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Catalog	name	Description	price
R-R-2367	SC-43 CAS No.1400989-25-4	SC-43/CAS No.1400989-25-4, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects.	price>
R-C-668	XL413 (BMS-863233) cas: 1169562-71-3	BMS-863233,also known as XL-413,is an orally bioavailable cell division cycle 7 homolog(CDC7)kinase inhibitor with potential antineoplastic activity.	price>
R-R-2368	Colivelin CAS No.867021-83-8	Colivelin/CAS No.867021-83-8 is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro. Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease.	price>
R-C-669	BAY57-1293 cas:348086-71-5	Pritelivir(AIC316),an inhibitor of the viral helicase-primase complex,exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection.Pritelivir is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2)with the IC50 of 0.02 μM against HSV1-2.	price>
R-R-2369	Fraxinellone CAS No.28808-62-0	Fraxinellone/CAS No.28808-62-0 is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1.	price>
R-C-670	E7080(Lenvatinib) cas:417716-92-8	Lenvatinib(E7080)is an oral,multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3,FGFR1-4,PDGFR,KIT,and RET,shows potent antitumor activities.	price>
R-R-2370	AS1810722 CAS No.909561-15-5	AS1810722/CAS No.909561-15-5 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research.	price>
R-C-671	STA9090(Ganetespib) cas:888216-25-9	Ganetespib is a heat shock protein 90(HSP90)inhibitor which exhibits potent cytotoxicity in a wide variety of hematological and solid tumor cell lines.	price>
R-R-2371	Casticin CAS No.479-91-4	Casticin/CAS No.479-91-4 is a methyoxylated flavonol isolated from Vitex rotundifolia, with antimitotic and anti-inflammatory effect. Casticin inhibits the activation of STAT3.	price>
R-C-672	UNC1999 cas: 1431612-23-5	UNC1999 is a potent,orally bioavailable and selective inhibitor of EZH2 and EZH1 with IC50 of 2 nM and 45 nM in cell-free assays,respectively,showin>1000-fold selectivity over a broad range of epigenetic and non-epigenetic targets.UNC1999 is a potent autophagy inducer. UNC1999 specifically suppresses H3K27me3/2 and induces a range of anti-leukemia effects including anti-proliferation,differentiation,and apoptosis.	price>
R-R-2372	HJC0152 CAS No.1420290-99-8	HJC0152/CAS No.1420290-99-8 is a signal transducers and activators of transcription 3 (STAT3) inhibitor.	price>
R-C-673	OSU-03012 cas:742112-33-0	OSU-03012 is a novel celecoxib derivative,without cyclooxygenase-2 inhibitory activity,capable of inducing apoptosis in various cancer cells types.	price>
R-R-2373	L002 CAS No.321695-57-2	L002/CAS No.321695-57-2 is a potent, cell permeable, reversible and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 μM. L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation. L002 has the potential for hypertension‐induced cardiac hypertrophy and fibrogenesis treatment.	price>
R-C-674	P529 cas:914913-88-5	Palomid 529 is a dual TORC1/2 inhibitor of the PI3K/Akt/mTOR pathway having broad activity in angiogenesis and cellular proliferation.	price>
R-R-2374	Stafia-1 CAS No.2582757-90-0	Stafia-1/CAS No.2582757-90-0 is a potent STAT5a inhibitor (K i=10.9 μM, IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.	price>
R-C-675	SB1518(Pacritinib) cas:937272-79-2	Pacritinib,also known as SB1518,is an orally bioavailable inhibitor of Janus kinase 2(JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity.Pacritinib competes with JAK2 for ATP binding,which may result in inhibition of JAK2 activation,inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis.	price>
R-R-2375	Mogrol CAS No.88930-15-8	Mogrol/CAS No.88930-15-8 is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.	price>
R-C-676	AVL-292 cas:1202757-89-8	Spebrutinib(CC-292,AVL-292) is a covalent,orally active, and highly selective BTK inhibitor with IC50 of <0.5 nM,displaying at least 1400-fold selectivity over the other kinases assayed.	price>
R-R-2376	YM-341619 CAS No.643082-52-4	YM-341619 (AS1617612)/CAS No.643082-52-4 is a potent and orally active STAT6 inhibitor with an IC50 of 0.70 nM. YM-341619 inhibits Th2 differentiation in mouse spleen T cells induced by IL-4 (IC50=0.28 nM) without affecting Th1 cell differentiation. YM-341619 is a promising compound for the the research of allergic diseases, such as allergic asthma.	price>
R-C-677	Silica coated NaYF4:Yb,Er	Green Upconversion Luminescence(usually obtained at 980/525 and 544 nm excitation/emission wavelengths) is used for temperature measurement in turn. Then,the nanocomposites were applied to the dual-mode in vitro imaging of HepG-2 cells with temperature and O2.A novel multifunctional nano composite mesoporous silica coating NaYF4:Yb,Er@NaYF4 Upconversion ruthenium(II)complex nanoparticles have Green Upconversion Luminescence and red downconversion luminescence,which can be used for temperature detection,oxygen sensing and dual-mode cell imaging.	price>

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