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Catalog	name	Description	price
R-C-597	XL647 cas:781613-23-8	XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization,including EGFR,HER2,ERBB2,VEGFR and EphB4.	price>
R-R-2297	ZM39923 hydrochloride CAS No.1021868-92-7	ZM39923 hydrochloride/CAS No.1021868-92-7 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 hydrochloride also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.	price>
R-C-598	Catharanthine sulfate cas:70674-90-7	Catharanthine is a natural compound isolated from Catharanthus roseus.It exhibits antitumor activity.	price>
R-R-2298	Cerdulatinib hydrochloride CAS No.1369761-01-2	Cerdulatinib hydrochloride (PRT062070)/CAS No.1369761-01-2 is a selective, oral active and reversible ATP-competitive inhibitor of dual SYK and JAK, with IC50s of 32 nM, 0.5 nM, 12 nM, 6 nM and 8 nM for SYK and Tyk2, JAK1, 2, 3, respectively. Cerdulatinib hydrochloride could be used to research autoimmune disease and B-cell malignancies.	price>
R-C-599	Vilazodone cas:163521-12-8	Vilazodone(EMD-68843,SB-659746A) is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity.The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine(Ki=56 nM)and dopamine (Ki=37 nM) sites.	price>
R-R-2299	DTP3 CAS No.1809784-29-9	DTP3 TFA/CAS No.1809784-29-9 is a potent and selective GADD45β/MKK7 inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway.	price>
R-C-600	Celecoxib cas:169590-42-5	Celecoxib(SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells.	price>
R-R-2300	Londamocitinib CAS No.2241039-81-4	Londamocitinib (AZD4604; JAK1-IN-7)/CAS No.2241039-81-4 is a Janus-associated kinase 1 (JAK1) inhibitor extracted from patent WO2018134213A1, Example 63, has an anti-inflammatory effect.	price>
R-C-601	Rabeprazole sodium cas:117976-90-6	Rabeprazole sodium (LY307640 sodium)is a second-generation proton pump inhibitor(PPI)that irreversibly inactivates gastric H+/K+-ATPase.Rabeprazole sodium induces apoptosis.Rabeprazole sodium acts as an uridine nucleoside ribohydrolase(UNH)inhibitor with an IC50 of 0.3 μM.Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux.	price>
R-R-2301	Ifidancitinib CAS No.1236667-40-5	Ifidancitinib (ATI-50002)/CAS No.1236667-40-5 is a potent and selective inhibitor of JAK kinases 1/3. Ifidancitinib can be used in studies of allergies, asthma and autoimmune diseases.	price>
R-C-602	CGK733 cas:905973-89-9	CGK733,a thiourea-containing compound,was originally identified as a specific inhibitor of ATR and ATM kinases (IC50=~200 nM).In prematurely senescent breast, lung, and colon cancer cells CGK733 reportedly suppresses ATM-mediated p21 expression required for survival,resulting in cell death.	price>
R-R-2302	Protosappanin A CAS No.102036-28-2	Protosappanin A (PTA)/CAS No.102036-28-2, an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3.	price>
R-C-603	vx809 cas:936727-05-8	VX-80(Lumacaftor,VRT 826809) acts to correct CFTR mutations common in cystic fibrosis by increasing mutant CFTR (F508del-CFTR)maturation,EC50 of 0.1 μM in fisher rat thyroid cells.	price>
R-R-2303	Brepocitinib CAS No.1883299-62-4	Brepocitinib (PF-06700841)/CAS No.1883299-62-4 is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. Brepocitinib also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively.	price>
R-C-604	PR-619 cas:2645-32-1	PR-619 is a cell-permeable,reversible,and broad-spectrum inhibitor of the deubiquitinylating enzymes(DUBs).	price>
R-R-2304	TCS 21311 CAS No.1260181-14-3	TCS 21311 (NIBR3049)/CAS No.1260181-14-3 is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively.	price>
R-C-605	Belinostat cas:414864-00-9	Belinostat(PXD101,NSC726630,PX-105684) is a novel HDAC inhibitor with IC50 of 27 nM in a cell-free assay,with activity demonstrated in cisplatin-resistant tumors.Belinostat(PXD101)induces autophagy.	price>
R-R-2305	JAK2-IN-7 CAS No.2593402-36-7	JAK2-IN-7/CAS No.2593402-36-7 is a selective JAK2 inhibitor with IC50s of 3, 11.7, and 41 nM for JAK2, SET-2, and Ba/F3V617F cells, respectively. JAK2-IN-7 possesses >14-fold selectivity over JAK1, JAK3, FLT3. JAK2-IN-7 stimulates cell cycle arrest in the G0/G1 phase and induces tumor cellapoptosis. Antitumor activities.	price>
R-C-606	SNS-314 cas: 1146618-41-8	SNS-314 is a potent and selective inhibitor of Aurora A,Aurora B and Aurora C with IC50 of 9 nM,31 nM,and 3 nM,respectively.It is less potent to Trk A/B, Flt4,Fms,Axl,c-Raf and DDR2.	price>
R-R-2306	JAK-IN-5 hydrochloride CAS No.2751323-21-2	JAK-IN-5 hydrochloride/CAS No.2751323-21-2 is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283.	price>

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