Xi'an ruixi Biological Technology Co

Home > Keywords >

Catalog	name	Description	price
R-R-2737	LY2389575 hydrochloride CAS No.885104-09-6	LY2389575 hydrochloride/CAS No.885104-09-6 is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels.	price>
R-C-1038	Vandetanib (ZD6474) CAS No. 443913-73-3	Vandetanib(ZD6474)is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay.It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM,respectively.Not sensitive to PDGFRβ,Flt1,Tie-2 and FGFR1 with IC50 of 1.1-3.6 μM.No activity against MEK,CDK2,c-Kit,erbB2,FAK,PDK1,Akt and IGF-1R with IC50 above 10 μM. Vandetanib(ZD6474)increases apoptosis and induces autophagy by increasing the level of reactive oxygen species(ROS).	price>
R-R-2738	VU0080241 CAS No.393845-24-4	VU0080241/CAS No.393845-24-4 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 4 (mGluR4), with an EC50 of 4.6 μM.	price>
R-C-1039	GSK126 CAS No. 1346574-57-9	GSK126 is a potent,highlyselective,S-adenosyl-methionine-competitive,small-molecule inhibitor of EZH2 methyltransferase activity,decreases global H3K27me3 levels and reactivates silenced PRC2 target genes.	price>
R-R-2739	VU-1545 CAS No.890764-63-3	VU-1545/CAS No.890764-63-3 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM) with a Ki of 156 nM and an EC50 of 9.6 nM.	price>
R-C-1040	MX1013 CAS NO. 582316-00-5	MX1013 is a dipeptide pan-caspase inhibitor that inhibits caspase-1,caspase-3, and caspase-6,7,8,and 9.	price>
R-R-2740	MNI137 CAS No.946619-21-2	MNI137/CAS No.946619-21-2 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization.	price>
R-C-1041	Mitomycin C CAS:50-07-7	Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis,used to treat different cancers.Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.	price>
R-R-2741	ML254 CAS No.1428630-86-7	ML254/CAS No.1428630-86-7 is a potent mGlu5 potentiator, with EC50 and pEC50 of 9.3 nM and 8.03 nM for rat mGlu5, respectively. ML254 can be used for researching schizophrenia. ML254 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1042	Lomitapide (AEGR-733, BMS-201038） CAS No. 182431-12-5	Lomitapide is a small-molecule,microsomal triglyceride transfer protein(MTP) inhibitor,for the treatment of both familial and primary hypercholesterolemia. Oral,once-daily lomitapide will be targeted at patients resistant to HMG-CoA reductase inhibitors(statins)either due to abnormalities in liver function or to discontinuation because of muscle pain.	price>
R-R-2742	DCG-IV CAS No.147782-19-2	DCG-IV/CAS No.147782-19-2 is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects.	price>
R-C-1043	Rolapitant(sch619734) CAS No. 552292-08-7	SCH-619734 is an orally bioavailable,centrally-acting,selective neurokinin 1 receptor(NK1-receptor)antagonist with a Ki of 0.66 nM.Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system,thereby inhibiting the binding of the endogenous ligand,substance P(SP).Rolapitant is active at 0.1 and 1 mg/kg in both acute and delayed emesis models in ferrets,respectively.	price>
R-R-2743	L-Cysteinesulfinic acid monohydrate CAS No.207121-48-0	L-Cysteinesulfinic acid monohydrate/CAS No.207121-48-0 is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.	price>
R-C-1044	p7c3-a20 CAS:1235481-90-9	P7C3-A20 is a derivative of P7C3that has proneurogenic and neuroprotective activity.It increases proliferation in the subgranular zone(SGZ)of the adult mouse dentate gyrus in a dose-dependent manner when administered at doses ranging from 0.1 to 10 µM.It also protects U2OS cells from calcium-induced mitochondrial dissolution.In a rat model of traumatic brain injury,P7C3-A20 decreases contusion volume,increases proliferation in the SGZ,and decreases the latency to reach the platform in the Morris water maze to sham surgery control levels.It also prevents or reverses dopaminergic cell death and motor deficits in a 6-OHDA rat model of Parkinson disease.	price>
R-R-2744	(RS)-PPG CAS No.120667-15-4	(RS)-PPG/CAS No.120667-15-4 is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity.	price>
R-C-1045	Ticagrelor (AZD6140) CAS:274693-27-5	Ticagrelor is a reversible antagonist of the platelet purinergic P2Y12 receptor (Ki=14 nM;IC50=1.8μM),which is the main receptor responsible for ADP-induced platelet aggregation.1,2It functions by directly changing the conformation of the P2Y12 receptor to inhibit ADP binding.3Formulations containing ticagrelor have been used to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome.	price>
R-R-2745	VU0364770 hydrochloride CAS No.1414842-70-8	VU0364770 hydrochloride/CAS No.1414842-70-8 is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 hydrochloride exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 hydrochloride also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively.	price>
R-C-1046	Tofacinix CAS:477600-75-2	Tofacitinib is an orally available inhibitor of Janus kinases(JAK),with immunomodulatory and anti-inflammatory activities.Upon administration, tofacitinib binds to JAK and prevents the activation of the JAK-signal transducers and activators of transcription(STAT)signaling pathway.This may decrease the production of pro-inflammatory cytokines,such as interleukin (IL)-6,-7,-15,-21,interferon-alpha and -beta, and may prevent both an inflammator response and the inflammation-induced damage caused by certain immunological diseases.JAK kinases are intracellular enzymes involved in signaling pathways affecting hematopoiesis,immunity and inflammation.	price>
R-R-2746	mGluR3 modulator-1 CAS No.374548-18-2	mGluR3 modulator-1 (compound 3)/CAS No.374548-18-2 is a mGluR3 modulator, with an EC50 of 1-10 μM in HEK293T-mGluR-Gqi5 Calcium Mobilization Assay.	price>
R-C-1047	lurasidone CAS: 367514-87-2	Lurasidone(SM-13496)is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki=1nM and Ki=0.5 nM,respectively.It also has high affinity for serotonin 5-HT7 receptors(Ki=0.5 nM),partial agonist activity at 5-HT1A receptors(Ki=6.4 nM)and lacks affinity for histamine H1 and muscarinic M1 receptors.	price>

476477478479480481 482483484485486