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Catalog	name	Description	price
R-R-2447	NEO2734 CAS No.2081072-29-7	NEO2734 (EP31670)/CAS No.2081072-29-7 is an orally active dual p300/CBP and BET bromodomain selective inhibitor, with IC50 values of <30 nM for both p300/CBP and BET bromodomains. NEO2734 is active in SPOP mutant and wild-type prostate cancer.	price>
R-C-748	PTC-209 cas:315704-66-6	PTC-209 is a novel potent and selective BMI-1 inhibitor,targeting the BMI-1 self-renewal machinery with an IC50 of ~0.5 μM.	price>
R-R-2448	E-7386 CAS No.1799824-08-0	E-7386/CAS No.1799824-08-0 is an orally active CBP/beta-catenin modulator.	price>
R-C-749	TCS PIM-1 1 cas:491871-58-0	TCS PIM-1 1(SC 204330) is a potent,selective and ATP-competitive Pim-1 kianse inhibitor with an IC50 of 50 nM,displays good selectivity over Pim-2 and MEK1/MEK2 (IC50s >20000 nM).	price>
R-R-2449	ZXH-3-26 CAS No.2243076-67-5	ZXH-3-26/CAS No.2243076-67-5 is a PROTAC connected by ligands for Cereblon and BRD4 with a DC50/5h of 5 nM. The DC50/5h refers to half-maximal degradation after 5 hours of treatment of ~ 5 nM.	price>
R-C-750	NVP-BSK805 2HCl CAS No. 1942919-79-0	NVP-BSK805 is a potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor that potently suppressed recombinant human erythropoietin-induced polycythemia and extramedullary erythropoiesis in mice and rats.	price>
R-R-2450	BAY-850 CAS No.2099142-76-2	BAY-850/CAS No.2099142-76-2 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM.	price>
R-C-751	BMS303141 cas: 943962-47-8	BMS303141 is a potent inhibitor of ATP citrate lyase(ACL).BMS303141 inhibits lipid synthesis in HepG2 cells with an IC50 of 8 μM,and lowers plasma triglycerides in a murine hyperlipdemia model.	price>
R-R-2451	GSK046 CAS No.2474876-09-8	GSK046 (iBET-BD2)/CAS No.2474876-09-8 is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively. GSK046 has immunomodulatory activity.	price>
R-C-752	C7280948 cas:587850-67-7	C-7280948 is a selective and potent protein methyltransferase1(PRMT1)inhibitor with an IC50 value of 12.75 μM.	price>
R-R-2452	dTRIM24 CAS No.2170695-14-2	dTRIM24/CAS No.2170695-14-2 is a selective bifunctional degrader of TRIM24 based on PROTAC, consists of ligands for von Hippel-Lindau and TRIM24.	price>
R-C-753	CVT-10216 cas:1005334-57-5	CVT-10216 is a highly selective,reversible aldehyde dehydrogenase-2(ALDH-2)inhibitor with an IC50 of 29 nM.CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM.CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects.	price>
R-R-2453	CPI-637 CAS No.1884712-47-3	CPI-637/CAS No.1884712-47-3 is a selective and potent CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 μM, 0.051 μM and 11.0 μM for CBP, EP300 and BRD4 BD-1, respectively, and an EC50 of 0.3 μM for CBP.	price>
R-C-754	GNF-5 cas:778277-15-9	GNF-5,an analogue of GNF-2 with improved pharmacokinetic properties,is a selective non-ATP competitive inhibitor of Bcr-Abl with an IC50 value of 0.22±0.1 uM (Wild type Abl).	price>
R-R-2454	I-BRD9 CAS No.1714146-59-4	I-BRD9/CAS No.1714146-59-4 is a selective cellular chemical probe of bromodomain-containing protein 9 (BRD9) with pIC50 value of 7.3 μM. I-BRD9 has high selectivity for bromodomain and extra terminal domain (BET) family and highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 can be used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways.	price>
R-C-755	PU-H71 cas:873436-91-0	PU-H71(NSC 750424)is a potent and selective inhibitor of HSP90 with IC50 of 51 nM.	price>
R-R-2455	MI-3454 CAS No.2134169-43-8	MI-3454/CAS No.2134169-43-8 is an orally active, highly potent and selective menin-MLL1 interaction inhibitor with an IC50 of 0.51 nM. MI-3454 inhibits proliferation, induces differentiation and complete remission or regression of leukemia in mouse models of MLL1-rearranged or NPM1-mutated leukemia through downregulation of key genes involved in leukemogenesis.	price>
R-C-756	EPZ5676 cas:1380288-87-8	Pinometostat(EPZ5676)is an S-adenosyl methionine(SAM)competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM in a cell-free assay, demonstrating >37,000-fold selectivity against all other PMTs tested,inhibits H3K79 methylation in tumor.	price>
R-R-2456	IACS-9571 hydrochloride CAS No.2319611-93-1	IACS-9571 (ASIS-P040) hydrochloride/CAS No.2319611-93-1 is a potent and selective inhibitor of TRIM24 and BRPF1, with an IC50 of 8 nM for TRIM24, and Kds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.	price>
R-C-757	KPT185 cas:133315-73-7	KPT185 is a selective CRM1 inhibitor.KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM,and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts.	price>

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