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Catalog	name	Description	price
R-C-987	FH535 cas:108409-83-2	FH535 is an inhibitor of β-catenin/Tcf-mediated transcription and an antagonist of ligand-dependent activation of PPARγ and PPARδ.1 At 15 µM,FH535 blocks the recruitment of β-catenin and GRIP1 to PPARγ and PPARδ.1 Presumably through these actions,FH535 is selectively toxic to some carcinoma cell lines expressing the Wnt/β-catenin pathway.1 FH535 is used to study the role of Wnt/β-catenin pathway in various cancer cell lines.	price>
R-R-2687	(S)-3,5-DHPG CAS No.162870-29-3	(S)-3,5-DHPG/CAS No.162870-29-3 is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with Ki values of 0.9 µM and 3.9 µM for mGluR1a and mGluR5a, respectively. (S)-3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia.	price>
R-C-988	ML323 cas:1572414-83-5	ML-323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay.The measured inhibition constants of ML-323 for the free enzyme(Ki)is 68 nM.	price>
R-R-2688	L-Cysteinesulfinic acid CAS No.1115-65-7	L-Cysteinesulfinic acid/CAS No.1115-65-7 is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.	price>
R-C-989	EMD-1214063 cas:1100598-32-0	EMD-1214063 is an inhibitor of met tyrosine kinase with IC50 of 4 nm.The selectivity of emd-1214063 to c-met is 200 times higher than that to irak4, TrkA,Axl,irak1 and mer.It has potential antitumor activity.It binds to met tyrosine kinase and destroys met signal transduction pathway,which may induce apoptosis in tumor cells overexpressing met tyrosine kinase.	price>
R-R-2689	DL-AP3 CAS No.5652-28-8	DL-AP3/CAS No.5652-28-8 is a competitive mGluR1 and mGluR5 antagonist. DL-AP3 is also an inhibitor of phosphoserine phosphatase. DL-AP3 has neuroprotective effect.	price>
R-C-990	Tivozanib (AV-951) cas:475108-18-0	Tivozanib(AV-951,KRN-951)is a potent and selective VEGFR inhibitor for VEGFR1/2/3 with IC50 of 30 nM/6.5 nM/15 nM,and also inhibits PDGFR and c-Kit,low activity observed against FGFR-1,Flt3,c-Met,EGFR and IGF-1R.	price>
R-R-2690	CPPG CAS No.183364-82-1	CPPG ((RS)-CPPG)/CAS No.183364-82-1 is a potent group II/III mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors.	price>
R-C-991	FG4592 CAS No. 808118-40-3	The hypoxia-inducible factor(HIF)pathway alters gene expression in response to low oxygen tension.Under normoxic conditions,HIF-specific prolyl hydroxylases (HIF-PHs)initiate the degradation of oxygen-sensitive HIF isoforms.As 2-oxoglutarate(2-OG)is a required co-factor for HIF-PH activity,analogs of 2-OG may inhibit HIF-PH and prevent HIF turnover.1 FG-4592 is an analog of 2-OG that has been developed as an inhibitor of HIF-PHs.While little has been published regarding the actions of this compound,similar HIF-PH inhibitors suppress HIF degradation and in this way induce erythropoietin expression,promoting erythropoiesis or preventing anemia in vivo.	price>
R-R-2691	Quisqualic acid CAS No.52809-07-1	Quisqualic acid (L-Quisqualic acid)/CAS No.52809-07-1, a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica.	price>
R-C-992	ww298	WW298 is the first effective inhibitor of the Mdmx–p53 interaction.	price>
R-R-2692	BMS-984923 CAS No.1375752-78-5	BMS-984923/CAS No.1375752-78-5, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (Ki = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling.	price>
R-C-993	WK23	WK23 is an inhibitor based on four aromatic groups and able to efficiently fill the binding pockets of MDM2/MDMX,its median inhibitory concentration(IC50) values to MDM2/MDMX are 1.17 and 36 uM,respectively.	price>
R-R-2693	CALP1 TFA	CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity.	price>
R-C-994	YH249	YH249 is the first highly specific,direct p300/β-catenin antagonist.	price>
R-R-2694	Fenobam CAS No.57653-26-6	Fenobam/CAS No.57653-26-6 is a selective, orally active, and brain-penetrant mGluR5 antagonist acting at an allosteric modulatory site (Kds of 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). Fenobam displays inverse agonist activity which blocks the mGlu5 receptor basal activity with an IC50 of 84 nM. Fenobam exerts anxiolytic activity.	price>
R-C-995	CID755673 cas:521937-07-5	CID755673 is a potent PKD inhibitor with IC50s of 182 nM,280 nM and 227 nM for PKD1,PKD2 and PKD3,respectively.	price>
R-R-2695	UPF-523 CAS No.168560-79-0	UPF-523 (AIDA)/CAS No.168560-79-0, a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis.	price>
R-C-996	GSK2636771 cas:1372540-25-4	GSK2636771 is a potent,orally bioavailable and selective inhibitor of PI3Kβ with >900-fold selectivity over PI3Kα/PI3Kγ and >10-fold over PI3Kδ.Sensitive to PTEN null cell lines.	price>
R-R-2696	Decoglurant CAS No.911115-16-7	Decoglurant (RO4995819)/CAS No.911115-16-7 is a negative allosteric modulator of mGluR2 and mGluR3. Decoglurant is developed as an antidepressant.	price>

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