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Catalog	name	Description	price
R-C-1027	Deferitrin C AS NO. 239101-33-8	Deferitrin is a novel, orally available iron chelator.Deferitrin may be useful as chelation monotherapy or as part of combination or doublet chelation therapy for the treatment of severe iron overload in patients with beta-thalassemia major if its favorable pharmacokinetic profile,efficacy,safety and tolerability are confirmed in more extensive clinical trials.A phase I/II clinical trial that began in September 2003 has reportedly completed recruitment.Deferitrin was safe,well-tolerated,and well-absorbed either with food and fasting in beta-thalassemia patients.Renal excretion of deferitrin uncomplexed with iron was similar to that seen in preclinical studies,which predict iron excretion to be via the fecal route.Further studies are ongoing to define the effect of deferitrin on iron balance.	price>
R-R-2727	LY487379 CAS No.353231-17-1	LY487379/CAS No.353231-17-1 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 potentiates glutamate-stimulated [35S]GTPγS binding with EC50 values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research.	price>
R-C-1028	SVT-40776 CAS NO. 385367-47-5	SVT-40776 is a potent inhibitor of M(3)receptor-related detrusor contractile activity.SVT-40776 is highly selective for M(3) over M(2)receptors(Ki=0.19 nmol.L(-1)for M(3)receptor affinity).SVT-40776 was the most potent in inhibiting carbachol-induced bladder contractions of the anti-cholinergic agents tested, without affecting atrial contractions over the same range of concentrations. SVT-40776 exhibited the highest urinary versus cardiac selectivity(199-fold).	price>
R-R-2728	E4CPG CAS No.170846-89-6	E4CPG ((RS)-ECPG)/CAS No.170846-89-6 is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation.	price>
R-C-1029	Ansamitocin p-3 (Maytansinol isobutyrate, NSC292222) CAS No. 66584-72-3	Ansamitocin P-3 is a microtubule inhibitor,it is also a macrocyclic antitumor antibiotic.Ansamitocin P3 inhibits the proliferation of MCF-7,HeLa,EMT-6/AR1 and MDA-MB-231 cells in culture.Further,Ansamitocin P3 binds to purified tubulin in vitro with a dissociation constant Kd value of 1.3±0.7 µM.	price>
R-R-2729	YM-298198 hydrochloride CAS No.1216398-09-2	YM-298198 hydrochloride/CAS No.1216398-09-2 is a high-affinity, selective, orally active, and non-competitive antagonist of metabotropic glutamate receptor type 1 (mGluR1). YM-298198 hydrochloride can be used for the research of neurological disorders.	price>
R-C-1030	Valrubicin CAS No. 56124-62-0	Valrubicin is a chemotherapy drug used to treat bladder cancer.Valrubicin is a chemotherapy agent,inhibits TPA-and PDBu-induced PKC activation with IC50s of 0.85 and 1.25μM,respectively.	price>
R-R-2730	FTIDC CAS No.873551-53-2	FTIDC/CAS No.873551-53-2 is an orally active, noncompetitive, selective allosteric metabotropic glutamate receptor (mGluR) 1 antagonist with an IC50 of 5.8 nM for human mGluR1a. FTIDC has no species differences in its antagonistic activity on recombinant human, mouse, and rat mGluR1.	price>
R-C-1031	Pirarubicin CAS No. 72496-41-4	Pirarubicin is an analogue of the anthracycline anti-neoplastic doxorubicin. Intercalates into DNA and interacts with Topo II(topoisomerase II)and supressing DNA replication.	price>
R-R-2731	LY2979165 CAS No.1311385-32-6	LY2979165/CAS No.1311385-32-6 is the alanine proagent of 2812223, a selective and potent orthosteric mGlu2 receptor agonist.	price>
R-C-1032	epothilone A CAS No. 152044-53-6	Epothilone A acts by stabilising microtubule formation at the taxol binding site and causes cell cycle arrest at the G2/M transition,leading to cytotoxicity.	price>
R-R-2732	CPPHA CAS No.693288-97-0	CPPHA/CAS No.693288-97-0 is potent and selective positive allosteric modulator (PAM) of the mGluR5 and mGluR1 (metabotropic glutamate receptor). CPPHA can potentiate responses of mGluR5 and mGluR1 to activation of these receptors. CPPHA is developed for the research of central nervous system disorders.	price>
R-C-1033	Moxidectin CAS No. 113507-06-5	Moxidectin(ProHeart 6;CL301423;Cydectin)is an anthelmintic drug which kills parasitic worms(helminths),and is used for the prevention and control of heartworm and intestinal worms.	price>
R-R-2733	BMT-145027 CAS No.2018282-44-3	BMT-145027/CAS No.2018282-44-3 is an mGluR5 positive allosteric modulator without inherent agonist activity, exhibits an EC50 of 47 nM.	price>
R-C-1034	Ulixertinib (BVD-523) CAS No. 869886-67-9	Ulixertinib is an orally available inhibitor of extracellular signal-regulated kinase(ERK)1 and 2,with potential antineoplastic activity.Upon oral administration,ulixertinib inhibits both ERK 1 and 2,thereby preventing the activation of ERK-mediated signal transduction pathways.This results in the inhibition of ERK-dependent tumor cell proliferation and survival.The mitogen-activated protein kinase(MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.	price>
R-R-2734	Valiglurax CAS No.1976050-09-5	Valiglurax (VU0652957)/CAS No.1976050-09-5 is a potent, orally active and selective mGlu4 positive allosteric modulator with EC50 values of 64.6 nM and 197 nM for hmGlu4/Gqi5 and rmGlu4 GIRK, respectively. Valiglurax is a central nervous system (CNS) penetrant.	price>
R-C-1035	ALK inhibitor 2 CAS NO. 761438-38-4	ALK inhibitor 2(compound 18)is a potent pyrimidin ALK inhibitor.ALK inhibitor 2 is a potent inhibitor of testis-specific serine/threonine kinase 2(TSSK2;IC50=37 nM)and focal adhesion kinase(FAK;IC50=5 nM).	price>
R-R-2735	VU0360172 CAS No.1310012-12-4	VU0360172/CAS No.1310012-12-4 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice. VU0360172 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1036	MK8745 CAS No. 885325-71-3	MK-8745 is a novel Aurora-A specific inhibitor.It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.	price>
R-R-2736	L-AP4 monohydrate CAS No.2247534-79-6	L-AP4 (L-APB) monohydrate/CAS No.2247534-79-6 is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.	price>

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