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Catalog	name	Description	price
R-R-2457	VZ185 CAS No.2306193-61-1	VZ185/CAS No.2306193-61-1 is a potent, fast, and selective von Hippel-Lindau based dual degrader probe of BRD9 and BRD7 with DC50s of 4.5 and 1.8 nM, respectively. VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC50s of 3 nM and 40 nM, respectively.	price>
R-C-758	Romidepsin (FK228, Depsipeptide) cas:128517-07-7	Romidepsin(FK 228)is a Histone deacetylase(HDAC)inhibitor with anti-tumor activities.Romidepsin(FK 228)inhibits HDAC1,HDAC2,HDAC4,and HDAC6 with IC50s of 36 nM,47 nM,510 nM and 1.4 μM,respectively.Romidepsin(FK 228)is produced by Chromobacterium violaceum,induces cell G2/M phase arrest and apoptosis.	price>
R-R-2458	(R)-(-)-JQ1 Enantiomer CAS No.1268524-71-5	(R)-(-)-JQ1 Enantiomer/CAS No.1268524-71-5 is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect.	price>
R-C-759	LX1606 cas:1033805-22-9	LX 1606 is an orally bioavailable,small-molecule,tryptophan hydroxylase(TPH) inhibitor with potential antiserotonergic activity.	price>
R-R-2459	GNE-049 CAS No.1936421-41-8	GNE-049/CAS No.1936421-41-8 is a highly potent and selective CBP inhibitor with an IC50 of 1.1 nM in TR-FRET assay. GNE-049 also inhibits BRET and BRD4(1) with IC50s of 12 nM and 4200 nM, respectively.	price>
R-C-760	sgc0946 CAS No. 1561178-17-3	SGC0946 is a highly potent and selective DOT1L methyltransferase inhibitor with IC50 of 0.3 nM;selectively kill mixed lineage leukaemia cells.	price>
R-R-2460	FHT-1015 CAS No.2368903-18-6	FHT-1205/CAS No.2368903-18-6 is a potent SMARCA4/SMARCA2 ATPase (BRG1 and BRM) inhibitor with IC50s of ≤10 nM (WO2020160180A1; compound 67).	price>
R-C-761	SKLB1002 cas:1225451-84-2	SKLB1002 is a new potent VEGFR2 inhibitor,which could significantly inhibit HUVEC proliferation,migration,invasion,and tube formation.	price>
R-R-2461	GSK2801 CAS No.1619994-68-1	GSK2801/CAS No.1619994-68-1 is a potent, selective, orally active and cell active acetyl-lysine competitive BAZ2A and BAZ2B bromodomains inhibitor with Kd values of 136 nM and 257 nM, respectively. GSK2801 shows >50-fold selectivity for BAZ2A/B over BRD4.	price>
R-C-762	HS-173 cas:1276110-06-5	HS-173,a novel phosphatidylinositol 3-kinase(PI3K)inhibitor,has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis.	price>
R-R-2462	BRD4 degrader AT1 CAS No.2098836-45-2	BRD4 degrader AT1/CAS No.2098836-45-2 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4 as a highly selective Brd4 degrader, with a Kd of 44 nM for Brd4BD2 in cells.	price>
R-C-763	DAPT (GSI-IX, LY-374973) cas:208255-80-5	DAPT(GSI-IX,LY-374973)is a novel γ-secretase inhibitor,which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy.	price>
R-R-2463	BAY-299 CAS No.2080306-23-4	BAY-299/CAS No.2080306-23-4 is a very potent, dual inhibitor with IC50s of 67 nM for BRPF2 bromodomains (BD), 8 nM for TAF1 BD2, and 106 nM for TAF1L BD2.	price>
R-C-764	CZC54252 CAS:1191911-27-9	CZC54252 is a highly effective inhibitor of LRRK2.Its IC50 values for wild-type LRRK2 and mutant G2019S LRRK2 are 1.28 and 1.85 nm,respectively.	price>
R-R-2464	FKBP12 PROTAC dTAG-7 CAS No.2064175-32-0	FKBP12 PROTAC dTAG-7 (dTAG-7)/CAS No.2064175-32-0 is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN.	price>
R-R-2465	Trotabresib CAS No.1706738-98-8	CC-90010 (compound 1)/CAS No.1706738-98-8 is a reversible and orally active BET inhibitor. CC-90010 is applied in the study for advanced solid tumors.	price>
R-R-2466	Biotinylated-JQ1 CAS No.1635437-52-3	Biotinylated-JQ1 (Biotin-JQ1)/CAS No.1635437-52-3 is a biotinylated derivative of JQ1 with high affinity for the bromodomain of BRD4. Biotinylated-JQ1 inhibits MM1.S multiple myeloma cells proliferation with the EC50 of 0.4 μM.	price>
R-R-2467	A1874 CAS No.2064292-12-0	A1874/CAS No.2064292-12-0 is a nutlin-based (MDM2 ligand) and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation.	price>
R-R-2468	SGC-SMARCA-BRDVIII CAS No.1997319-84-2	SGC-SMARCA-BRDVIII/CAS No.1997319-84-2 is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts.	price>
R-R-2469	(+)-JQ1 PA CAS No.2115701-93-2	(+)-JQ1 PA/CAS No.2115701-93-2 is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC50 of 10.4 nM. (+)-JQ1 PA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>

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