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Catalog	name	Description	price
R-C-627	RI-1 (RAD51 inhibitor) cas:415713-60-9	RI-1 is a small molecule that inhibits the central recombination protein RAD51. RI-1 specifically reduces gene conversion in human cells while stimulating single strand annealing.RI-1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into filaments on DNA.	price>
R-R-2327	(2R,5S)-Ritlecitinib CAS No.1792180-79-0	(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600)/CAS No.1792180-79-0 is a potent and selective JAK3 inhibitor (IC50=144.8 nM) extracted from patent US20150158864A1, example 68.	price>
R-C-628	SRPIN340 cas:218156-96-8	SRPIN340 is a cell-permeable isonicotinamide that acts as an ATP-competitive SRPK1-selective inhibitor (IC50=0.14 and 1.8 μM,respectively,against mSRPK1 and mSRPK2)with much reduced activity against 143 other kinases.	price>
R-R-2328	JAK-IN-14 CAS No.1973485-06-1	JAK-IN-14/CAS No.1973485-06-1 is a potent and selective JAK1 inhibitor, with an IC50 of <5 μM. JAK-IN-14 is >8-fold more selective for JAK1 than JAK2 and JAK3 (Patent WO2016119700A1, compound 16).	price>
R-C-629	Tarafenacin cas:385367-47-5	Tarafenacin is a highly selective M3 muscarinic receptor antagonist.It was the most potent in inhibiting carbachol-induced bladder contractions of the anti-cholinergic agents tested,without affecting atrial contractions over the same range of concentrations.	price>
R-R-2329	SD-1029 CAS No.118372-34-2	SD-1029/CAS No.118372-34-2 is a JAK2/STAT3 inhibitor. SD-1029 inhibits STAT3 nuclear translocation. SD-1029 is an inhibitor of STAT3 activation due to inhibition of JAK2 phosphorylation.	price>
R-C-630	Sancycline cas:808-26-4	Sancycline is a rare semi-synthetic tetracycline prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin.	price>
R-R-2330	SJ988497 CAS No.2595365-41-4	SJ988497/CAS No.2595365-41-4 is a PROTAC JAK2 degrader. SJ988497 potently inhibits CRLF2-rearranged (CRLF2r) cell proliferation and degrades the CRBN neosubstrate GSPT1. SJ988497 consists of a Ruxolitinib (HY-50856) derivative, linker, and CRBN ligand Pomalidomide. SJ988497 can be used in the research of acute lymphoblastic leukemia (ALL).	price>
R-C-631	MK4305 cas1030377-33-3	Suvorexant(MK-4305)is a potent,selective,and orally bioavailable antagonist of OX1R and OX2R currently under clinical investigation as a novel therapy for insomnia.	price>
R-R-2331	Tofacitinib-d3 citrate CAS No.2701680-77-3	Tofacitinib-d3 (citrate)/CAS No.2701680-77-3 is deuterium labeled Tofacitinib (citrate). Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities.	price>
R-C-632	Aprepitant (MK-0869) cas:170729-80-3	Aprepitant is classified as an NK1 antagonist.Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons.It has also been shown to increase the activity of the 5-HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone,which are also used to prevent nausea and vomiting caused by chemotherapy.	price>
R-R-2332	Ilginatinib maleate CAS No.1354799-87-3	Ilginatinib maleate (NS-018 maleate)/CAS No.1354799-87-3 is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM).	price>
R-C-633	sp-420 cas:1221411-72-8	SP-420 is an orally active small molecule that selectively binds iron and removes it from the body.In animal studies,SP-420 has shown excellent tissue penetration, highly efficient iron binding and a promising safety profile.	price>
R-R-2333	Oclacitinib CAS No.1208319-26-9	Oclacitinib/CAS No.1208319-26-9 is a novel JAK inhibitor. Oclacitinib is most potent at inhibiting JAK1 (IC50=10 nM).	price>
R-C-634	CP868596 cas:670220-88-9	Crenolanib(CP-868596,ARO 002)is a potent and selective inhibitor of PDGFRα/βwith Kd of 2.1 nM/3.2 nM in CHO cells,also potently inhibits FLT3,sensitive to D842V mutation not V561D mutation,>100-fold more selective for PDGFR than c-Kit,VEGFR-2,TIE-2,FGFR-2,EGFR,erbB2,and Src.Crenolanib helps to induce mitophagy.	price>
R-R-2334	Pumecitinib CAS No.2401057-12-1	Pumecitinib/CAS No.2401057-12-1 is a Janus kinase (JAK) inhibitor with anti-inflammatory activity.	price>
R-C-635	ZCL278 cas:587841-73-4	ZCL-278 is a selective inhibitor of Cdc42.Targets the binding site of the Cdc42 guanine nucleotide exchange factor,intersectin(ITSN).Inhibits Cdc42-mediated cellular effects,including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons.Also suppresses cell motility and migration in PC3 cells,without cytotoxic effects.	price>
R-R-2335	Povorcitinib phosphate CAS No.1637677-33-8	Povorcitinib (INCB54707) phosphate/CAS No.1637677-33-8 is a potent and selective JAK1 inhibitor that effectively reduces abscesses and inflammatory nodules. Povorcitinib phosphate can be used to study cutaneous lupus erythematosus (CLE) and lichen planus (LP) (information extracted from patent WO2021076124A1).	price>
R-C-636	NSC 405020 cas:7497-07-6	NSC 405020 is a novel small molecule inhibitor of MT1-MMP that specifically targets PEX domain rather than the catalytic domain of MT1-MMP with IC50 >100 μM and does not inhibit the catalytic activity of MT1-MMP or MMP-2.	price>
R-R-2336	JAK-IN-3 CAS No.1400876-94-9	JAK-IN-3 (compound 22)/CAS No.1400876-94-9 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.	price>

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