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Catalog	name	Description	price
R-C-926	PEGylation of picosetron on mesoporous silicon	PEG modified mesoporous silica nanoparticles(MSNs PEG)were used as drug delivery carriers for Danshensu.Through the method of CO hydrolysis and condensation with silane coupling agent,PEG grafting changed the drug release law and could effectively prolong the release time of Danshensu.With the increase of PEG grafting amount(mass fraction),the release rate of Danshensu could be effectively controlled.Click chemistry method can effectively control the grafting amount of PEG(mass fraction)and the release rate of Danshensu.	price>
R-R-2626	(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine CAS No.2347517-69-3	(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine/CAS No.2347517-69-3 is a dual target PROTAC that can not only target to the ubiquitination and degradation of Smad3 but also improve the HIF-α protein level. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine has a multi-path anti-fibrosis function and a renal protection function for research of renal anemia.	price>
R-C-927	poly(β-amino esters) Encapsulated DNA	The main synthesis method of PBAE is Michael addition reaction.The results showed that PBAE with different end groups had different gene transfection efficiency,and the hydrophilic amino group containing hydroxyl or extra amine had the best transfection efficiency;the amino group in the polymer was protonated under acidic conditions,and could bind to the drug or DNA containing negative ions,so that it could be effectively encapsulated.Because there were only tertiary amines in the straight chain PBAE,and there might be primary and secondary amines in the branched chain PBAE,When DNA nanoparticles were formed, the encapsulation ability of branched chain PBAE was stronger than that of straight chain PBAE,and the diameter of branched chain amino ester nanoparticles was smaller.	price>
R-R-2627	Trimethylamine N-oxide-d9 CAS No.1161070-49-0	Trimethylamine N-oxide-d9/CAS No.1161070-49-0 is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway.	price>
R-C-928	Biotin-THZ1	THZ1 is a selective CDK7 inhibitor that preferentially diminishes transcription in cancer cells.THZ1 has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain,providing an unanticipated means of achieving selectivity for CDK7.	price>
R-R-2628	Isoviolanthin CAS No.40788-84-9	Isoviolanthin/CAS No.40788-84-9, a flavonoid glycoside, could markedly inhibit TGF-β1-mediated migration and invasion by deactivating epithelial-mesenchymal transition (EMT) via the TGF-β/Smad and PI3K/Akt/mTOR pathways in HCC cells. Isoviolanthin exhibits no cytotoxic effects on normal liver LO2 cells.	price>
R-C-929	FA-hyaluronic acid-PAE（PAE20% FA7%）	Hyaluronic acid is a biochemical drug with high clinical value,which is widely used in cosmetics.It can play a unique role in protecting the skin.It can keep the skin moist,smooth,delicate,tender and elastic.It has the functions of anti wrinkle,anti wrinkle,beauty care and recovery of skin physiological function.	price>
R-R-2629	ALK5-IN-34 CAS No.2785430-90-0	ALK5-IN-34/CAS No.2785430-90-0 is an selective orally active activin receptor-like kinase (ALK) inhibitor. ALK5-IN-34 can inhibit the activity of ALK5-IN-34 with an IC50 value of ≤10 nM. ALK5-IN-34 also has inhibitory of tumor growth and can be used for the research of proliferative diseases, such as cancer.	price>
R-C-930	TTVP	TTVP (Tris (4-vinylphenyl) vinylphosphine) is a water-soluble red fluorescent material, while AIE represents Aggregation Induced Emission. Therefore, TTVP water-soluble red AIE aggregation induced luminescence material refers to a material that utilizes the molecular characteristics of TTVP to induce aggregation induced luminescence in a water-soluble environment.	price>
R-R-2630	Butaprost CAS No.69685-22-9	Butaprost/CAS No.69685-22-9 is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost is less activity against murine EP1, EP3 and EP4 receptors. Butaprost attenuates fibrosis by hampering TGF-β/Smad2 signalling.	price>
R-C-931	TTQ-F-NH2 95%	Amino functionalized near-infrared two zone probe ttq-f-nh2,near-infrared two zone(nir-ii,1000-1700 nm)fluorescence imaging,is a new optical imaging technology,with the advantages of high imaging resolution,high tissue penetration depth and weak autofluorescence,which can achieve accurate diagnosis of tumor.In order to realize the biological application of nir-ii fluorescent probe,hydrophobic fluorescent molecules are usually self-assembled by amphiphilic polymers to prepare water-soluble nanoparticles.Nir-i fluorescence imaging technology can also be used to guide the synergistic treatment of chemotherapy and phototherapy.	price>
R-R-2631	Pirfenidone-d5 CAS No.1020719-62-3	Pirfenidone-d5/CAS No.1020719-62-3 is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities.	price>
R-C-932	Sulfo-Cy7 maleimide	Sulfo-Cy7 maleimide is water soluble cyanine dye containing a maleimide group which is commonly reacted with thiols to form a thioester bond at pH 6.5 to 7.5. This NIR dye amine can be used to derivate various targets by the reaction with electrophilic groups,and by enzymatical reactions involving transamination.	price>
R-R-2632	Mongersen CAS No.1443994-46-4	Mongersen (GED-0301)/CAS No.1443994-46-4 is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals.	price>
R-C-933	Liposome surface modified DTPA / FITC	Liposome has a certain targeting property,while modified liposome has more active targeting property and stronger anticancer property,which is a new technology that has been studied more at present.	price>
R-R-2633	Elezanumab CAS No.1791416-49-3	Elezanumab (ABT-555; AE12-1Y-QL)/CAS No.1791416-49-3 is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC50 around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism.	price>
R-C-934	Graphene oxide grafted polypeptide（WKYMVm）	Polypeptides as receptor targeted anti-tumor carriers are more and more used to improve the effect of chemotherapy drugs.It has also been proved that polypeptides can improve the anti-tumor effect by enhancing the targeting specificity of drugs,enhancing the targeted absorption of drugs,and improving the original insoluble of some small molecule drugs.Peptide carrier targeting technology is known as a new generation of targeted drug development technology. Graphene oxide is the oxide of graphene,which is generally represented by go. Its color is brown yellow.The common products on the market are powder,flake and solution.	price>
R-R-2634	IDE 2 CAS No.1136466-93-7	IDE2/CAS No.1136466-93-7 is a small molecule cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) by activating the TGF-βsignaling pathway.	price>
R-D-935	DMG-PEG2000-transferrin	DMG-PEG2000,1,2-Dimyristoyl-sn-glycerol-methoxypolyethylene glycol-2000,is a lipid and peg conjugate.DMG-PEG2000 has been used with cationic lipids such as Dlin-MC3-DMA to form cationic nanoparticles that can encapsulate and deliver siRNA,mRNA,DNA or small molecules into the cytoplasm and represent the most advanced delivery platforms for systemic administration of active molecules.	price>
R-R-2635	Hydrochlorothiazid-d2 CAS No.1219798-89-6	Hydrochlorothiazid-d2/CAS No.1219798-89-6 is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect.	price>

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