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Catalog	name	Description	price
R-C-865	PEI-PBLG	PEI(10kd)-PBLG can encapsulate plasmids to form nanocomposites with particle size of 100~120nm,which is suitable for mediating plasmids into cells.The results showed that the nanoparticle complex had low sensitivity to transfection buffer,and could transfect all experimental cell lines in the presence of 10% serum,especially HeLa,followed by COS-7,Vero-E6 and ECV304;the transfection rate of PEI-PBLG(10kd)/pEGFP complex was 45.02%,which was higher than that of PEI (10kd)/pEGFP(29.16%);The cytotoxicity of PEI(10kd)-PBLG was significantly lower than Pei(25kd),Pei(10kd)and Pei(25kd)-PBLG.Pei(10kd)-PBLG,a new cationic polymer,not only improves the efficiency of Pei mediated gene transfection,but also reduces its cytotoxicity and improves its biocompatibility.	price>
R-R-2565	XP-524 CAS No.2344825-52-9	XP-524/CAS No.2344825-52-9 is a potent BET and EP300 inhibitor. XP-524 shows great tumoricidal activity in vivo. XP-524 prevents KRAS-induced, neoplastic transformation in vivo and extends survival in two transgenic mouse models of aggressive PDAC. XP-524 also enhances the presentation of self-peptide and tumor recruitment of cytotoxic T lymphocytes. XP-524 has the potential for the research of pancreatic ductal adenocarcinoma (PDAC).	price>
R-C-866	ZIF-8 coated chondroitinase ABC	ABC enzyme can degrade chondroitin sulfate A,chondroitin sulfate B(dermatan sulfate)and chondroitin sulfate C.The enzyme acts on the β 1-4 glycosides between disaccharide repeats and cuts them off through the mechanism of β elimination.The degradation products are oligosaccharides,mainly unsaturated disaccharides.Chondroitin sulfate can be quantified by the determination of unsaturated disaccharide products.	price>
R-R-2566	BET bromodomain inhibitor 1 CAS No.2411226-02-1	BET bromodomain inhibitor 1/CAS No.2411226-02-1 is an orally active, selective bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50 of 2.6 nM for BRD4. BET bromodomain inhibitor 1 binds to BRD2(2), BRD3(2), BRD4(1), BRD4(2), and BRDT(2) with high affinities (Kd values of 1.3 nM, 1.0 nM, 3.0 nM, 1.6 nM, 2.1 nM, respectively). bromodomain inhibitor 1 has anti-cancer activity.	price>
R-C-867	4arm-PEG5K-TK-COOH	Keto mercaptan is a reactive group of ROS.Keto mercaptan polymers are widely used in inflammation and tumor.Inflammation and tumor have high levels of ROS, which can break keto mercaptan chemical bond and realize drug release. Polyethylene glycol(PEG)is a kind of high molecular polymer,which has no irritation,slightly bitter taste,good water solubility and good compatibility with many organic components.	price>
R-R-2567	GSK1379725A CAS No.1802251-00-8	GSK1379725A/CAS No.1802251-00-8 is a selective BPTF ligand with a Kd of 2.8 uM, showing no binding activity for Brd4.	price>
R-C-868	Gold nanorods coated with erythrocyte membrane&Rhodamine	Gold nanorods can be used as a drug delivery carrier.Drugs can be attached to the surface of gold nanorods by physical adsorption or chemical conjugation,and can maintain the activity of drugs until they are released.Gold nanoparticles can be completely coated by cell membrane,and the coated particles can also prevent macrophage phagocytosis.As a complete cell membrane coated particle,it can also modify functional groups on its surface for drug targeted delivery.	price>
R-R-2568	UMB298 CAS No.2266569-73-5	UMB298/CAS No.2266569-73-5 is a potent and selective CBP/P300 bromodomain inhibitor.	price>
