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Catalog	name	Description	price
R-C-835	PEG10K-PGA6K	The PEG10K-PGA6K provided by Ruixibio is a customized synthetic reagent.PEG was grafted onto polyglutamic acid with molecular weights of 1K,2K,5K,10K and 20K, and polyglutamate with molecular weights of 1500,7500,15K,30K,45k and 60K,and the corresponding repeat units of glutamic acid were10,50,100,200,300 and 400, respectively.	price>
R-R-2535	MI-2-2 CAS No.1454920-20-7	MI-2-2/CAS No.1454920-20-7 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity (Kd=22nM) and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation.	price>
R-C-836	NH2-PEG2K-Dopamine	NH2-PEG2K-Dopamine can be used to modify proteins,peptides and other materials and small molecules with carboxyl(-COOH)or other active groups that can react with primary amines.Amino(-NH2)can easily form stable amide bond with carboxyl group,and can also form amide bond with active ester(-NHS) in ph7-8.5. Polyethylene glycol can increase solubility and stability.It can also inhibit the non-specific binding of charged molecules on the modified surface.	price>
R-R-2536	TPOP146 CAS No.2018300-62-2	TPOP146/CAS No.2018300-62-2 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4.	price>
R-C-837	PEG-PAE（200nm）	PAEs poly(β-amino esters) is a kind of hydrophobic polymer,which is often combined with PEG as a amphiphilic copolymer.Peg-b-pae is used to prepare pH responsive micelles.When PAE is in acidic environment,it becomes soluble by protonation of amino groups in the structure.Based on the characteristic of charge transition under acidic condition of PAE,the acidic environment of tumor is used as a signal to trigger PAE to release the encapsulated drug.The main feature of MPEG PAEs is that we can start from the synthetic monomer of PAEs and change its structure,so that the amphiphilic copolymer of MPEG PAEs can destroy its structure and release drugs at different pH values.The pH response range is 5-8,that is,the micelle of MPEG PAEs can respond to ph5-5.3,ph5-5.5,ph6.5-6.8 and weak base 5-8 response.We can also modify various active groups or target molecules,such as folic acid,at the end of PEG.	price>
R-R-2537	M-89 CAS No.2363165-42-6	M-89/CAS No.2363165-42-6 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia.	price>
R-C-838	DSPE-TK-mPEG2K	DSPE-TK-mPEG,DSPE-TK-mPEG2K is a widely used phospholipid polyethylene glycol,which is an attractive amphiphilic lipid polymer conjugate,including hydrophilic peg and extremely hydrophobic fatty acids.In addition,DSPE-PEG is not only widely used as a key self-assembly material for anticancer drug delivery,but also as an additive for surface functionalized drug delivery systems.We can provide peg molecular weights of 1k, 2k, 3.4k, 5k, and 10k for this product.	price>
R-R-2538	Amredobresib CAS No.1610044-98-8	Amredobresib/CAS No.1610044-98-8 is a potent inhibitor of BET. Amredobresib inhibits the binding of bromodomains to acetylated lysines on histone H3 and H4 and thus acts as important regulators of gene transcription. Amredobresib is useful for the research of acute myeloid leukemia (AML) and cancer (extracted from patent WO2019145410A1 and WO2021175824A1).	price>
R-C-839	PCL2K-PEOz2K-COOH	PCL-PEOz,Poly(ε-caprolactone)-Poly(2-ethyl-2-oxazoline)is an amphiphilic AB blockcopolymer,PEOz can As apolymer long chain polymer,PEOz has good water solubility,flexibility andbiocompatibility,PEOzcan completely substitute PEG polyethylene glycol as drug carrier material,PCL-PEOz can be used to prepare PHresponsive micelle for drug delivery。	price>
R-R-2539	FL-411 CAS No.2118944-88-8	FL-411/CAS No.2118944-88-8 is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4.	price>
R-C-840	Drug entrapment in mesoporous silica(requimod) 50NM	Mesoporous silica nanoparticles (MSNs) have the advantages of uniform particle size distribution,good water dispersion,ultra-high specific surface area,narrow pore size distribution and large pore volume,and good biocompatibility.It can be used as an excellent carrier for fluorescent molecules,chemotherapy drugs,DNA / siRNA,protein and other guest molecules for biomedical applications such as diagnosis.	price>
R-R-2540	PROTAC BET Degrader-1 CAS No.2093386-22-0	PROTAC BET Degrader-1/CAS No.2093386-22-0 is a PROTAC connected by ligands for Cereblon and BET, decreasing BRD2, BRD3, and BRD4 protein levels at low concentration.	price>
R-C-841	Mesoporous silica encapsulated fluorescence (FITC) 50nm	Monodisperse mesoporous silica nanoparticles(MSNs)have the advantages of uniform size distribution,good water dispersibility,ultra-high specific surface area, narrow pore size distribution and large pore volume,and good biocompatibility.It can be used as an excellent carrier for fluorescent molecules,chemotherapy drugs, DNA/siRNA,protein and other guest molecules for biomedical applications such as diagnosis and treatment.	price>
R-R-2541	SNIPER(BRD)-1 CAS No.2095244-54-3	SNIPER(BRD)-1/CAS No.2095244-54-3, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively.	price>
R-C-842	PEG44-PCL60-TSPBA	Ruixibio can provide polyphylene glycol poly(ε-caprolactone)-tspbaPEG-PCL can be used in targeted drug research and widely used in protein carrier and ligand crosslinking.Polyethylene glycol polycaprolactone can be made into drug loaded microspheres,microcapsules,vesicles and micelles,which can be used to achieve sustained release and controlled release of drugs.It can also be used as a tissue engineering scaffold material with good hydrophilicity.	price>
R-R-2542	CeMMEC1 CAS No.440662-09-9	CeMMEC1/CAS No.440662-09-9 is an inhibitor of BRD4, and also has high affinity for TAF1, with an IC50 of 0.9 μM for TAF1, and a Kd of 1.8 μM for TAF1 .	price>
R-C-843	Ge11-PEG2000-PCL2000	Peptide ge11 is a small molecule peptide obtained by phage peptide library screening technology,which is composed of 11 amino acids (yhwygytpqnvi). Compared with natural macromolecular ligands,peptide ligands have the advantages of small molecular weight,low immunogenicity,easy diffusion and high targeting, which can meet the requirements of targeting tumor,and have no effect on the growth of tumor cells.Studies have shown that ge11 can specifically bind to EGFR,and ge11 has no effect on cell growth.The results showed that the liposomes modified with ge11 had high targeting to EGFR.	price>
R-R-2543	Molibresib besylate CAS No.1895049-20-3	Molibresib besylate (GSK 525762C; I-BET 762 besylate)/CAS No.1895049-20-3 is a BET bromodomain inhibitor with IC50 of 32.5-42.5 nM.	price>
R-C-844	DOPE-RB	DOPE-Rhodamine B(RB)，Rhodamine,also known as rhodamine or rose red,is a series of related fluorone heterocyclic compounds,which can be used as dyes.Among them,rhodamine 6G, Rhodamine B,rhodamine 123,rhodamine WT and so on are common.It can be used as gain medium for dye and dye laser.	price>
R-R-2544	PROTAC BET Degrader-10 CAS No.1957234-97-7	PROTAC BET Degrader-10/CAS No.1957234-97-7 is a potent BET protein BRD4 degrader extracted from patent WO2017007612A1, example 37, connected by ligands for Cereblon and BRD4, with a DC50 of 49 nM.	price>

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