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Catalog	name	Description	price
R-C-617	VU0357121 cas:433967-28-3	VU 0357121 is a positive and highly selective mGlu5R allosteric modulator(PAM) with an EC50 of 33 nM.VU 0357121 is inactive or very weakly antagonizing at other mGlu receptor subtypes.	price>
R-R-2317	Lorpucitinib CAS No.2230282-02-5	Lorpucitinib/CAS No.2230282-02-5 is a Gut-Restricted JAK Inhibitor for the research of Inflammatory Bowel Disease.	price>
R-C-618	XL-147 cas:934526-89-3	Pilaralisib(XL147;SAR245408)is a potent and highly selective class I PI3Ks inhibitor with IC50s of 39 nM,383 nM,23 nM and 36 nM for PI3Kα,PI3Kβ,PI3Kγ, and PI3Kδ.	price>
R-R-2318	Ilunocitinib CAS No.1187594-14-4	Ilunocitinib (compound 27)/CAS No.1187594-14-4 is a JAK inhibitor (extracted from patent WO2009114512A1).	price>
R-C-619	PD173074 cas:219580-11-7	PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays,~1000-fold selective for FGFR1 than PDGFR and c-Src.PD173074 reduces proliferation and promotes apoptosis in gastric cancer cells.	price>
R-R-2319	(E/Z)-Zotiraciclib hydrochloride CAS No.1321626-25-8	(E/Z)-Zotiraciclib ((E/Z)-TG02) hydrochloride/CAS No.1321626-25-8 is a potent CDK2, JAK2, and FLT3 inhibitor.	price>
R-C-620	Vicriviroc Malate cas:541503-81-5	Vicriviroc maleate(SCH-417690 maleate;SCH-D maleate) is a potent,selective,oral bioavailable and CNS penetrated antagonist of CCR5,with a Ki of 2.5 nM,and also inhibits HIV-1 in PBMC cells,with IC90s of 3.3 nM (JrFL),2.8 nM (ADA-M), 1.8 nM (301657),4.9 nM (JV1083) and 10 nM (RU 570).	price>
R-R-2320	JAK1-IN-8 CAS No.1973485-18-5	JAK1-IN-8/CAS No.1973485-18-5, a potent JAK1 inhibitor (IC50<500 nM), compound 28, extracted from patent WO2016119700A1.	price>
R-C-621	Maraviroc(Selzentry, UK-427857) cas:376348-65-1	Maraviroc (UK-427857) is a CCR5 antagonist for MIP-1α,MIP-1βand RANTES with IC50 of 3.3 nM,7.2 nM and 5.2 nM in cell-free assays,respectively.Maraviroc is used in the treatment of HIV infection.	price>
R-R-2321	GSK2646264 CAS No.1398695-47-0	GSK2646264 (Compound 44)/CAS No.1398695-47-0 is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.1. GSK2646264 also inhibits other kinases with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 against LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 is penetrable into the epidermis and dermis of the skin.	price>
R-C-622	AT9283 cas:896466-04-9	AT9283 inhibits aurora kinase A and B and targets other tyrosine and serine/threonine kinases associated with myeloid cell proliferation.	price>
R-R-2322	JAK3-IN-1 CAS No.1805787-93-2	JAK3-IN-1/CAS No.1805787-93-2 is a potent, selective and orally active JAK3 inhibitor with an IC50 of 4.8 nM. JAK3-IN-1 shows over 180-fold more selective for JAK3 than JAK1 (IC50 of 896 nM) and JAK2 (IC50 of 1050 nM).	price>
R-C-623	GSK2838232A cas:1443461-21-9	GSK2838232, a betulin derivative,is an inhibitor of human immune virus (HIV) maturation which is potential for the treatment of chronic HIV infection.	price>
R-R-2323	(E/Z)-Zotiraciclib citrate CAS No.1204918-73-9	(E/Z)-Zotiraciclib citrate/CAS No.1204918-73-9 is a potent CDK2, JAK2, and FLT3 inhibitor.	price>
R-C-624	TAK875 CAS:1000413-72-8	Fasiglifam(TAK-875) is a selective GPR40 agonist with EC50 of 14 nM in human GPR40 expressing CHO cell line,400-fold more potent than oleic acid.	price>
R-R-2324	JAK2 JH2 binder-1 CAS No.2923309-41-3	JAK2 JH2 binder-1 (compound 11)/CAS No.2923309-41-3 is a potent and selective JAK2 JH2 binder, with a Kd of 37.1 nM. JAK2 JH2 binder-1 has the potential for various myeloproliferative neoplasms research.	price>
R-C-625	CP690550 cas:540737-29-9	Tofacitinib citrate(CP-690550 citrate)is a novel inhibitor of JAK with IC50 of 1 nM,20 nM and 112 nM against JAK3,JAK2,and JAK1,respectively.Tofacitinib citrate has anti-infection activity.	price>
R-R-2325	G5-7 CAS No.939681-36-4	G5-7/CAS No.939681-36-4, an orally active and allosteric JAK2 inhibitor, selectively inhibits JAK2 mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 induces cell cycle arrest, apoptosis and possesses antiangiogenic effect. G5-7 has the potential for glioma study.	price>
R-C-626	Rivaroxaban cas:366789-02-8	Rivaroxaban(BAY 59-7939)is a direct inhibitor of Factor Xa with Ki and IC50 of 0.4 nM and 0.7 nM in cell-free assays,respectively. It is selective for human factor Xa,for which it has>10 000-fold greater selectivity than for other biologically relevant serine proteases (IC50 >20μM).	price>
R-R-2326	a7 nAchR-JAK2-STAT3 agonist 1 CAS No.2108714-20-9	α7 nAchR-JAK2-STAT3 agonist 1/CAS No.2108714-20-9 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis.	price>

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