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Catalog	name	Description	price
R-C-977	N6022 cas:1208315-24-5	N6022 is a new and first-class drug with strong inhibitory activity on S-nitrosoglutathione reductase (gsnor).Gsnor is an enzyme that plays an important role in the metabolism of S-nitrosoglutathione(GSNO)and the maintenance of nitric oxide(no)homeostasis.N6022 is a highly binding,specific and reversible gsnor inhibitor with IC50 of 8 nm and Ki of 2.5 nm.	price>
R-R-2677	CDPPB CAS No.781652-57-1	CDPPB/CAS No.781652-57-1 is a potent, selective and brain penetrant positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5), with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5. CDPPB may provide an approach for development of antipsychotic agents.	price>
R-C-978	PP1 (Src Inhibitor) cas:172889-26-8	PP 1 is a selective and potent Src family tyrosine kinase inhibitor.PP 1 studies have proved its ability to potently inhibit Lck and Fyn(FynT),IL-2 gene activation in T lymphocytes,and anti-CD3-induced protein tyrosine phosphorylation.Research indicates that PP 1 effectively blocks LPA and EGF-enhanced tyrosine phosphorylation,MAPK activation downstream of EGFR,Rsk-1 (p90RSK)activation by H2O2,Kit and Bcr-Abl tyrosine kinases,and degrades RETMEN2A and RETMEN2B oncoproteins via proteosomal targeting.Rat basophilic leukemia cell studies have shown that PP1 inhibits Fc εRI- and Thy-1-mediated activation.Structural studies have revealed that PP1 binds to the ATP-binding site in tyrosine kinases and Ser/Thr kinases.	price>
R-R-2678	JNJ-40411813 CAS No.1127498-03-6	JNJ-40411813 (ADX-71149)/CAS No.1127498-03-6 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. JNJ-40411813 has orally bioactivity and penetrate the blood-brain barriers. JNJ-40411813 has the potential property of anti-depression.	price>
R-C-979	Trelagliptin(syr472) cas:865759-25-7	Trelagliptin(SYR-472)succinate is a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM.Trelagliptin succinate improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM).	price>
R-R-2679	AMN082 CAS No.97075-46-2	AMN082/CAS No.97075-46-2, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects.	price>
R-C-980	TUS-68(SU6668,Orantinib)	Orantinib(TSU-68,SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay,but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation,little activity against IGF-1R,Met,Src,Lck,Zap70,Abl and CDK2;does not inhibit EGFR.	price>
R-R-2680	L-Glutamine-1-13C CAS No.159663-16-8	L-Glutamine-1-13C/CAS No.159663-16-8 is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>
R-C-981	A769662 cas:844499-71-4	A-769662 is a potent,reversible AMPK activator with EC50 of 0.8 μM in cell-free assays,little effect on GPPase/FBPase activity.	price>
R-R-2681	VU6005649 CAS No.2137047-43-7	VU6005649/CAS No.2137047-43-7 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively.	price>
R-C-982	TAK960 CAS:1137868-52-0	TAK-960 is an orally available,selective inhibitor of polo-like kinase 1 (PLK1),with an IC50 of 0.8 nM.TAK-960 also shows inhibitory activities against PLK2 and PLK3,with IC50s of 16.9 and 50.2 nM,respectively.TAK-960 inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts.	price>
R-R-2682	L-Glutamine-d5 CAS No.14341-78-7	L-Glutamine-d5/CAS No.14341-78-7 is the deuterium labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>
R-C-983	PS48 cas:1180676-32-7	PS 48 has been shown to be a PKB Kinase(phosphoinositide-dependent protein kinase-1,PDK1)activator(Kd=10.3 μM).Studies have indicated that this compound selectively binds to the PIF-binding pocket of PKB Kinase(PDK1).This is a distinct region separate from the ATP binding site.	price>
R-R-2683	L-Glutamine-15N2 CAS No.204451-48-9	L-Glutamine-15N2/CAS No.204451-48-9 is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>
R-C-984	Bosutinib(SKI-606) CAS:380843-75-4	Bosutinib(SKI-606)is a novel,dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays,respectively.Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR,MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK,p-S6,and p-STAT3.Bosutinib promotes autophagy.	price>
R-R-2684	VU6012962 CAS No.2313526-86-0	VU6012962/CAS No.2313526-86-0 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM) with an IC50 of 347 nM.	price>
R-C-985	Asunaprevir(BMS-650032) cas:630420-16-5	Asunaprevir(BMS-650032)is an orally bioavailable inhibitor of the hepatitis C virus enzyme serine protease NS3 that is necessary for protein processing required for viral replication.	price>
R-R-2685	AZD-8529 CAS No.1092453-15-0	AZD-8529/CAS No.1092453-15-0 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.	price>
R-C-986	(Obeticholic Acid)INT-747 CAS No. 459789-99-2	Obeticholic acid(INT-747)is a potent, selective and orally active FXR agonist with an EC50 of 99 nM.Obeticholic acid has anticholeretic and anti-inflammation effect.Obeticholic acid also induces autophagy.	price>
R-R-2686	LY3020371 hydrochloride CAS No.1377615-44-5	LY3020371 hydrochloride/CAS No.1377615-44-5 is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM. LY3020371 hydrochloride exerts an antidepressant-like signature in vivo.	price>

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