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Catalog	name	Description	price
R-C-1017	JQ-1 CAS NO. 202592-23-2	JQ-1 carboxylic acid is a(+)-JQ1 derivative(a BET bromodomain inhibitor).JQ-1 carboxylic acid can be used as a precursor to synthesize PROTACs,which targets BET bromodomains.	price>
R-R-2717	ML353	ML353 is a selective ligand of mGlu5 silent allosteric modulator (SAM) with an Ki value of 18.2 nM. ML353 improves the affinity of common allosteric sites, 20-fold higher than the previous mGlu5 SAM tool compound 5mpep. ML353 has potential applications in solving the intrinsic activity of SAM in vivo or as a agent blocker. ML353 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1018	ONX0914(PR-957)	ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders,such as rheumatoid arthritis,inflammatory bowel disease and lupus.ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome.	price>
R-R-2718	CFMTI CAS No.864864-17-5	CFMTI/CAS No.864864-17-5 inhibits L-glutamate-induced intracellular Ca2+ mobilization in CHO cells expressing human and rat mGluR1a, with IC50s of 2.6 and 2.3 nM, respectively.	price>
R-C-1019	XEN-445 CAS NO. 1515856-92-4	XEN-445 is a novel,highly selective and efficient endothelial lipase(EL) inhibitor.Its IC50 for hel,hlpl and HHL are 0.237 μm,20 μ m and 9.5 μm, respectively.It showed good characteristics of ADME and PK,and showed the effect of increasing plasma HDLC concentration in mice.	price>
R-R-2719	(S)-3,4-DCPG CAS No.201730-11-2	(S)-3,4-DCPG/CAS No.201730-11-2 is a selective agonist of metabotropic glutamate receptor 8a (mGluR8a) with an EC50 of 31 nM in AV12-664 cells expressing human mGluR8.	price>
R-C-1020	Purmorphamine CAS No. 483367-10-8	Purmorphamine is a small molecule Hh agonist,it directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.Hedgehog agonist purmorphamine most significantly increased the neuronal differentiation of a human striatal NSC line (STROC05).Purmorphamine up-regulated gene expression of the mediators of Hh pathway,SMO,PTCH1,GLI1,and GLI2.The activation of Hh pathway by purmorphamine increased the expression of several genes. Purmorphamine triggers Hh signaling pathway in hMSCs,inducing an increase in the expression of a set of genes involved in the osteoblast differentiation program. The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 µM.	price>
R-R-2720	Oxomemazine CAS No.3689-50-7	Oxomemazine/CAS No.3689-50-7 is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties. Oxomemazine is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (Ki = 84 nM, M1 receptor) and low (Ki = 1.65 μM, M2 receptor) affinity sites. Oxomemazine an antihistamine and anticholinergic agent used for the study of cough treatment.	price>
R-C-1021	Ivacaftor (VX-770) CAS NO. 873054-44-5	Ivacaftor(VX-770)is a potent and orally bioavailable small molecule potentiator of cystic fibrosis transmembrane conductance regulator(CFTR).Studies in both G551D-and F508del-CFTR expressing cells have shown VX-700 combined with forskolin,but not VX-700 alone,has significantly increased CFTR-mediated Cl-secretion.The EC50 values of VX-700 in G551D- and F508del-CFTR are 100 nM and 25 nM,respectively.	price>
R-R-2721	(R)-ADX-47273 CAS No.851881-59-9	(R)-ADX-47273/CAS No.851881-59-9 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .	price>
R-C-1022	PD0332991（Palbociclib） CAS No. 571190-30-2	Palbociclib(PD 0332991)is a selective CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM,respectively.Palbociclib has the potential for ER-positive and HER2-negative breast cancer research.	price>
R-R-2722	VU0155041 CAS No.1093757-42-6	VU0155041/CAS No.1093757-42-6 is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively.	price>
R-C-1023	CW069 CAS No. 1594094-64-0	CW069 is a novel allosteric inhibitor of microtubule kinesin hset.Its IC50 value is 75±20μm,which is significantly selective compared with KSP.IC50 value:75 ± 20μm[1]target:hset-cw069 has obvious selectivity for hset in vitro.The IC50 value of cw069 for hset was 75±20μm,and the selectivity of cw069 for KSP reached the experimental limit.CW069 induced a small but significant increase in the multipolar spindle of MDA-MB-231,which was consistent with the intermediate level of centrosome in untreated cells.After cw069 treatment,the number of multipolar spindles increased in bt549 cells.	price>
R-R-2723	VU0483605 CAS No.1623101-11-0	VU0483605/CAS No.1623101-11-0 is a potent and brain-penetrated mGlu1 receptor positive allosteric modulator (PAM). VU0483605 shows excellent mGlu1 PAM activity at both human and rat, with EC50 values of 390 and 356 nM, respectively.	price>
R-C-1024	TMP269 CAS No. 1314890-29-3	TMP269 is a novel and selective class IIa histone deacetylase(HDAC)inhibitor with IC50s of 157 nM,97nM,43 nM and 23 nM for HDAC4,HDAC5,HDAC7 and HDAC9, respectively.	price>
R-R-2724	AZ 12216052 CAS No.1290628-31-7	AZ 12216052/CAS No.1290628-31-7 is a mGluR8 positive allosteric modulator, and helps mGluR8 modulate signaling inputing to retinal ganglion cells. AZ 12216052 exhibits antianxiety effect.	price>
R-C-1025	Nexturastat A CAS No. 1403783-31-2	Nexturastat A is a selective inhibitor of histone deacetylase 6(HDAC6)with IC50 value of 5.2 nM.Nexturastat A is a HDAC inhibitor.It was developed by structural modification of aryl urea HDACIs.The inhibitory activity of Nexturastat A is most potent against HDAC6 with IC50 value of 5.2 nM. Besides that,Nexturastat A also shows inhibition of other HDACs with IC50 values of 3.02,6.92,6.68,9.39, 11.7,4.46,0.954,6.72,7.57and5.14μM for HDAC1,2,3,4,5,7,8,9,10 and 11,respectively.Nexturastat A has been shown to suppress cell proliferation and promote apoptosis in B16 murine melanoma cells.	price>
R-R-2725	LSN2463359 CAS No.1401031-52-4	LSN2463359/CAS No.1401031-52-4 is positive allosteric modulator of metabotropic glutamate 5 (mGlu5). LSN2463359 attenuates aspects of the behavioral response to administration of the competitive NMDA receptor antagonist. LSN2463359 selectively attenuates reversal learning deficits observed in the neurodevelopmental MAM E17 model. LSN2463359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1026	kartogenin CAS No. 4727-31-5	Kartogenin(KGN)is an inducer of differentiation of human mesenchymal stem cells into chondrocytes,with an EC50 of 100 nM. Kartogenin binds filamin A,disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ),and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program.Kartogenin can be used for the research of osteoarthritis(OA).	price>
R-R-2726	LY2812223 CAS No.1311385-20-2	LY2812223/CAS No.1311385-20-2 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).	price>

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