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R-R-2482 CBP/p300-IN-12 CAS No.2738688-57-6 CBP/p300-IN-12/CAS No.2738688-57-6 is a potent and selective covalent histone acetyltransferases p300 (IC50 of 166 nM) and CBP inhibitor. CBP/p300-IN-12 decreases the levels of H3K27Ac of PC-3 cells (EC50 of 37 nM). CBP/p300-IN-12 forms a covalent adduct with C1450. price>
R-C-783 TCO-PEG5000-Maleimide As a kind of amphiphenyl,trans cyclooctene(TCO)has the advantages of no catalyst and fast reaction rate in physiological conditions.It has been widely used in the research of biology and materials science.Peg can enhance solubility and stability,reduce the surface non-specific binding of charged molecules,and reduce the immunogenicity of polypeptide. price>
R-R-2483 PF-CBP1 hydrochloride CAS No.2070014-93-4 PF-CBP1 hydrochloride/CAS No.2070014-93-4 is a highly selective inhibitor of the CREB binding protein bromodomain (CBP BRD). PF-CBP1 inhibits CREBBP and EP300 bromodomains with IC50 of 125 nM and 363 nM respectively. PF-CBP1 hydrochloride reduces LPS-induced inflammatory cytokines expression (IL-1β, IL-6 and IFN-β) in primary macrophages. PF-CBP1 hydrochloride also downregulates RGS4 expression cortical neurons and can be used for the research of neurological disorders. price>
R-R-2484 BAY1238097 CAS No.1564268-08-1 BAY1238097/CAS No.1564268-08-1 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome (IC50 <100 nM). price>
R-C-785 PBA-PEG1000-cRGD 1-Pyrenebutyric acid(PBA)is a conjugated polymer that has a large π system and a carboxylic group.It is majorly used in surface functionalization.It has a high fluorescence efficiency and stability that make it useful in optoelectronic applications. price>
R-R-2485 (S)-JQ-35 CAS No.1349719-98-7 (S)-JQ-35 (TEN-010)/CAS No.1349719-98-7 is an inhibitor of the Bromodomain and Extra-Terminal (BET) family bromodomain-containing proteins with potential antineoplastic activity. price>
R-C-786 Compound customization (Rhodamine fluorescence) Rhodamine is a laser dye,which is used for biological dyeing.It is a fluorescent dye,catechol.Rhodamine B is mainly used for industrial dyeing,and it is fat soluble.Rhodamine B has strong fluorescence in solution,so it can be used as fluorescent staining agent in laboratory. price>
R-R-2486 ACBI2 CAS No.2913161-19-8 ACBI2/CAS No.2913161-19-8 is a highly potent and orally active VHL PROTAC SMARCA2 degrader (EC50: 7 nM), which selectively degrades SMARCA2 with a DC50 value of 1 nM in RKO cells. ACBI2 can be used in the research of lung cancer. price>
R-C-787 18:1DGS_NTA 1,2-dioleoyl-sn-glycero-3-[(n-(5-amino-1-carboxyphenyl)iminodiacetic acid) succenyl](nickel salt)is a customized product from Ruixi biotechCo.Ltd. price>
R-R-2487 GSK620 CAS No.2088410-46-0 GSK620/CAS No.2088410-46-0 is a potent and orally active pan-BD2 inhibitor with excellent broad selectivity, developability and in vivo oral pharmacokinetics. GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 shows an anti-inflammatory phenotype in human whole blood. price>
R-C-788 COOH-PEG1000-chitosan20000 Chitosan,also known as deacetylated chitin,is obtained by deacetylation of chitin, which widely exists in nature.Polyethylene glycol is an adduct of polyethylene oxide and water. price>
R-R-2488 MI-538 CAS No.1857417-10-7 MI-538/CAS No.1857417-10-7 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. price>
R-R-2489 CFT8634 CAS No.2704617-96-7 CFT8634/CAS No.2704617-96-7 is an oral activity degrader targeting BRD9 extracted from patent WO2021178920A1 compound 174. CFT8634 can be used for the research of synovial sarcoma and SMARCB1-deleted solid tumors. price>
R-C-790 Inorganic composite nanomaterials(Ag Mn Au) Nano materials refer to the macro materials formed by the accumulation of nanostructures in a certain way or dispersion in a certain matrix.Nano particles have special physical and chemical properties,which can be widely used in chemical industry,biology,medicine and other fields. price>
R-R-2490 INCB-057643 CAS No.1820889-23-3 INCB-057643/CAS No.1820889-23-3 is a novel, orally bioavailable BET inhibitor. price>
R-C-791 Oleic acid modified MnFe2O4 3NM The MnFe2O4 nanocrystals modified by oleic acid are prepared by pyrolysis at high temperature.They can be stably dispersed in toluene or cyclohexane with a concentration of 5mg/ml,which is provided by Ruixi biological company. price>
R-R-2491 ZL0454 CAS No.2229042-77-5 ZL0454/CAS No.2229042-77-5 is a potent and selective Bromodomain-containing protein 4 (BRD4) inhibitor with an IC50 of 49 and 32 nM for BD1 and BD2. price>
R-C-792 MPC-PEG2000-PHB4000 2-methacryloyloxyethyl phosphorylcholine polymer has been widely used in tissue engineering,artificial organ,immobilized enzyme,blood purification,biosensor and daily chemicals due to its excellent blood compatibility and histocompatibility. price>
R-R-2492 MI-136 CAS No.1628316-74-4 MI-136/CAS No.1628316-74-4 is an inhibitor of the menin-MLL protein-protein interaction (PPI), with an IC50 of 31 nM and a Kd of 23.6 nM. MI-136 shows to block AR signaling and has the potential for the study in castration-resistant tumors. price>
R-C-793 G0-C14 CAS:1510653-27-6 G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer.The particles are composed of three parts:outer peg surface,PLGA/G0-C14 layer,which play two roles:as a polymer matrix loaded with non-polar drugs,protecting and promoting siRNA molecules to stay in NP core and control drug release,and an aqueous inner core containing siRNA. price>