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R-C-855 Fruquintinib Fruquintinib is an orally available,small molecule inhibitor of vascular endothelial growth factor receptors(VEGFRs),with potential anti-angiogenic and antineoplastic activities. price>
R-R-2555 PROTAC BET degrader-3 PROTAC BET Degrader-3 is a PROTAC connected by ligands for von Hippel-Lindau and BET. price>
R-C-856 Succinate vitamin E-PEI1.8k-mannose Vitamin E succinate(RRR-α-tocopheryl succinate,VES)is an esterified derivative of vitamin E.Vitamin E is one of the most effective anti-tumor compounds,but it has no obvious anti-tumor effect. price>
R-R-2556 LP99 CAS No.1808951-93-0 LP99/CAS No.1808951-93-0, an epigenetic probe, is a potent and selective inhibitor of the BRD7 and BRD9 bromodomains with a Kd of 99 nM against BRD9. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells. price>
R-C-857 5-hydroxydopamine-cisplatin-5-hydroxydopamine Cisplatin(CDDP)is a platinum containing anticancer drug,namely CIS dichlorodiamine combined with platinum(II).Its brownish yellow powder is a cell cycle nonspecific drug.It has therapeutic effect on sarcoma,malignant epithelial tumor,lymphoma and germ cell tumor. price>
R-R-2557 RVX-297 CAS No.1044871-04-6 RVX-297/CAS No.1044871-04-6 is a potent, orally active BET bromodomain inhibitor with selectivity for BD2. RVX-297 shows IC50s of 0.08, 0.05, and 0.02 μM for BRD2(BD2), BRD3(BD2), and BRD4(BD2), respectively. RVX-297 suppresses inflammatory gene expression in multiple immune cell types. RVX-297 is effective in acute inflammation and autoimmunity models. price>
R-C-858 SUPER FLUOR 555-NHS Cyanine dyes and their derivatives are often used in biological molecular labeling,fluorescence imaging and other fluorescent biological analysis.They are widely used to label peptides,proteins and nucleic acids.Cy7 is a near infrared cyanine dye. price>
R-R-2558 Bleximenib oxalate CAS No.2866179-95-3 Bleximenib oxalate/Menin-MLL inhibitor 24 (compound A) oxalate/CAS No.2866179-95-3 is a menin-mixed-lineage leukemia 1 (menin-MLL) inhibitor, and can be used for the research of cancer. price>
R-C-859 Alexa Fluor 488 Alexa fluor 488 is a kind of bright green fluorescent dye,and its excitation is very suitable for 488 nm laser line.In order to generate stable signals in imaging and flow cytometry,Alexa fluor 488 dye is not sensitive to pH in a wide range of moles.The probe with high fluorescence quantum yield and high photostability can detect low abundance biological structures with high sensitivity.Alexa-fluor488 dye molecules can attach to proteins at high molar ratio without significant self quenching,thus achieving brighter binding and more sensitive detection. price>
R-R-2559 PROTAC BRD4-binding moiety 1 CAS No.2101200-10-4 PROTAC BRD4-binding moiety 1/CAS No.2101200-10-4 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136). PROTAC BRD4-binding moiety 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. price>
R-C-860 Alexa Fluor 555 Probes with high fluorescence quantum yield and high photostability allow detection of low-abundance biological structures with great sensitivity. Invitrogen Alexa Fluor 555 dye molecules can be attached to proteins at high molar ratios without significant self-quenching,enabling brighter conjugates and more sensitive detection.We offer Alexa Fluor 555 dye conjugated to a variety of antibodies,peptides,proteins,tracers,and amplification substrates optimized for cellular labeling and detection.In addition,reactive dye forms and protein labeling kits are available to allow you to generate your own antibody conjugates or probes. price>
R-R-2560 653-47 hydrochloride CAS No.1224567-46-7 653-47 hydrochloride/CAS No.1224567-46-7, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 hydrochloride is also a very weak CREB inhibitor with IC50 of 26.3 μM. price>
R-C-861 DMSP Osmolar dimethylsulfonylpropionate(DMSP)of algae is the main precursor of marine dimethyl sulfide(DMS).DMS is a volatile sulfur compound,which affects atmospheric chemistry and global climate.DMSP may play an important role in the microbial ecology and biogeochemistry of the marine surface.The sulfur in DMSP is effectively bound to bacterial proteins(mainly methionine),and DMSP seems to be the main source of sulfur in marine planktonic bacteria. price>
R-R-2561 XX-650-23 CAS No.117739-40-9 XX-650-23/CAS No.117739-40-9 is a potent CREB inhibitor. XX-650-23inhibits CREB function through disruption of CBP-CREB interaction. XX-650-23 can be used for AML research. price>
R-C-862 PPS-PEG Amphiphilic block copolymers based on hydrophobic polysulfide(PPS)and hydrophilic polyether(PEG)have been used for solubilization and dispersion of single-walled carbon nanotubes(SWNTs).The high concentration aqueous dispersion was stable for several months. price>
R-R-2562 PBRM1-BD2-IN-5 CAS No.2819989-61-0 PBRM1-BD2-IN-5/CAS No.2819989-61-0 is a potent PBRM1 Bromodomain inhibitor with Kd values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5, respectively, and an IC50 value of 0.26 μM for PBRM1-BD2. PBRM1-BD2-IN-5 reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptide. PBRM1-BD2-IN-5 can be used to research anticancer. price>
R-C-863 PPS-PEI Polysulfides,any of a class of compounds,containing one or more clusters of sulfur that are connected by covalent bonds.Polyethyleneimine(PEI) had the best transfection effect.Polyethyleneimine(PEI)is an organic polymer with high charge density.Every two carbon atoms are separated,that is,the third atom is protonated amino nitrogen,which makes the polymer network function as an effective proton sponge at any pH value. price>
R-R-2563 INCB054329 CAS No.1628607-64-6 INCB054329/CAS No.1628607-64-6 is a potent BET inhibitor. price>
R-C-864 MPEG-CE6 CE6 is usually synthesized from pheophorbidic acid A.It is a good photosensitizer with similar biological activity to pheophorbidic acid a.CE6 is highly efficient in producing singlet oxygen because it is suitable for developing photodynamic therapy for tumors.CE6 is hydrophobic and easy to aggregate in solution. price>
R-R-2564 PROTAC BRD4 Degrader-1 CAS No.2133360-00-4 PROTAC BRD4 Degrader-1/CAS No.2133360-00-4 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC50 of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression. price>