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Catalog	name	Description	price
R-R-2286	Gusacitinib CAS No.1425381-60-7	Gusacitinib (ASN-002)/CAS No.1425381-60-7 is a dual inhibitor of spleen tyrosine kinase (SYK) and janus kinase (JAK) that is orally active and potent with IC50 values of 5-46 nM. Gusacitinib has anticancer activity in both solid and hematologic tumor types.	price>
R-C-587	Amrubicin cas:110267-81-7	Amrubicin is a synthetic anthracycline antibiotic.It inhibits DNA topoisomerase II. Antineoplastic.	price>
R-R-2287	Tyk2-IN-5 CAS No.1797432-62-2	Tyk2-IN-5 (compound 6)/CAS No.1797432-62-2 is a potent, selective and orally active tyrosine kinase 2 (Tyk2) inhibitor that acts on the JH2 structural domain. Tyk2-IN-5 shows a Ki value of 0.086 nM for Tyk2 JH2 and an IC50 value of 25 nM for IFNα. Tyk2-IN-5 efficiently inhibits the production of IFNγ in a pharmacodynamic rat model and is fully efficacious in a rat model of arthritis.	price>
R-C-588	WAY362450 cas:629664-81-9	WAY-362450 is a highly potent, selective,and orally bioavailable farnesoid X receptor(FXR)agonist (EC50:4 nM,eff=149%).	price>
R-R-2288	Momelotinib sulfate CAS No.1056636-06-6	Momelotinib sulfate (CYT387 sulfate salt)/CAS No.1056636-06-6 is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, 10-fold selectivity versus JAK3 (IC50=155 nM).	price>
R-C-589	AZD8931 cas:848942-61-0	Sapitinib(AZD8931)is a reversible,ATP competitive inhibitor of EGFR,ErbB2 and ErbB3 with IC50 of 4 nM,3 nM and 4 nM in cell-free assays,more potent than Gefitinib or Lapatinib against NSCLC cell,100-fold more selective for the ErbB family than MNK1 and Flt.	price>
R-R-2289	VVD-118313 CAS No.2875046-27-6	VVD-118313 (compound 5a)/CAS No.2875046-27-6 is a potent, selective JAK1 inhibitor. VVD-118313 targets an isoform-restricted allosteric cysteine to block JAK1-dependent trans-phosphorylation and cytokine signaling. VVD-118313 can be used for research of cancer. VVD-118313 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-590	Dabigatran etexilate cas:872728-81-9	Dabigatran etexilate(BIBR 1048)is an orally active prodrug of Dabigatran. Dabigatran etexilate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation.	price>
R-R-2290	BD750 CAS No.892686-59-8	BD750/CAS No.892686-59-8, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively.	price>
R-C-591	Lersivirine（UK 453061） cas:473921-12-9	Lersivirine(UK-453,061)is a next-generation nonnucleoside reverse transcriptase inhibitor,active against wild-type HIV-1 and several nonnucleoside reverse transcriptase inhibitor-resistant strains.	price>
R-R-2291	Povorcitinib CAS No.1637677-22-5	Povorcitinib (INCB54707)/CAS No.1637677-22-5 is a potent and selective JAK1 inhibitor that effectively reduces abscesses and inflammatory nodules. Povorcitinib is used to study cutaneous lupus erythematosus (CLE) and lichen planus (LP) (information extracted from patent WO2021076124A1).	price>
R-R-2292	JAK2-IN-6 CAS No.353512-04-6	JAK2-IN-6/CAS No.353512-04-6, a multiple-substituted aminothiazole derivative, is a potent and selective JAK2 inhibitor with an IC50 of 22.86 μg/mL. JAK2-IN-6 shows no activity against JAK1 and JAK3. JAK2-IN-6 has anti-proliferative effect against cancer cells.	price>
R-C-593	Pictilisib (GDC-0941) cas:957054-30-7	Pictilisib (GDC-0941,RG7321) is a potent inhibitor of PI3Kα/δwith IC50 of 3 nM in cell-free assays,with modest selectivity against p110β(11-fold) and p110γ(25-fold).Pictilisib (GDC-0941) induces autophagy and apoptosis.	price>
R-R-2293	Broussonin E CAS No.90902-21-9	Broussonin E/CAS No.90902-21-9 is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis.	price>
R-C-594	ABT-199 cas:1257044-40-8	Venetoclax (ABT-199,GDC-0199)is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays,4800-fold more selective versus Bcl-xL and Bcl-w,and no activity to Mcl-1.Venetoclax is reported to induce cell growth suppression,apoptosis,cell cycle arrest,and autophagy in triple negative breast cancer MDA-MB-231 cells.	price>
R-R-2294	Itacnosertib CAS No.1628870-27-8	Itacnosertib (TP-0184)/CAS No.1628870-27-8 is both inhibitor to JAK2, ACVR1 (ALK2) and ALK5 as described in WO2014151871.	price>
R-C-595	TG101348 cas:936091-26-8	Fedratinib(SAR302503,TG101348)is a selective inhibitor of JAK2 with IC50 of 3 nM in cell-free assays,35-and 334-fold more selective for JAK2 versus JAK1 and JAK3.Fedratinib also inhibits FMS-like tyrosine kinase 3(FLT3)and RET (c-RET)with IC50 of 15 nM and 48 nM,respectively. Fedratinib has potential antineoplastic activity.Fedratinib inhibits proliferation and induces apoptosis.	price>
R-R-2295	TyK2-IN-2 CAS No.2098466-94-3	TyK2-IN-2 (Compoud 18)/CAS No.2098466-94-3 is a TYK2 inhibitor that is potent and selective with IC50s of 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα, respectively. TyK2-IN-2 also inhibits phosphodiesterase 4 (PDE4) with an IC50 of 62 nM. TyK2-IN-2 can be used for research of inflammatory and autoimmune diseases.	price>
R-C-596	AGI-5198 cas:1355326-35-0	AGI-5198,also know as IDH-C35,is the a very potent and selective mutant IDH1 inhibitor that was shown to potential anticancer activity.	price>
R-R-2296	SJ10542 CAS No.2789678-92-6	SJ10542/CAS No.2789678-92-6 is a potent and selective JAK2/3 directing phenyl glutarimide (PG)-PROTAC with DC50s of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. SJ10542 utilizes a PG ligand as the cereblon (CRBN) recruiter.	price>

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