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Catalog	name	Description	price
R-R-2377	Picroside I CAS No.27409-30-9	Picroside I/CAS No.27409-30-9 is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II. Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ.	price>
R-C-678	Silica coated NaYF4:Yb,Tm	Carbon dots are embedded in the SiO2 coating on the surface of nano NaYF4:Yb,TM particles to form a relatively stable nanocomposite.The nanocomposites show interesting dual-mode luminescence properties,i.e.blue-green light under 365 nm ultraviolet lamp and blue violet light under 980 nm laser.	price>
R-R-2378	Stafib-1 CAS No.1688703-26-5	Stafib-1/CAS No.1688703-26-5 is the first selective inhibitor of the STAT5b SH2 domain, with a Ki of 44 nM and an IC50 of 154 nM.	price>
R-C-679	Silica coated NaYF4:Yb,Er@NaYF4(980 excitation, green light)	Nano composite NaYF4:Yb,Er@NaYF4@mSiO2-Ru There are two working modes:its red down conversion luminescence (at 455/606nm excitation/emission peak)is quenched by oxygen(O2),which is used to sense and image O2.A novel multifunctional nano composite mesoporous silica coating NaYF4:Yb,Er@NaYF4 Upconversion ruthenium (II) complex nanoparticles have Green Upconversion Luminescence and red downconversion luminescence,which can be used for temperature detection,oxygen sensing and dual-mode cell imaging.	price>
R-R-2379	Ochromycinone CAS No.111540-00-2	Ochromycinone ((Rac)-STA-21)/CAS No.111540-00-2 is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity.	price>
R-C-680	Silica coated NaYF4:Yb,Tm@NaYF4(980 excitation, blue light)	Multi shell NaYF4:Yb,TM,Nd@NaYF4:Yb,Nd@SiO2@ZnO Active core/active shell upconversion nanoparticles(ucnps)were firstly combined with ZnO semiconductor to prepare nanospheres.	price>
R-R-2380	NSC-370284 CAS No.116409-29-1	NSC-370284/CAS No.116409-29-1 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5.	price>
R-C-681	Silica coated NaYF4,Yb,Er@NaYF4,Yb,Nd(808 excited, green)	Ucnps have attracted more and more attention as drug carriers,because it provides a unique opportunity to integrate treatment and diagnosis into a platform (therapeutics).Hexagonal NaYF4:Yb/erucnps were synthesized by microwave-assisted method,coated with porous silica and functionalized with amine.	price>
R-R-2381	STX-0119 CAS No.851095-32-4	STX-0119/CAS No.851095-32-4 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.	price>
R-C-682	Silica coated NaYF4,Yb,Tm@NaYF4,Yb,Nd(808 excited, blue light)		price>
R-R-2382	Angoline CAS No.21080-31-9	Angoline/CAS No.21080-31-9 is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.	price>
R-C-683	NH2-silica NaYF4:Yb,Er (980 excitation, green light)	Dual-functional nanosensors based on small molecule regulation can be widely used due to their simplicity,high sensitivity and selectivity.glutathione (GSH) calibrated dual-functional system for GSH and cadmium ions(Cd2+)detection based on fluorescence resonance energy transfer(FRET)between NH2-NaYF4:Yb,Er/NaYF4@SiO2 upconversion nanoparticles(UCNPs)and gold nanoparticles (AuNPs)is designed.	price>
R-R-2383	NT219 CAS No.1198078-60-2	NT219/CAS No.1198078-60-2 is a potent and dual inhibitor of insulin receptor substrates 1/2 (IRS1/2) and STAT3. IRS1/2 and STAT3 are major signaling junctions regulated by various oncogenes. NT219 affects IRS1/2 degradation and inhibits STAT3 phosphorylation. NT219 has the potential for the research of cancer diseases.	price>
R-C-684	NH2-silica NaYF4:Yb,Tm (980 excitation, blue light)	NaYF4:20% Yb,0.5% TM upconversion luminescent nanoparticles(ucnps) were synthesized by solvothermal method,The morphology and luminescent properties of the water-soluble nanoparticles were characterized by scanning electron microscopy,X-ray diffraction analysis and luminescent spectroscopy.	price>
R-R-2384	STAT5-IN-2 CAS No.2111834-61-6	STAT5-IN-2/CAS No.2111834-61-6 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect.	price>
R-C-685	NH2-silica NaYF4:Yb,Er@NaYF4(980 excitation, green light)	NH2-silica NaYF4:Yb,Er@NaYF4 The excitation wavelength of the product is 980nm, the emission wavelength is 540/650nm±15nm,the product emits green light, dissolves in water,and the particle size under the electron microscope is 50 ± 15nm.	price>
R-R-2385	UC-514321 CAS No.299420-83-0	UC-514321/CAS No.299420-83-0, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.	price>
R-C-686	NH2-silica NaYF4:Yb,Tm@NaYF4(980 excitation, blue light)	NH2-silica NaYF4:Yb,Tm@NaYF4 The surface ligand of(NH2) is NH2,the excitation wavelength is 980nm,the emission wavelength is 365/450/470nm±15nm,the light is blue,and the solvent is water.	price>
R-R-2386	AS2863619 free base CAS No.2241300-50-3	AS2863619 free base/CAS No.2241300-50-3 enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene.	price>
R-C-687	NH2-silica NaYF4,Yb,Er@NaYF4,Yb,Nd(808 excited, green)	NH2-silica NaYF4,Yb,Er@NaYF4 Yb, nd upconversion fluorescent nanomaterials with particle size of 50±15 and solvent of water under electron microscope.	price>

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