CAS No.104472-68-6	Typhaneoside/CAS No.104472-68-6, extracted from Typha angustifolia L., Typhaneoside can inhibit the excessive autophagy of hypoxia/reoxygenation cells and increase the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering blood lipid levels, promoting antiatherosclerosis activities, as well as improving immune and coagulation function.	price>
R-C-534	Abiraterone Acetate(CB7630) cas:154229-18-2	Abiraterone acetate (CB7630) is an oral,potent,selective, and irreversible inhibitor of CYP17A1 with antiandrogen activity.Abiraterone acetate is a prodrug form of Abiraterone (CB7598).	price>
R-R-2234	Olaparib-d4-1 CAS No.2143107-55-3	Olaparib-d4-1/CAS No.2143107-55-3 is the deuterium labeled Olaparib. Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator.	price>
R-C-535	R788 cas:901119-35-5	R788(Fostamatinib)is an important spleen tyrosine kinase(Syk)inhibitor,showing efficacy against kinase-mediated IgG Fc gamma receptor signaling.	price>
R-R-2235	QX77 CAS No.1798331-92-6	QX77/CAS No.1798331-92-6 is a chaperone-mediated autophagy (CMA) activator and upregulates LAMP2A expression in vitro. QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells. QX77 can impede self-renewal and promote differentiation of ES cells.	price>

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