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Catalog	name	Description	price
R-R-2266	Ritlecitinib CAS No.1792180-81-4	Ritlecitinib/PF-06651600/CAS No.1792180-81-4 is an orally active and selective JAK3 inhibitor with an IC50 of 33.1 nM.	price>
R-C-567	sch900776 cas:891494-63-6	SCH900776(MK-8776) is a potent,selective and orally bioavailable inhibitor of checkpoint kinase1(Chk1) with an IC50 of 3 nM.SCH900776 shows 50-and 500-fold selectivity over CDK2 and Chk2,respectively.	price>
R-R-2267	Butyzamide CAS No.1110767-45-7	Butyzamide/CAS No.1110767-45-7 is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay.	price>
R-C-568	CP-945598 cas:686347-12-6	Otenabant(CP-945598) HCl is a potent and selective cannabinoid receptor CB1 antagonist with Ki of 0.7 nM,exhibits 10,000-fold greater selectivity against human CB2 receptor.	price>
R-R-2268	RO8191 CAS No.691868-88-9	RO8191 (CDM-3008)/CAS No.691868-88-9, an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon. RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity.	price>
R-C-569	OSI-027 cas:936890-98-1	OSI-027(ASP4786)is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM in cell-free assays, and more than 100-fold selectivity observed for mTOR than PI3Kα,PI3Kβ,PI3Kγ or DNA-PK.OSI-027 induces autophagy in cancer cells.	price>
R-R-2269	CHZ868 CAS No.1895895-38-1	CHZ868/CAS No.1895895-38-1 is a type II JAK2 inhibitor with an IC50 of 0.17 μM in EPOR JAK2 WT Ba/F3 cell.	price>
R-C-570	SB431542 cas:301836-41-9	SB 431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I ALK receptors ALK4,ALK5,and ALK7.	price>
R-R-2270	JAK2 JH2 Tracer CAS No.2101955-00-2	JAK2 JH2 Tracer (Tracer 5)/CAS No.2101955-00-2 is a fluorescent probe for JAK2 JH2 domain, with a Kd of value 0.2 μM.	price>
R-C-571	Tenovin-1 cas:380315-80-0	Tenovin-1,a p53 activator,protects p53 from MDM2-mediated degradation.Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also a dihydroorotate dehydrogenase(DHODH)inhibitor.	price>
R-R-2271	Baricitinib phosphate CAS No.1187595-84-1	Baricitinib phosphate (LY3009104 phosphate; INCB028050 phosphate)/CAS No.1187595-84-1 is a selective orally bioavailable JAK1/JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, respectively.	price>
R-C-572	Apoptosis Activator 2 cas:79183-19-0	Apoptosis Activator 2 strongly induces caspase-3 activation,PARP cleavage,and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM,inactive to HMEC,PREC,or MCF-10A cells.	price>
R-R-2272	Atractylenolide I CAS No.73069-13-3	Atractylenolide I/CAS No.73069-13-3 is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent.	price>
R-C-573	HA14-1 cas:65673-63-4	HA14-1 is a small,cell-permeable nonpeptidic ligand that binds to the Bcl-2 surface pocket and blocks its biological action.HA14-1 induces apoptosis in HL-60 leukemic cells overexpressing Bcl-2 and in NIH 3T3 cells via the activation of caspases by a mechanism that is distinct from Fas-mediated apoptosis.	price>
R-R-2273	Zasocitinib CAS No.2272904-53-5	Zasocitinib (NDI-034858)/CAS No.2272904-53-5 is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM.	price>
R-C-574	SMI-4a cas:327033-36-3	SIM-4a is a Pim kinase inhibitor that blocks mTORC1 activity via activation of AMPK.Mostly potent to Pim-2,does not significantly inhibit any other serine/threonine-or tyrosine-kinases.	price>
R-R-2274	Delgocitinib CAS No.1263774-59-9	Delgocitinib (JTE-052)/CAS No.1263774-59-9 is a specific JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively.	price>
R-C-575	Emtricitabine cas:143491-57-0	Emtricitabine is a nucleoside reverse transcriptase inhibitor(NRTI) with an EC50 of 0.01 µM in PBMC cell.It is an antiviral drug for the treatment of HIV infection.	price>
R-R-2275	Decernotinib CAS No.944842-54-0	Decernotinib/CAS No.944842-54-0 is a potent, orally active JAK3 inhibitor, with Kis of 2.5, 11, 13 and 11 nM for JAK3, JAK1, JAK2, and TYK2, respectively.	price>
R-C-576	TWS119 cas:601514-19-6	TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay;capable of inducing neuronal differentiation and may be useful to stem cell biology. GSK-3β inhibition triggers autophagy.	price>

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