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R-R-2387 LLL12 CAS No.1260247-42-4 LLL12/CAS No.1260247-42-4 is a small molecule inhibitor of STAT3 that inhibits STAT3 phosphorylation. LLL12 enhanced the inhibitory effect of Cisplatin (HY-17394) and Paclitaxel (HY-B0015) on ovarian cancer cell formation, migration, and growth. price>
R-C-688 NH2-silica NaYF4,Yb,Tm@NaYF4,Yb,Nd (808 excitation, green light) NH2-silica NaYF4,Yb,Tm@NaYF4 Yb, nd are amino silica products.They emit blue fluorescence at the emission wavelength of 808nm and the excitation wavelength of 365/450/470nm±15nm.The solvent is water. price>
R-R-2388 inS3-54A18 CAS No.328998-53-4 inS3-54A18/CAS No.328998-53-4 is a potent STAT3 inhibitor, with anti-cancer properties. price>
R-C-689 Mesoporous silica coating NaYF4:Yb,Er (980 excited, green) Mesoporous silica coating NaYF4:Yb,ER are nanocomposites,which are composed of upconversion luminescent nanoparticles coated with mesoporous silica and oxygen sensitive luminescent ruthenium complexes.The emission wavelength is 980 nm and the surface ligand is Si oh.The emission of fluorescence is green. price>
R-R-2389 Golotimod hydrochloride CAS No.1029401-59-9 Golotimod hydrochloride (SCV 07 hydrochloride)/CAS No.1029401-59-9, an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod hydrochloride (SCV 07 hydrochloride) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod hydrochloride (SCV 07 hydrochloride) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2). price>
R-C-690 Mesoporous silica coating NaYF4:Yb,Tm (980 excited, blue light) Mesoporous silica coating NaYF4:Yb,Er@NaYF4 upconversion nanoparticles loaded with ruthenium(II)complex nanoparticles:Fluorometric sensing and cellular imaging of temperature by upconversion and of oxygen by downconversion. price>
R-R-2390 OSM-SMI-10B OSM-SMI-10B a derivative of OSM-SMI-10. OSM-SMI-10B significantly reduces OSM-induced STAT3 phosphorylation in cancer cells upon co-incubation with OSM (Oncostatin M). price>
R-C-691 Mesoporous silica coating NaYF4:Yb,Er@NaYF4(980 excitation, green light) Nano composite NaYF4:Yb,@NaYF4@mSiO2-Ru There are two working modes:its red down conversion luminescence (at 455/606nm excitation/emission peak)is quenched by oxygen(O2),which is used to sense and image O2.Green Upconversion Luminescence(usually obtained at 980/525 and 544 nm excitation/emission wavelengths)is used for temperature measurement in turn.Then,the nanocomposites were applied to the dual-mode in vitro imaging of HepG-2 cells with temperature and O2. price>
R-R-2391 PM-43I CAS No.1637532-77-4 PM-43I/CAS No.1637532-77-4 is a potent STAT6 inhibitor and can reduce STAT6 phosphorylation level. PM-43I can be used in allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease and cancer research. price>
R-C-692 Mesoporous silica coating NaYF4:Yb,Tm@NaYF4 (980 excited, blue light) Mesoporous silica coated core-shell upconversion nanoparticles(980 excitation, blue light)with hydroxyl groups as surface ligands,and the particle size is 50±15nm under electron microscope. price>
R-R-2392 Garcinone C CAS No.76996-27-5 Garcinone C/CAS No.76996-27-5, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and CDK7. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner. price>
R-C-693 Mesoporous silica coating NaYF4,Yb,Er@NaYF4,Yb,Nd (808 excited, green) Mesoporous silica coated core-shell upconversion nanoparticles(980 excitation, blue light) have an emission wavelength of 540/650 nm±15 nm,a surface ligand of hydroxyl group,and a particle size of 50 ± 15 under electron microscope. The solvent is water. price>
R-R-2393 AK-2292 AK-2292 is a potent and selective STAT5 PROTAC degrader, with a DC50 of 0.10 μM. AK-2292 induces degradation of STAT5A/B proteins in vitro and in vivo. AK-2292 can induce tumor regression in acute myeloid leukemia and chronic myeloid leukemia xenograft mouse models. AK-2292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. price>
R-C-694 Mesoporous silica coating NaYF4,Yb,Tm@NaYF4,Yb,Nd(808 excited, blue light) Mesoporous silica coated core-shell structure upconversion nanoparticles(980 excitation,blue light),emission wavelength is 365/450/470 nm ± 15 nm,surface ligand is hydroxyl,particle size under electron microscope is 50 ± 15.Solvent is water. price>
R-R-2394 IST5-002 CAS No.13484-66-7 IST5-002/CAS No.13484-66-7, a potent Stat5a/b inhibitor, selectively inhibits transcriptional activity of Stat5a/b (IC50s: 1.5 μM for Stat5a, 3.5 μM for Stat5b). IST5-002 inducs cell apoptotic and death of prostate cancer cells and chronic myeloid leukemia (CML) cells. IST5-002 can be used in the research of prostate cancer and chronic myeloid leukemia (CML). price>
R-C-695 Amine Functional Mesoporous silica coating NaYF4:Yb,Er(980 excitation, green light) Amidated mesoporous silica coated up conversion nanoparticles (980 excitation, green light),540/650nm±15 nm,surface ligand is NH2,particle size under electron microscope is 50±10.The solvent is water. price>
R-R-2395 Cirsilineol CAS No.41365-32-6 Cirsilineol/CAS No.41365-32-6, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4+ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice. price>
R-C-696 Amine Functional Mesoporous silica coating NaYF4:Yb,Tm(980 excitation, blue light) Amino mesoporous silica coated up conversion nanoparticles (980 excitation, blue light) have an emission wavelength of 365/450/470 nm±2 nm,a surface ligand of NH2,and a particle size of 50±10 under electron microscope.The solvent is water. price>
R-R-2396 HODHBt CAS No.28230-32-2 HODHBt (HOOBt)/CAS No.28230-32-2 inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer. price>
R-C-697 Amine Functional Mesoporous silica coating NaYF4:Yb,Er@NaYF4(980 excitation, green light) Amino mesoporous silica coated core-shell upconversion nanoparticles (980 excitation, green light) have an emission wavelength of 540/650 nm±2 nm,a surface ligand of NH2,and a particle size of 50±10nm under electron microscope. The solvent is water. price>