R-C-869	N-acetyl-d-glucosamine(NAG)-PLGA10K-PEG2k LA:GA=50:50	N-acetylglucosamine(NAG)is the basic component of many important polysaccharides in biological cells,especially the exoskeleton of crustaceans.It is an important premise for the synthesis of bifidus factor and has many important physiological functions in the organism.It is mainly used in clinic to enhance the function of human immune system,inhibit the overgrowth of cancer cells or fibroblasts, inhibit and treat cancer and malignant tumor,etc.	price>
R-R-2569	BRD4 Inhibitor-24 CAS No.309951-18-6	BRD4 Inhibitor-24 (compound 3U)/CAS No.309951-18-6 is a potent BRD4 inhibitor, BRD4 Inhibitor-24 shows antitumor activity against MCF7 and K652 cells, with IC50 values of 33.7 and 45.9 μM, respectively (extracted from patent CN107721975A).	price>
R-C-870	Oil soluble manganese dioxide nanoparticles（25nm）	The oil soluble manganese dioxide nanoparticles,with a diameter of about 25 nm, were dispersed in organic solvent(chloroform).	price>
R-R-2570	SR-0813 CAS No.2597186-19-9	SR-0813/CAS No.2597186-19-9 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC50 and EC50 values of 25 nM and 205 nM for ENL YEATS domain, respectively. SR-0813 has IC50 and EC50 values of 311 nM and 76 nM (CETSA) for AF9 YEATS domain, respectively. SR-0813 binds MAP3K19 with over 100-fold lower affinity (Kd=3.5 μM) than ENL YEATS (Kd=30 nM). SR-0813 can be used for the research of acute leukemia.	price>
R-C-871	COOH-PEG2K-Ge11	Peptide ge11 is a small molecule peptide obtained by phage peptide library screening technology,which is composed of 11 amino acids(yhwygytpqnvi).Ge11 can specifically bind to EGFR,and ge11 has no effect on cell growth.The results showed that the liposomes modified with ge11 had high targeting to EGFR.	price>
R-R-2571	EML 425 CAS No.1675821-32-5	EML425/CAS No.1675821-32-5 is a potent and selective CREB binding protein (CBP)/p300 inhibitor with IC50s of 2.9 and 1.1 μM, respectively.	price>
R-C-872	Cy5.5 labeled cationic liposomes	Ruixibio can provide blank liposome,fluorescent labeled liposome,liposome encapsulated drug or small molecule,liposome encapsulated protein or nucleic acid,liposome encapsulated polypeptide,liposome encapsulated fluorescent dye ICG photosensitizer,liposome encapsulated inorganic nanoparticles,liposome encapsulated quantum dot up conversion,Mir contrast liposome,and more Our reagents are only used for scientific research products,not for human body.	price>
R-R-2572	L-Moses dihydrochloride	L-Moses (L-45) dihydrochloride is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a Kd of 126 nM.	price>
R-C-873	T807-NH2	T807 is an effective tau protein imaging agent.Ruixibio can provide some inhibitors,peptides,phospholipids,fluorescent dyes,etc.,as well as high-end special customized products.	price>
R-R-2573	b-NF-JQ1 CAS No.2380000-55-3	β-NF-JQ1/CAS No.2380000-55-3 is a PROTAC that recruits Aryl Hydrocarbon Receptor E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity.	price>
R-C-874	Silybin biotin	Silymarin is an antioxidant derived from a plant called milk thistle.Silymarin can stabilize the membrane of liver cells,maintain the integrity of liver cells, prevent the toxin from penetrating and damaging the liver,accelerate the synthesis of DNA (deoxyribonucleic acid)of liver cells,prevent liver cirrhosis, fatty liver,cholangitis,psoriasis and other diseases,and inhibit the growth and differentiation of liver cancer,prostate cancer,breast cancer and cervical cancer cells.	price>
R-R-2574	GSK852 CAS No.2305842-30-0	GSK852/CAS No.2305842-30-0 is a highly potent, second bromodomain (BD2)-selective, bromo and extra-terminal domain (BET) inhibitor (pIC50 = 7.9).	price>

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