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Catalog	name	Description	price
R-C-546	AG-490 CAS: 134036-52-5	AG-490(Tyrphostin AG 490) is an inhibitor of EGFR (IC50: 0.1μM).It is 135-fold more selective for EGFR than ErbB2,also inhibits JAK2 with no effect to Lyn,Lck, Syk,Btk,and Src.	price>
R-R-2246	Ethyl pyruvate CAS No.617-35-6	Ethyl pyruvate/CAS No.617-35-6 is a simple derivative of the endogenous metabolite pyruvate. Ethyl pyruvate is an HMGB1 release inhibitor. Ethyl pyruvate can induce apoptosis by autophagy. Ethyl pyruvate has anti-inflammatory, antioxidant and anti-tumor activity.	price>
R-R-2247	Felodipine-d5 CAS No.1242281-38-4	Felodipine-d5/CAS No.1242281-38-4 is deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier.	price>
R-C-548	DY131 CAS: 95167-41-2	DY131(GSK 9089) is a potent and selective ERRγ and ERRβ agonist.DY131displays inactive against ERRα,ERα and ERβ.DY131 also inhibits Smo signaling.	price>
R-R-2248	FDW028 CAS No.2768426-49-7	FDW028/CAS No.2768426-49-7 a potent and highly selective FUT8 inhibitor. FUT8 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the chaperone-mediated autophagy (CMA) pathway. FDW028 can be used for metastatic colorectal cancer (mCRC) research.	price>
R-C-549	GW788388 CAS: 452342-67-5	GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM in a cell-free assay,also inhibits TGF-βtype II receptor and activin type II receptor activities,but does not inhibit BMP type II receptor.	price>
R-R-2249	Brefeldin A CAS No.20350-15-6	Brefeldin A (BFA)/CAS No.20350-15-6 is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from the endoplasmic reticulum to the Golgi apparatus. Brefeldin A is also an inhibitor of autophagy and mitophagy. Brefeldin A is a CRISPR/Cas9 activator. Brefeldin A inhibits HSV-1 and has anti-cancer activity.	price>
R-C-550	Pyridone 6 CAS:457081-03-7	Pyridone 6(CMP 6)is a potent and selective inhibitor of JAK1 (IC50=15 nM,murine JAK1),JAK2 (IC50=1 nM),JAK3 (Ki=5 nM),and Tyk2 (IC50=1 nM);displaying significantly weaker affinities (130 nM to 10 mM) for other protein tyrosine kinases.	price>
R-R-2250	Everolimus-d4 CAS No.1338452-54-2	Everolimus-d4/CAS No.1338452-54-2 is the deuterium labeled Everolimus. Everolimus (RAD001) is a Rapamycin derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities.	price>
R-C-551	(NSC 42834)JAK2 Inhibitor V Z3 CAS :195371-52-9	NSC 42834(JAK2 Inhibitor V,Z3) is a novel specific inhibitor of Jak2,inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.	price>
R-R-2251	EIPA hydrochloride CAS No.1345839-28-2	EIPA hydrochloride (L593754 hydrochloride)/CAS No.1345839-28-2 is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also inhibits Na+/H+ exchangers (NHE) and macropinocytosis.	price>
R-C-552	KU14R CAS:189224-48-4	KU14R is a new I(3)-R antagonist,which selectively blocks the insulin secretory response to imidazolines.	price>
R-R-2252	PD146176 CAS No.4079-26-9	PD146176 (NSC168807)/CAS No.4079-26-9, a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.	price>
R-C-553	LDN-211904 CAS:1198408-39-7	A pyrazolo[1,5-a] pyridine derivative,as an effective and reversible inhibitor of EphB3 receptor tyrosine kinase,has good stability and water solubility in mouse liver microsomes with IC50 of 79 nm.EphB3 induced autophosphorylation of EphB3 receptor was inhibited in 10 μ M cells.	price>
R-R-2253	Evogliptin tartrate CAS No.1222102-51-3	Evogliptin (DA-1229) tartrate/CAS No.1222102-51-3 is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin tartrate also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin tartrate can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation.	price>
R-C-554	MK 886 CAS: 118414-82-7	MK-886 is an inhibitor of leukotriene biosynthesis,inhibiting 5-lipoxygenase-activating protein (FLAP).It is also a moderately potent PPARα antagonist.	price>
R-R-2254	Taurine-13C2,15N CAS No.2483830-42-6	Taurine-13C2,15N/CAS No.2483830-42-6 is the 13C- and 15N- labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes.	price>
R-C-555	TAC-101 CAS:125973-56-0	Amsilarotene inhibits the phosphorylation of retinoblastoma gene product(RB) and increases the presence of 2 cyclin-dependent kinases(CDK)inhibitors resulting in cell cycle arrest.This agent also causes a cytotoxic decline in the thymidylate synthase and cyclin A expression.	price>
R-R-2255	Bromhexine-d3 hydrochloride	Bromhexine-d3 (hydrochloride) is deuterium labeled Bromhexine (hydrochloride). Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions.	price>
R-C-556	3-Methyladenine (3-MA) cas:5142-23-4	3-Methyladenine (3-MA,NSC 66389) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM in HeLa cells;blocks class I PI3K consistently,whereas suppression of class III PI3K is transient,and also blocks autophagosome formation.3-Methyladenine(3-MA)is successfully used to suppress mitophagy.	price>

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