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Catalog	name	Description	price
R-R-2357	STAT6-IN-3 CAS No.371919-80-1	STAT6-IN-3 (Compound 18a)/CAS No.371919-80-1 is a STAT6 inhibitor (IC50= 44 nM). STAT6-IN-3 targets the Src Homology 2 (SH2) domain of STAT6. STAT6-IN-3 can be used for research of inflammation such as asthma.	price>
R-C-658	Amuvatinib (MP-470) CAS :850879-09-3	Amuvatinib(MP470)is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit,PDGFRα,Flt3,c-Met and c-Ret.Amuvatinib(MP470)is also a DNA repair suppressor through suppression of DNA repair protein RAD51,thereby disrupting DNA damage repair. Antineoplastic activity.	price>
R-R-2358	AS1517499 CAS No.919486-40-1	AS1517499/CAS No.919486-40-1 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC50 of 21 nM.	price>
R-C-659	XL019 CAS:945755-56-6	XL019 is a potent,orally active,and selective JAK2 inhibitor,with IC50s of 2.2,134.3,and 214.2 nM for JAK2,JAK1 and JAK3,respectively.XL019 shows 50-fold or greater selectivity for JAK2,versus a panel of over 100 serine/threonine and tyrosine kinases,including other members of the JAK family.XL019 potently inhibits STAT3 and STAT5 phosphorylation in cells harboring either JAK2V617F or wild-type JAK2.	price>
R-R-2359	Cryptotanshinone CAS No.35825-57-1	Cryptotanshinone/CAS No.35825-57-1 is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.	price>
R-C-660	RKI1447 cas:1342278-01-6	RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.	price>
R-R-2360	STAT5-IN-1 CAS No.285986-31-4	STAT5-IN-1/CAS No.285986-31-4 is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform.	price>
R-C-661	SB1317 cas:937270-47-8	SB1317 is a potent inhibitor of CDK2,JAK2,and FLT3 for the treatment of cancer, with IC50 of 13,73,and 56 nM for CDK2,JAK2 and FLT3,respectively.	price>
R-R-2361	AC-4-130 CAS No.1834571-82-2	AC-4-130/CAS No.1834571-82-2 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML).	price>
R-C-662	TAK632 cas: 1228591-30-7	TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50,2.4 nM;BRAF(wt),8.3 nM; CRAF,1.4 nM; pMEK (A375) IC50,12 nM;pMEK (HMVII), 49 nM;V/B ratio.	price>
R-R-2362	SD-36 CAS No.2429877-44-9	SD-36/CAS No.2429877-44-9 is a potent and efficacious STAT3 PROTAC degrader (Kd=~50 nM), and demonstrates high selectivity over other STAT members. SD-36 also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 (IC50=10 nM). SD-36 exerts robust anti-tumor activity, and achieves complete and long-lasting tumor regression in mouse tumor models. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of Cereblon ligand Lenalidomide for E3 ubiquitin ligase. SD-36 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-663	VALDECOXIB cas:181695-72-7	Valdecoxib is a sulfonamide derivative and non-steroidal anti-inflammatory drug (NSAID)with anti-inflammatory,analgesic,and antipyretic activities.Valdecoxib selectively binds to and inhibits cyclooxygenase (COX)-2,thereby preventing the conversion of arachidonic acid into prostaglandins,which are involved in the regulation of pain,inflammation,and fever.This NSAID does not inhibit COX-1 at therapeutic concentrations and therefore does not interfere with blood coagulation.	price>
R-R-2363	2-NP CAS No.65182-56-1	2-NP/CAS No.65182-56-1 is a selective enhancer of STAT1 transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells.	price>
R-C-664	Parecoxib 198470-84-7	Parecoxib(SC 69124)is a highly selective and orally active COX-2 inhibitor,the prodrug of Valdecoxib(HY-15762).Parecoxib Sodium is a nonsteroidal anti-inflammatory agent(NSAID)and inhibits prostaglandin(PG)synthesis.Parecoxib can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.	price>
R-R-2364	AS2863619 CAS No.2241300-51-4	AS2863619/CAS No.2241300-51-4 enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 inhibition of CDK8/19, which consequently activates the Foxp3 gene.	price>
R-C-665	GSK343 cas:1346704-33-3	GSK343 is a potent histone H3-lysine 27(H3K27)methyltransferase EZH2 inhibitor (IC= 4 nM).Diplays 1000-fold selectivity for other HMTs except EZH1(60-fold selectivity).GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC of <200nM (measured by immunofluorescence).	price>
R-R-2365	Corylin CAS No.53947-92-5	Corylin/CAS No.53947-92-5 is an orally active flavonoid anti-inflammatory and osteogenic agent that inhibits IL-6-induced STAT3 promoter activity and STAT3 phosphorylation. Corylin also has anticancer, antiatherosclerotic, and ameliorating activity in hyperlipidemia and insulin resistance, inducing adipocyte browning and lipolysis through SIRT1 or β3-AR-dependent pathways.	price>
R-C-666	PF 4708671 CAS： 1255517-76-0	PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase(S6K1 isoform)with Ki/IC50 of 20 nM/160 nM in cell-free assays,400-fold greater selectivity for S6K1 than S6K2,and 4-and>20-fold selectivity for S6K1 than MSK1 and RSK1/2,respectively.PF-4708671 induces autophagy.First S6K1-specific inhibitor to be reported.	price>
R-R-2366	SI-109 CAS No.2429877-30-3	SI-109/CAS No.2429877-30-3 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36.	price>
R-C-667	Rilpivirine cas:500287-72-9	Rilpivirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI)with higher potency,longer half-life and reduced side-effect profile compared with older NNRTIs,such as efavirenz.	price>

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