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Catalog	name	Description	price
R-R-2585	BRD4 Inhibitor-20 CAS No.2490311-14-1	BRD4 Inhibitor-20/CAS No.2490311-14-1 is a potent orally active bromodomain protein 4 (BRD4) inhibitor. BRD4 Inhibitor-20 has inhibitory activity for BRD4 (BD1) and BRD4 (BD2) with IC50 values of 19 nM and 28 nM, respectively. BRD4 Inhibitor-20 also has anti-proliferation activities in cancer cell lines. BRD4 Inhibitor-20 can be used for the research of kinds of cancer, such as colon cancer.	price>
R-C-886	GA-PEG3400-PLA2000	Glycyrrhetinic acid is a pentacyclic triterpenoid,which is obtained from glycyrrhizic acid hydrolysis of Glycyrrhiza glabra.Glycyrrhetinic acid can be regarded as a derivative of β-vanillin alcohol(oleanol type),which can be used as the glycoside ligand of glycyrrhetinic acid.Polyethylene glycol(PEG)is a kind of high molecular polymer,which has no irritation,slightly bitter taste,good water solubility and good compatibility with many organic components.It has excellent lubricity,moisture retention,dispersibility and adhesive.It can be used as antistatic agent and softener	price>
R-R-2586	DC-BPi-11 hydrochloride	DC-BPi-11 hydrochloride is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 hydrochloride shows remarkable inhibition against leukemia cell proliferation.	price>
R-C-887	Disulfide modified paclitaxel	Disulfide bond is a chemical bond that connects the sulfhydryl groups of two different cysteine residues in different peptide chains or the same peptide chain.Disulfide bond is a relatively stable covalent bond,which plays a role in stabilizing the spatial structure of peptide chain in protein molecules. Paclitaxel can make tubulin and tubulin dimer of microtubule lose dynamic balance,induce and promote tubulin polymerization,microtubule assembly,prevent depolymerization,so as to stabilize microtubule,inhibit the mitosis of cancer cells and trigger apoptosis,and then effectively prevent the proliferation of cancer cells and play an anti-cancer role.	price>
R-R-2587	BET-BAY 002 CAS No.1588521-78-1	BET-BAY 002/CAS No.1588521-78-1 is a potent BET inhibitor; shows efficacy in a multiple myeloma model.	price>
R-C-888	A549 membrane package PLGA@DOX	Doxorubicin(DOX)can maximize the efficacy and minimize dose limiting cardiotoxicity by controlled release of PEGylated nanoparticles.Using avidin biotin coupling system,the binding of PEG to PLA nanoparticles was controlled. The particle size was about 130 nm,and DOX was loaded to 5% (wt/wt).The encapsulation of nanoparticles will not affect the efficacy of DOX.	price>
R-R-2588	(R)-BAY1238097 CAS No.1564269-85-7	(R)-BAY1238097/CAS No.1564269-85-7 is the R-isomer with lower activity of BAY1238097. BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome.	price>
R-C-889	Glycyrrhizic acid nanoparticles（100nm）	Glycyrrhizic acid is an organic compound with the molecular formula of c42h62o16. As a drug,it has anti-inflammatory and anti allergic effects. Glycyrrhizic acid is the main active ingredient in Glycyrrhiza uralensis. Glycyrrhizic acid and its series of products can inhibit the growth of sarcoma and cancer cells,and the inhibition rate of AIDS is as high as 90%.It has a strong effect on increasing human immune function,and is also a good food additive and spice base material.	price>
R-R-2589	(Rac)-BAY1238097 CAS No.1564268-19-4	(Rac)-BAY1238097/CAS No.1564268-19-4 is a BET inhibitor, with an IC50 of 1.02 μM for BRD4. Used in cancer research.	price>
R-C-890	HSA-CY5	Human serum albumin (HSA)is the main plasma protein.It can bind with water,Ca (2 +),Na(+),K(+),fatty acids,hormones and drugs,and maintain the colloidal osmotic pressure of blood.Cy5 fluorescent dyes:dyes that emit fluorescence.Cy5 is very sensitive to its surrounding electronic environment,which can be used for enzyme detection.The conformational changes of attachment proteins can lead to positive or negative changes of fluorescence emission.Cyanine dye is a relatively old fluorescent dye,but it is the basis for other fluorescent dyes to improve their brightness,light resistance and quantum yield.	price>
R-R-2590	PROTAC BRD4 Degrader-11	PROTAC BRD4 Degrader-11 (compound 9a) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-11 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.23 nM and 0.38 nM, respectively.	price>
R-C-891	NH2-PEG5K-cRGDfK	Polyethylene glycol(PEG)is a kind of oligomer or polymer of ethylene oxide.The series of products are non-toxic,non irritating, slightly bitter in taste,with good water solubility and good compatibility with many organic components.	price>
R-R-2591	PROTAC BRD4 Degrader-12 CAS No.2417370-90-0	PROTAC BRD4 Degrader-12 (compound 9c)/CAS No.2417370-90-0 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-12 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.39 nM and 0.24 nM, respectively.	price>
R-C-892	Aminated mesoporous silica coated silver nanoparticles（100NM ）	Porous silica has the characteristics of large specific surface area,good chemical stability,good biocompatibility and controllable pore size.Currently, the main synthetic methods of mesoporous silica include sol gel method, hydrothermal method and so on.Silver nanoparticles have been widely used as catalyst materials,antistatic materials,low-temperature superconducting materials and medical antibacterial materials because of their ultra-high specific surface area,surface activity,conductivity and antibacterial properties.	price>
R-R-2592	MS31 CAS No.2366264-12-0	MS31/CAS No.2366264-12-0 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1. MS31 is not toxic to nontumorigenic cells.	price>
R-C-893	NH2-PEG2000-Cy5	Amine-Polyethylene glycol-cy5 is linked to drug molecules,peptides,DNA,proteins and small molecules with NHS and COOH.	price>
R-R-2593	PROTAC BRD4 Degrader-9 CAS No.2417370-42-2	PROTAC BRD4 Degrader-9 (compound 8a)/CAS No.2417370-42-2 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-9 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.86 nM and 7.6 nM, respectively.	price>
R-C-894	Triptolide-Biotin	Tripterygium wilfordii is an effective proteasome inhibitor,which can induce cancer cell apoptosis by inhibiting proteasome activity.Biotin was well tolerated.	price>
R-R-2594	Menin-MLL inhibitor 19 CAS No.2360487-93-8	Menin-MLL inhibitor 19/CAS No.2360487-93-8, a potent exo-aza spiro inhibitor of menin-mll interaction, example A17, extracted from patent WO2019120209A1. Menin-MLL inhibitor 19 can be used for the reseaech of various diseases, such as cancer, myelodysplastic syndrome (MDS) and diabetes.	price>
R-C-895	Simultaneous modification of folic acid / azide by sialic acid	Sialic acid is a general term for a class of derivatives of neuraminic acid in which amino hydrogen or hydroxyl hydrogen is substituted.It also refers to N-acetylneuraminic acid,one of the most important members of such compounds. Sialic acid is widely distributed in animal tissues and a small amount in other organisms,mainly as a component of glycoprotein and ganglioside.	price>

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