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Catalog	name	Description	price
R-C-997	WHI-P154 cas:211555-04-3	WHI-P154 is a quinazoline derivative that exhibits immunosuppressive effects by selectively inhibiting JAK3 (IC50=1.8 μM versus IC50s>10 μM for JAK1 and JAK2).1It has been reported to inhibit additional kinases including EGFR (IC50= 4 nM)and VEGFR as well as the non-receptor tyrosine kinases,Abl,Lck,and Src.1WHI-P154 is cytotoxic to human glioblastoma cells(IC50=813 nM) and has been used to induce the differentiation of neuronal precursor cells.	price>
R-R-2697	Ro 01-6128 CAS No.302841-86-7	Ro 01-6128/CAS No.302841-86-7 is a positive allosteric modulator of mGluR1.	price>
R-C-998	AS-252424 cas:900515-16-4	AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform.It inhibits human recombinant PI3Kγ,α,β,and δ with IC50 values of 30,940, 20,000,and 20,000 nM respectively.	price>
R-R-2698	VU0422288 CAS No.1630936-95-6	VU0422288 (ML396)/CAS No.1630936-95-6 is a positive allosteric modulator of group III mGluRs. VU0422288 inhibits mGluRs with EC50s of 125 nM, 146 nM, and 108 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice.	price>
R-C-999	INCB28060 cas:1029712-80-8	INCB28060,a novel inhibitor of c-MET kinase.INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases.This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines.	price>
R-R-2699	CVN636 CAS No.2226732-62-1	CVN636/CAS No.2226732-62-1 is a potent, orally active and selective mGluR7 allosteric agonist with an EC50 value of 7 nM for hu mGluR7. CVN636 has central nervous system (CNS) permeability.	price>
R-C-1000	CNX1351 cas:1276105-89-5	CNX-1351 is a covalent inhibitor of PI3Kα(IC50=6.8 nM).1 It is selective for PI3Kα over PI3Kβ,-γ,and-δ(IC50s=166,240.3,and 3,020 nM,respectively),as well as PI3KC2A,PI3KC,PI4Kα,PI4Kβ,SPHK1,and SPHK2 (IC50s=>1 µM for all).CNX-1351 (500 nM)inhibits phosphorylation of Akt in SKOV3 cells.It inhibits the growth of SKOV3 and MCF-7 cancer cells(GI50s=77.6 and 54.7 nM,respectively).CNX-1351(100 mg/kg)inhibits Akt phosphorylation in mouse spleen.	price>
R-R-2700	trans-ACPD CAS No.67684-64-4	trans-ACPD/CAS No.67684-64-4, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons.	price>
R-C-1001	TAE684 (NVP-TAE684) cas:761439-42-3	TAE684(NVP-TAE684)is a selective inhibitor of ALK with IC50 value of 3 nM .TAE684(NVP-TAE684)is a potent ALK inhibitor and has a different selectivity with the reported ALK inhibitor crizotinib.When tested with ALCL cell lines—Karpas-299 and SU-DHL-1 expressing NPM-ALK,TAE684(NVP-TAE684)inhibited cell proliferation and cell apoptosis in dose-dependent manner.In lung cancer cell lines harboring wild-type,H694R or E1384K mutant ALKs,TAE684 showed effective inhibition on cell proliferation and phospho-Y1604 ALK expression of H694R or E1384K mutant ALK,but also to a degree higher than that of wild-type ALK.	price>
R-R-2701	FPTQ CAS No.864863-72-9	FPTQ/CAS No.864863-72-9 is potent mGluR1 antagonist with IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively. FPTQ has anti-oxidant and anti-inflammatory effects in vitro and in vivo.	price>
R-C-1002	NVP-AEW541 cas:474589-16-8	NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R(IC50=0.086 uM)and prevents IGF-1-mediated survival and proliferation of MCF-7 cells(IC50=0.16 and 1.64 uM,respectively).	price>
R-R-2702	ML337 CAS No.1443118-44-2	ML337/CAS No.1443118-44-2 is a selective and brain-penetrant negative allosteric modulator of mGlu3, with an IC50 of 593 nM. ML337 possesses a favorable dystrophia myotonica protein kinase (DMPK) and ancillary pharmacology profile. ML337 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1003	tomeglovir cas:233254-24-5	Tomeglovir is a potent anti-CMV agent,inhibiting processing of viral DNA-concatemers,with IC50s of 0.34 μM and 0.039 μM for HCMV and MCMV.	price>
R-R-2703	JNJ-46281222 CAS No.1254980-38-5	JNJ-46281222/CAS No.1254980-38-5 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71).	price>
R-C-1004	Empaglifilozin(BI-10773)	Empagliflozin is a potent,selective sodium glucose co-transporter-2 inhibitor that is in development for the treatment of type 2 diabetes.	price>
R-R-2704	L-Glutamine-13C5,15N2 CAS No.285978-14-5	L-Glutamine-13C5,15N2/CAS No.285978-14-5 is the 13C- and 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>
R-C-1005	TAS-103 cas:174634-08-3	TAS-103 is a dual inhibitor of DNA topoisomerase I/II,used for cancer research.	price>
R-R-2705	(E/Z)-SIB-1893 CAS No.6266-99-5	(E/Z)-SIB-1893/CAS No.6266-99-5 is a racemic compound of (E)-SIB-1893 and (Z)-SIB-1893 isomers. (E)-SIB-1893 is a selective non-competitive metabotropic glutamate subtype 5 receptor (mGluR5) antagonist.	price>
R-C-1006	PF-04217903 cas:956905-27-4	PF-04217903(PF-4217903)is a novel ATP-competitive small molecule inhibitor of c-Met kinases with the IC50 values from 3.1 nM to 142 nM.PF-04217903(PF-4217903) demonstrated>1000 fold selectivity for c-Met compared with>150 kinases, making it one of the most selective c-Met inhibitors described to date.PF-04217903(PF-4217903)inhibited tumor cell proliferation,survival,migration/invasion in MET amplified cell lines in vitro,and demonstrated marked antitumor activity in tumor models harboring either MET gene amplification or a HGF/c-Met autocrine loop at well-tolerated dose levels in vivo.	price>
R-R-2706	VU-29 CAS No.890764-36-0	VU-29/CAS No.890764-36-0 is a positive allosteric modulator of metabotropic glutamate 5 (mGlu5) receptor (EC50=9 nM and Ki=244 nM for rmGluR5). VU-29 is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM).	price>

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