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Catalog	name	Description	price
R-R-2417	STAT3-IN-17 CAS No.1245814-52-1	STAT3-IN-17/CAS No.1245814-52-1 is a moderate STAT3 inhibitor (IC50=0.7 μM; HEK-Blue IL-6), with antiproliferative activity in HeLa cells. STAT3-IN-17 has good pharmacokinetic characteristics. STAT3-IN-17 also inhibits pyruvate-ferredoxin oxidoreductase (PFOR), and inhibits Helicobacter pylori.	price>
R-C-718	AWD 131-138 CAS:188116-07-6	AWD 131-138(Imepitoin,ELB-138) is a centrally acting anti-epileptic which crosses the blood brain barrier and is used for the treatment of canine idiopathic epilepsy.AWD 131-138(Imepitoin)is an antiepileptic and antianxietic drug,AWD 131-138 can stimulate different recombinant isoforms of the rat GABA(A) receptor through the benzodiazepine binding site.	price>
R-R-2418	MNK8 CAS No.2055078-49-2	MNK8/CAS No.2055078-49-2 is a potent STAT3 (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells.	price>
R-C-719	BX795 CAS:702675-74-9	BX795 is a potent and selective inhibitor of PDK1,with an IC50 of 6 nM.BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKɛ,with an IC50 of 6 and 41 nM,respectively.BX795 blocks phosphorylation of S6K1,Akt, PKCδ,and GSK3β,and has lower selectivity over PKA,PKC,c-Kit,GSK3β etc.BX795 modulates autophagy.	price>
R-R-2419	LY5 CAS No.1436382-03-4	LY5/CAS No.1436382-03-4 is a STAT3 inhibitor with an IC50 value of 0.5 μM. LY5 induces apoptosis and inhibits STAT3 phosphorylation. LY5 shows antitumor activity in vivo, it can be used for the research of cancer.	price>
R-C-720	CID-2011756 CAS:638156-11-3	CID 2011756 is an ATP competitive PKD inhibitor,with an IC50 of 3.2 µM for PKD1 in cell free assay,and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50,0.6 and 0.7 µM,respectively).CID 2011756 also has antitumor activity.	price>
R-R-2420	Pimozide-d4 CAS No.1803193-57-8	Pimozide-d4/CAS No.1803193-57-8 is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.	price>
R-C-721	Tenovin-3 CAS:1011301-27-1	Tenovin-3 is a small molecule activator of p53 transcriptional activity. It increases p53 activity in MCF-7 cells when used at a concentration of 10 µM.It also increases the level of K40-acetylated alpha-tubulin in H1299 cells and inhibits SIRT2 protein deacetylase activity.	price>
R-R-2421	Pimozide-d4-1	Pimozide-d4-1 is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.	price>
R-C-722	Ampalex (CX-516) CAS:154235-83-3	CX516(BDP 12)is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer is disease,schizophrenia and mild cognitive impairment(MCI).	price>
R-R-2422	Nifuroxazide-d4 CAS No.1188487-83-3	Nifuroxazide-d4/CAS No.1188487-83-3 is the deuterium labeled Nifuroxazide. Nifuroxazide is an effective inhibitor of STAT3, also exerts potent anti-tumor and anti-metastasis activity.	price>
R-C-723	AR-A014418 CAS:487021-52-3	AR-A 014418 is a selective glycogen synthase kinase 3(GSK-3)inhibitor(IC50=104 nM).Exhibits specificity for GSK-3 over cdk2 and cdk5(IC50 values are>100 μM) and over 26 other kinases.Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.	price>
R-R-2423	Galiellalactone CAS No.133613-71-5	Galiellalactone/CAS No.133613-71-5 is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC50 of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer.	price>
R-C-724	JNJ-26854165 (Serdemetan) CAS:881202-45-5	Serdemetan(JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells,inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53.	price>
R-R-2424	HJC0416 hydrochloride CAS No.2415263-08-8	HJC0416 hydrochloride/CAS No.2415263-08-8 is a potent and orally active STAT3 inhibitor with an enhanced anticancer profile than Stattic (HY-13818). HJC0416 hydrochloride is a promising anti-cancer agent for breast cancer study.	price>
R-C-725	tcs1102 CAS No. : 916141-36-1	TCS 1102 is a potent,dual orexin receptor antagonist(Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively).	price>
R-R-2425	Revumenib CAS No.2169919-21-3	Revumenib (SNDX-5613)/CAS No.2169919-21-3 is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. Revumenib can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).	price>
R-C-726	Huperzine A CAS：102518-79-6	(-)-Huperzine A is a potent,highly specific and reversible inhibitor of acetylcholinesterase (AChE)with Ki of 7 nM,exhibiting 200-fold more selectivity for G4 AChE over G1 AChE.Also acts as an NMDA receptor antagonist.	price>
R-R-2426	Pelabresib CAS No.1380087-89-7	Pelabresib (CPI-0610)/CAS No.1380087-89-7 is a potent, selective, orally active and cell-active BET inhibitor. Pelabresib inhibits BRD4-BD1 with an IC50 of 39 nM, and with an EC50 value of 0.18 μM for MYC.	price>
R-C-727	AdipoRon (SC-396658) CAS No. 924416-43-3	AdipoRon(SC-396658)is a novel, and orally bioavailable adiponectin receptor agonist with KD of 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively.	price>

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