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Catalog	name	Description	price
R-R-2256	Imipramine hydrochloride CAS No.113-52-0	Imipramine hydrochloride/CAS No.113-52-0 is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects.	price>
R-C-557	PHT427 cas:1191951-57-1	PHT-427 is a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.	price>
R-R-2257	EIPA CAS No.1154-25-2	EIPA (L593754)/CAS No.1154-25-2 is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+ exchangers (NHE) and macropinocytosis.	price>
R-C-558	GW7647 cas:265129-71-3	GW7647 is a potent PPARαagonist,with EC50s of 6 nM,1.1μM,and 6.2μM for human PPARα,PPARγ and PPARδ,respectively.	price>
R-R-2258	Dasatinib monohydrate CAS No.863127-77-9	Dasatinib (BMS-354825) monohydrate/CAS No.863127-77-9 is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib monohydrate inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively. Dasatinib monohydrate also induces apoptosis and autophagy.	price>
R-C-559	LY364947 cas:396129-53-6	LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM,and exhibits 7-fold selectivity over TGFβR-II.	price>
R-R-2259	SB 202190 hydrochloride CAS No.350228-36-3	SB 202190 hydrochloride/CAS No.350228-36-3 is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38 kinase with a Kd of 38 nM. SB 202190 hydrochloride has anti-cancer activity. SB202190 hydrochloride induces autophagy.	price>
R-C-560	SB203580 cas:152121-47-6	SB203580(RWJ 64809)is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively.SB 203580 inhibits LCK,GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38.SB 203580 does not disrupt JNK activity and is an autophagy and mitophagy activator.	price>
R-R-2260	LYN-1604 dihydrochloride CAS No.2310109-38-5	LYN-1604 dihydrochloride/CAS No.2310109-38-5 is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC).	price>
R-C-561	ZM323881 cas:324077-30-7	ZM323881 inhibits VEGF-A-induced endothelial cell proliferation (IC50=8 nM) and VEGF-R2 tyrosine phosphorylation(IC50Vascular endothelial growth factor(VEGF) increases vascular permeability and angiogenesis in many pathological conditions, such as cancer,arthritis,and diabetes.VEGF activates VEGF-Receptor 1(VEGF-R1)and VEGF-Receptor 2(VEGF-R2)that autophosphorylate to initiate a signaling cascade resulting in angiogenesis and increased microvascular permeability.ZM323881 is a potent and selective inhibitor of VEGF-R2 tyrosine kinase.	price>
R-R-2261	Pemetrexed CAS No.137281-23-3	Pemetrexed (LY231514)/CAS No.137281-23-3 is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.	price>
R-C-562	ZM306416 cas:690206-97-4	ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt,respectively.ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM.	price>
R-R-2262	AG490 CAS No.133550-30-8	AG490 (Tyrphostin AG490)/CAS No.133550-30-8 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.	price>
R-C-563	PF8380 cas:1144035-53-9	Pf-8380 is an effective automatic classification inhibitor with IC (50) of 2.8 nm in isolated enzyme assay and 101 nm in human blood.	price>
R-R-2263	Coumermycin A1 CAS No.4434-05-3	Coumermycin A1/CAS No.4434-05-3 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria. Coumermycin A1 shows anti-orthopoxvirus activity.	price>
R-C-564	RITA (NSC 652287) cas:213261-59-7	RITA(NSC 652287)induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks,and also inhibits MDM2-p53 interaction by targeting p53.	price>
R-R-2264	SJ1008030 TFA CAS No.2863634-97-1	SJ1008030 (compound 8) TFA/CAS No.2863634-97-1 is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 TFA inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 TFA can be used for the research of leukemia.	price>
R-C-565	ACY-1215 cas:1316214-52-4	Ricolinostat (ACY-1215,Rocilinostat)is a selective HDAC6 inhibitor with IC50 of 5 nM in a cell-free assay.It is>10-fold more selective for HDAC6 than HDAC1/2/3(class I HDACs)with slight activity against HDAC8,minimal activity against HDAC4/5/7/9/11,Sirtuin1,and Sirtuin2.Ricolinostat (ACY-1215)suppresses cell proliferation and promotes apoptosis.	price>
R-R-2265	Ruxolitinib phosphate CAS No.1092939-17-7	Ruxolitinib phosphate (INCB018424 phosphate)/CAS No.1092939-17-7 is a potent JAK1/2 inhibitor with IC50s of 3.3 nM/2.8 nM, respectively, showing more than 130-fold selectivity over JAK3.	price>
R-C-566	ASP3026 cas:1097917-15-1	ASP3026 is a potent,selective and orally active inhibitor of anaplastic lymphoma kinase(ALK).ASP3026 induces apoptosis of tumor cells.ASP3026 can be used for the research of non-small cell lung cancer (NSCLC).	price>

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