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Catalog	name	Description	price
R-R-2437	I-BET151 CAS No.1300031-49-5	I-BET151 (GSK1210151A)/CAS No.1300031-49-5 is a BET bromodomain inhibitor which inhibits BRD4, BRD2, and BRD3 with pIC50 of 6.1, 6.3, and 6.6, respectively.	price>
R-C-738	erastin CAS No. 571203-78-6	Erastin is a cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality in cells with H-Ras mutations.	price>
R-R-2438	ARV-771 CAS No.1949837-12-0	ARV-771/CAS No.1949837-12-0 is a powerful BET degrader based on PROTAC technology with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM and 7.6 nM for BRD2 (1) , BRD2 (2), BRD3 (1), BRD3 (2), BRD4 (1) and BRD4 (2), respectively.	price>
R-C-739	SCH-772984 CAS No. 942183-80-4	SCH772984 is a novel,specific inhibitor of ERK1/2 with IC50 values of 4 nM and 1 nM in cell-free assay,respectively,And show robust efficacy in RAS-or BRAF-mutant cancer cells.	price>
R-R-2439	dBET1 CAS No.1799711-21-9	dBET1/CAS No.1799711-21-9 is a PROTAC connected by ligands for Cereblon and BRD4 with an EC50 of 430 nM. dBET1 is a PROTAC that composes of (+)-JQ1 (HY-13030) linked to NSC 527179 (HY-14658) with a linker.	price>
R-C-740	PF-3274167 cas:900510-03-4	Cligosiban (PF-3274167),a high oral bioavailability and good brain-penetrant non-peptide oxytocin receptor antagonist,shows a high-affinity(Ki=9.5 nM)and an excellent selectivity versus the vasopressin receptors with almost no affinity for the V1b and V1a subtypes.Cligosiban inhibits ejaculatory physiology in rodents.	price>
R-R-2440	dCBP-1 CAS No.2484739-25-3	dCBP-1/CAS No.2484739-25-3 is a potent and selective heterobifunctional degrader of p300/CBP based on Cereblon ligand. dCBP-1 is exceptionally potent at killing multiple myeloma cells and ablates oncogenic enhancer activity driving MYC expression.	price>
R-C-741	ISRIB CAS : 1597403-47-8	ISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM.	price>
R-R-2441	FHD-286 CAS No.2671128-05-3	FHD-286/CAS No.2671128-05-3 is a selective, oral inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor. FHD-286 has the potential for the research of BAF (BRG1/BRM-associated factor)-related disorders such as acute myeloid leukemia.	price>
R-C-742	USP7-USP47 cas:1247825-37-1	USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor,with EC50s of 0.42 μM and 1.0 μM,respectively.	price>
R-R-2442	NSC 228155 CAS No.113104-25-9	NSC 228155/CAS No.113104-25-9 is an activator of EGFR, binds to the extracellular region of EGFR and enhances tyrosine phosphorylation of EGFR. NSC 228155 is also a potent inhibitor of KIX-KID interaction, inhibits the kinase-inducible domain (KID) of CREB and the KID-interacting domain (KIX) of CBP, with an IC50 of 0.36 μM.	price>
R-C-743	GSK1838705A CAS:1116235-97-2	GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L,respectively.	price>
R-R-2443	MG 149 CAS No.1243583-85-8	MG149 (Tip60 HAT inhibitor)/CAS No.1243583-85-8 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM).	price>
R-C-744	AZD628 CAS No. : 942436-93-3	AZD-6280 is a selective GABAA(α2/3) receptor modulator,used for treatment of generalized anxiety disorder.	price>
R-R-2444	Ziftomenib CAS No.2134675-36-6	Ziftomenib (KO-539)/CAS No.2134675-36-6 is an orally active menin-MLL interaction inhibitor with antitumor activities (WO2017161028A1, compound 151).	price>
R-C-745	NVP-QAV-572 CAS:957209-68-6	NVP-QAV-572 is a potent PI3K kianse inhibitor with IC50 of 10 nM.	price>
R-R-2445	GNE-781 CAS No.1936422-33-1	GNE-781/CAS No.1936422-33-1 is an orally active, highly potent and selective CBP inhibitor with an IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50s of 6.2 nM and 5100 nM, respectively. GNE-781 displays antitumor activity in an MOLM-16 AML xenograft model.	price>
R-C-746	LEE011 cas:1211441-98-3	Ribociclib(LEE01)is a highly specific CDK4/6inhibitor with IC50 values of 10 nM and 39 nM,respectively,and is over 1,000-fold less potent against the cyclin B/CDK1 complex.	price>
R-R-2446	GSK778 CAS No.2451862-42-1	GSK778 (iBET-BD1)/CAS No.2451862-42-1 is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 phenocopies the effects of pan-BET inhibitors in cancer models.	price>
R-C-747	APY29 cas:1216665-49-4	APY29,an ATP-competitive inhibitor,is an allosteric modulator of IRE1α which inhibits IRE1α autophosphorylation by binding to the ATP-binding pocket with IC50 of 280 nM.APY29 acts as a ligand that allosterically activates IRE1α adjacent RNase domain.	price>

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