Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-R-2666	Mavoglurant CAS No.543906-09-8	Mavoglurant (AFQ056)/CAS No.543906-09-8 is a potent, selective, non-competitive and orally active mGluR5 antagonist, with an IC50 of 30 nM. Mavoglurant shows a >300 fold selectivity for the mGluR5 over all targets (238) tested. Mavoglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-967	BocNH2-TK-NH2	Palladium catalyzed Buchwald Hartwig amination with BocNH2 as amine source and palladium catalyzed Hiyama coupling reaction of 2-trimethylsilylpyridine with brominated aromatic hydrocarbons.Palladium catalyzed Buchwald Hartwig amination with bocnh2 as amine source.The effects of catalyst,ligand,base,solvent and temperature on the reaction were investigated.	price>
R-R-2667	Dipraglurant CAS No.872363-17-2	Dipraglurant (ADX48621)/CAS No.872363-17-2 is a potent, selective, orally active and brain penetrant mGluR5 negative allosteric modulator (NAM), with an IC50 of 21 nM. Dipraglurant can reduce Levodopa-induced dyskinesia (LID) in vivo. Dipraglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-968	25 hydroxyvitamin D-nhs	25 hydroxyvitamin D(25 hydroxyvitamin d)is a kind of sterol hormone,which plays an important role in promoting the absorption of calcium in the intestine and maintaining its dynamic balance.It plays a key role in the growth and health of human bones.Vitamin D not only has skeletal effects,but also has non skeletal effects related to autoimmune diseases,diabetes,cardiovascular diseases,cell growth and differentiation.Vitamin D3 can be synthesized from skin tissue exposed to ultraviolet light.	price>
R-R-2668	L-Glutamine-15N-1 CAS No.59681-32-2	L-Glutamine-15N-1/CAS No.59681-32-2 is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>
R-C-969	N-nervonoyl-D-erythro-sphingosylphosphorylcholine, powder	Ceramide is a family of waxy lipid molecules.Ceramide is composed of a sphingosine molecule and a fatty acid molecule.Ceramide has a high concentration in the cell membrane of eukaryotic cells,because it is the main component of phospholipid bilayer-sphingomyelin.Phosphorylcholine is an amphoteric molecule composed of a hydrophilic head and a hydrophobic tail.Also known as lecithin. Phosphatidylcholine is one of the main components of phospholipids,which is extracted from plants.	price>
R-R-2669	RO0711401 CAS No.714971-87-6	RO0711401/CAS No.714971-87-6 is a selective and orally active positive allosteric modulator of mGlu1 receptor with an EC50 of 56 nM.	price>
R-C-970	Oil soluble nano iron star (particle size below 50nm)	Nano iron is the iron formed by the superposition of iron atoms one by one according to the nanometer level(e-9m).There is no difference in physical properties,but the difference is in chemical properties.For example,ordinary iron will not easily burn,but nano iron can spontaneously ignite in the air; ordinary iron has weak corrosion resistance,while nano iron has corrosion resistance.	price>
R-R-2670	Foliglurax monohydrochloride	Foliglurax monohydrochloride (PXT002331 monohydrochloride) is a highly selective and potent, brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) , with an EC50 of 79 nM. Antiparkinsonian effect.	price>
R-C-971	0prozomib(ONX0912) cas:935888-69-0	Oprozomib(onx 0912;pr047)is an oral biocompatible inhibitor, which can inhibit the ct-l activity of 20S proteasome (20S proteasome)β 5/LMP7 with IC50 of 36 nm /82 nm.	price>
R-R-2671	Basimglurant CAS No.802906-73-6	Basimglurant (RG7090)/CAS No.802906-73-6 is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM. Basimglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-972	MS-275 cas:209783-80-2	MS-275 is an inhibitor of HDAC (histone deacetylase) that preferentially inhibits HDAC1(IC50=300 nM)over HDAC3(IC50=8 μM).However,MS-275 does not inhibit HDAC8 (IC50>100μM).MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1),slowing cell growth,differentiation,and tumor development in vivo.Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs,like adriamycin,inhibitors of poly(ADP-ribose)polymerase(PARP),or inhibitors of heat shock protein 90 (Hsp90).	price>
R-R-2672	MSOP CAS No.66515-29-5	MSOP/CAS No.66515-29-5 is a selective group III metabotropic glutamate receptor antagonist with apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR.	price>
R-R-2673	MPEP CAS No.96206-92-7	MPEP/CAS No.96206-92-7 is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor antagonist, with an IC50 of 36 nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis. MPEP has anxiolytic-or antidepressant-like effects. MPEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-974	Obatoclax mesylate cas:803712-79-0	Obatoclax Mesylate is the mesylate salt of obatoclax,a synthetic small-molecule inhibitor of the bcl-2 family of proteins with potential pro-apoptotic and antineoplastic activities.Obatoclax binds to members of the Bcl-2 protein family,preventing the binding of these anti-apoptotic proteins to the pro-apoptotic proteins Bax and Bak and so promoting the activation of the apoptotic pathway in Bcl-2-overexpressing cells.The Bcl-2 family of proteins(bcl-2,bcl-xl, bcl-w,and Mcl-1)are overexpressed in a wide variety of cancers,including those of the lymphatic system,breast,lung,prostate,and colon.	price>
R-R-2674	VU0650786 CAS No.1809085-30-0	VU0650786/CAS No.1809085-30-0 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents.	price>
R-C-975	Vatalanib CAS 212141-54-3	Vatalanib,also called as PTK 787 or CGP 797870,is a small molecule that interacts reversibly and competitively at the ATP-binding site of the receptor tyrosine kinase domain to inhibit autophosphorylation.It targets all known VEGFR tyrosine kinases.	price>
R-R-2675	mGluR2 antagonist 1 CAS No.1432728-49-8	mGluR2 antagonist 1/CAS No.1432728-49-8 is a highly potent, orally bioavailable and selective class of mGluR2 negative allosteric modulator (IC50 of 9 nM) with excellent brain permeability.	price>
R-C-976	Quizartinib (AC220) cas:950769-58-1	Quizartinib(AC220)is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor,with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM,respectively.Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader.Quizartinib induces apoptosis.	price>
R-R-2676	L-Glutamine-15N CAS No.80143-57-3	L-Glutamine-15N/CAS No.80143-57-3 is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>

469470471472473474 475476477478479