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Catalog	name	Description	price
R-C-607	QNZ (EVP4593) cas:545380-34-5	QNZ(EVP4593)shows strong inhibitory effects on NF-κB transcriptional activation and TNF-αproduction with IC50s of 11 and 7 nM,respectively.QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel.	price>
R-R-2307	BI-1622 CAS No.2681392-19-6	BI-1622/CAS No.2681392-19-6 is an orally active, potent and highly selective HER2 (ERBB2) inhibitor, with an IC50 of 7 nM. BI-1622 shows greater than 25-fold selectivity over EGFR. BI-1622 shows high antitumor efficacy in vivo in xenograft mouse tumor models with engineered H2170 and PC9 cells and had a favorable agent metabolism and pharmacokinetics profile.	price>
R-C-608	SU11274 cas:658084-23-2	SU11274(PKI-SU11274)is a selective Met(c-Met)inhibitor with IC50 of 10 nM in cell-free assays,no effects on PGDFRβ,EGFR or Tie2.SU11274 induces autophagy,apoptosis and cell cycle arrest.	price>
R-R-2308	JAK2/FLT3-IN-1 TFA CAS No.2928093-29-0	JAK2/FLT3-IN-1 (TFA)/CAS No.2928093-29-0 is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 (TFA) has anti-cancer activity.	price>
R-C-609	p005672HCL cas:1035979-44-2	P5091(P005091)is a selective and potent inhibitor of ubiquitin-specific protease 7(USP7)with EC50 of 4.2 μM and the closely related USP47.	price>
R-R-2309	PF-06263276 CAS No.1421502-62-6	PF-06263276 (PF 6263276)/CAS No.1421502-62-6 is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively.	price>
R-C-610	PLX4720 cas:918505-84-7	PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay,equally potent to c-Raf-1(Y340D and Y341D mutations),10-fold selectivity for B-RafV600E than wild-type B-Raf.	price>
R-R-2310	WHI-P97 CAS No.211555-05-4	WHI-P97/CAS No.211555-05-4 is a potent and selective JAK-3 inhibitor. WHI-P97 is effective in preventing the development allergic asthma in vivo.	price>
R-C-611	LDK378 cas:1032900-25-6	LDK378 is a highly selective,orally bioavailable and ATP-competitive small molecule inhibitor of ALK(Anaplastic Lymphoma Kinase),a receptor tyrosine kinase considered to be an important lung cancer drug target.	price>
R-R-2311	SC99 CAS No.882290-02-0	SC99/CAS No.882290-02-0 is an orally active, selective STAT3 inhibitor targeting JAK2-STAT3 pathway. SC99 docks into the ATP-binding pocket of JAK2. SC99 inhibits phosphorylation of JAK2 and STAT3 with no effects on the other kinases associated with STAT3 signaling. SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities.	price>
R-C-612	PluriSln 1 cas:91396-88-2	stearoyl-CoA desaturase 1(SCD1)inhibitor.Used to selectively eliminate undifferentiated human pluripotent stem cells(hPSCs)from culture;induces ER stress,attenuates protein synthesis and induces apoptosis in hPSCs.Prevents teratoma formation in immunocompromised mice.	price>
R-R-2312	RGB-286638 free base CAS No.784210-88-4	RGB-286638/CAS No.784210-88-4 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM.	price>
R-C-613	BKM-120 cas:944396-07-0	Buparlisib(BKM120;NVP-BKM120)is a pan-class I PI3K inhibitor,with IC50s of 52,166,116 and 262 nM for p110α,p110β,p110δ and p110γ,respectively.	price>
R-R-2313	Ilginatinib hydrochloride CAS No.1239358-85-0	Ilginatinib hydrochloride (NS-018 hydrochloride)/CAS No.1239358-85-0 is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM).	price>
R-C-614	Rostafuroxin(PST2238) cas:156722-18-8	Rostafuroxin(PST 2238),a digitoxigenin derivative,is an orally active and potent Na+,K+-ATPase(ATP1A1)antognist.Rostafuroxin binds specifically to the ATP1A1 extracellular domain and blocks respiratory syncytial virus(RSV)-triggered EGFR Tyr845 phosphorylation.Rostafuroxin has antihypertensive and anti-RSV activity.	price>
R-R-2314	Tyk2-IN-7 CAS No.1609391-90-3	Tyk2-IN-7/CAS No.1609391-90-3 is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 provides robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model.	price>
R-C-615	unc1215 Cas:1415800-43-9	UNC1215 is a potent and selective inhibitor for the methyllysine (Kme) reading domain function of L3MBTL3 with a Kd value of 120 nM and an IC50 of 40 nM. UNC1215 has the potential to treat malignant brain tumor.	price>
R-R-2315	Itacitinib adipate CAS No.1334302-63-4	Itacitinib adipate/CAS No.1334302-63-4 is an orally bioavailable and selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis.	price>
R-C-616	Icotinib cas:610798-31-7	Icotinib(BPI-2009H)is a potent and specific EGFR inhibitor with IC50 of 5 nM, including the EGFR,EGFR(L858R),EGFR(L861Q),EGFR(T790M) and EGFR(T790M,L858R).	price>
R-R-2316	JAK2/FLT3-IN-1 CAS No.2387765-27-5	JAK2/FLT3-IN-1/CAS No.2387765-27-5 is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 has anti-cancer activity.	price>

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