Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-C-536	VU0364439 cas:1246086-78-1	VU0364439 is a positive allosteric modulator(PAM)of mGlu4 receptors(EC50=19.8 nM in vitro for human mGlu4).	price>
R-R-2236	Chloroquine CAS No.54-05-7	Chloroquine/CAS No.54-05-7 is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).	price>
R-C-537	TDZD-8 cas:7036-89-5	TDZD-8 is an inhibitor of GSK-3β,with an IC50 of 2 μM;TDZD-8 shows less potent activities against Cdk-1/cyclin B, CK-II,PKA,and PKC,with all IC50s of >100 μM.	price>
R-R-2237	Ambroxol-d5 hydrochloride CAS No.2741380-71-0	Ambroxol-d5 (hydrochloride)/CAS No.2741380-71-0 is the deuterium labeled Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.	price>
R-C-538	VU0361737 cas:1161205-04-4	VU 0361737 is a selective positive allosteric modulator(PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors,respectively,displays weak activity at mGlu5 and mGlu8 receptors,is inactive at mGlu1,mGlu2,mGlu3,mGlu6 and mGlu7 receptors,can penetrate into CNS.	price>
R-R-2238	N6-Isopentenyladenosine CAS No.7724-76-7	N6-Isopentenyladenosine (Riboprine)/CAS No.7724-76-7, an RNA modification found in cytokinins, which regulate plant growth/differentiation, and a subset of tRNAs, where it improves the efficiency and accuracy of translation. N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with an interesting anti-melanoma activity.	price>
R-C-539	TCS PIM-1 4a CAS: 438190-29-5	TCS PIM-1 4a is a selective and ATP-competitive Pim kinase inhibitor(IC50 values=24 and 100 nM for Pim-1 and Pim-2,respectively).	price>
R-R-2239	Taurine-13C2 CAS No.70155-54-3	Taurine-13C2/CAS No.70155-54-3 is the 13C-labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes.	price>
R-C-540	YS-49 cas:132836-42-1	YS-49 is a PI3K/Akt(a downstream target of RhoA)activator,to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells.YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1.YS-49 is also an isoquinoline compound alkaloid,has a strong positive inotropic action through activation of cardiac β-adrenoceptors.	price>
R-R-2240	Fascaplysin CAS No.114719-57-2	Fascaplysin/CAS No.114719-57-2 is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity.	price>
R-C-541	YM-90K hydrochloride cas:154164-30-4	YM90K hydrochloride is an antagonist of AMPA receptor.	price>
R-R-2241	PHY34 CAS No.2130033-55-3	PHY34/CAS No.2130033-55-3 is an inhibitor that inhibits ATP6V0A2 and CAS thereby inhibiting autophagy, and has a nanomolar effect. PHY34 inhibits cancer cell growth by inducing apoptosis and inhibits tumor growth in xenograft models. PHY34 can be used for research on high grade serous ovarian cancer.	price>
R-C-542	Tiplaxtinin (PAI-039) CAS 393105-53-8	Tiplaxtinin(PAI-039)is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1(PAI-1) with IC50 of 2.7 uM.	price>
R-R-2242	Dorsomorphin CAS No.866405-64-3	Dorsomorphin (Compound C)/CAS No.866405-64-3 is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).	price>
R-C-543	Dapivirine (TMC120) CAS 244767-67-7	Dapivirine(TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM,inhibits a broad panel of HIV-1 isolates from different classes,inclucing a wide range of NNRTI-resistant isolates.	price>
R-R-2243	SAR405 CAS No.1523406-39-4	SAR405/CAS No.1523406-39-4 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM). SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition. Anticancer activity.	price>
R-C-544	WZ 811 CAS 55778-02-4	WZ811 is an orally active, highly potent competitive antagonist of CXCR4.WZ811 efficiently inhibits CXCR4/SDF-1(or CXCL12)-mediated modulation of cAMP levels (EC50=1.2 nM) and SDF-1 induced Matrigel invasion in cells (EC50=5.2 nM).	price>
R-R-2244	Wortmannin CAS No.19545-26-7	Wortmannin (SL-2052; KY-12420)/CAS No.19545-26-7 is a potent, selective, and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50 of 5.8 and 48 nM, respectively.	price>
R-C-545	TTP 22 CAS 329907-28-0	TTP 22 is a high affinity,ATP-competitive casein kinase 2(CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM, and shows selectivity >250-fold for CK2 over JNK3,ROCK1, and MET(IC50> 10 uM).	price>
R-R-2245	Felodipine-d3 CAS No.1219795-30-8	Felodipine-d3/CAS No.1219795-30-8 is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier.	price>

427428429430431432 433434435436437