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Catalog	name	Description	price
R-C-1058	INH1 CAS:313553-47-8	INH1 specifically disrupts the Hec1/Nek2 interaction via direct Hec1 binding. INH1 shows promising cancer inhibition activity both in vitro and in vivo.	price>
R-R-2758	A-841720 CAS No.869802-58-4	A-841720/CAS No.869802-58-4 is a potent, non-competitive and selective mGlu1 receptor antagonist with an IC50 of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC50 of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has the potential for chronic pain research.	price>
R-C-1059	INH6 CAS：1001753-24-7	INH6 is a potent Hec1 inhibitor,which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.	price>
R-R-2759	XAP044 CAS No.196928-50-4	XAP044/CAS No.196928-50-4 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms.	price>
R-C-1060	E7010(ABT-751) CAS：141430-65-1	ABT-751(E7010)binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules,not a substrate for the MDR transporter and is active against cell lines resistant to vincristine,doxorubicin,and cisplatin.	price>
R-R-2760	(±)-LY367385 CAS No.198419-90-8	(±)-LY367385/CAS No.198419-90-8 is the racemate of LY367385. LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a.	price>
R-C-1061	AC55541 CAS：916170-19-9	AC-55541 is a highly selective protease-activated receptor 2(PAR2)agonist (pEC50=6.7),displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation.	price>
R-R-2761	Ro 67-4853 CAS No.302841-89-0	Ro 67-4853/CAS No.302841-89-0 is a positive allosteric modulator (PAM) of mGluR1 (pEC50=7.16 for rmGlu1a receptor). Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with the transmembrane domain (TMD) of the receptor. Ro 67-4853 potentiates sensory synaptic responses to repetitive vibrissa stimulation.	price>
R-C-1062	ZK-811752(BX-471) CAS:217645-70-0	BX471(ZK-811752)is an orally active, potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM,and exhibits 250-fold selectivity for CCR1 over CCR2,CCR5 and CXCR4.	price>
R-R-2762	TC-N 22A CAS No.1314140-00-5	TC-N 22A/CAS No.1314140-00-5 is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo.	price>
R-C-1063	PFI-3 CAS:1819363-80-8	PFI-3 is a selective chemical probe for SMARCA bromodomains,including SMARCA2, SMARCA4 and PB1(5)bromodomains.	price>
R-R-2763	O-Phospho-L-serine-13C3,15N CAS No.2734706-69-3	O-Phospho-L-serine-13C3,15N/CAS No.2734706-69-3 is the 13C- and 15N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.	price>
R-C-1064	LY2835219 CAS：1231929-97-7	LY2835219 mesylate is a potent and selective CDK4/6 dual inhibitor with potential antineoplastic activity.CDK4/6 dual inhibitor LY2835219 has been shown in vitro to be a selective ATP-competitive inhibitor of CDK4/6 that inhibits phosphorylation of the Rb tumor suppressor protein and thereby induces G1 cell cycle arrest.Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition,thereby arresting the cell cycle in the G1 phase,suppressing DNA synthesis and inhibiting cancer cell growth.LY2835219 is being investigated in a phase I clinical trial and in a clinical trial for the treatment of mantle cell lymphoma.	price>
R-R-2764	(S)-4CPG CAS No.134052-73-6	(S)-4CPG ((S)-4-Carboxyphenylglycine)/CAS No.134052-73-6 is a potent mGluR2 agonist. (S)-4CPG reduces hyperalgesia and allodynia associated with sciatic nerve contraction injury in rats. (S)-4CPG can be used in research on neurological diseases.	price>
R-C-1065	D-64131(sc-203908) CAS:74588-78-6	D-64131 is an orally active tubulin inhibitor,with an IC50 of 0.53 μM for tubulin polymerization.D-64131 has antimitotic activity.D-64131 can be used for cancer research.	price>
R-R-2765	CBiPES CAS No.353235-01-5	CBiPES/CAS No.353235-01-5 is a potent mGlu2 positive allosteric modulator with an EC50 value of 92.8 nM. CBiPES attenuates stress-induced hyperthermia and Phencyclidine-induced hyperlocomotor activity. CBiPES can be used for research of neurological diseases.	price>
R-C-1066	JW55 CAS：664993-53-7	JW 55 efficacy causes stabilization of Axin2.JW 55 also decreases canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines.Inhibitor of the PARP domain of tankyrase 1 and 2(TNKS1/2).JW 55 inhibits the β-catenin signaling pathway.It Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines;JW 55 reduces cell cycle progression and proliferation in SW480 cells in vitro.	price>
R-R-2766	SIB-1757 CAS No.31993-01-8	SIB-1757/CAS No.31993-01-8 is a highly selective and noncompetitive antagonist of mGlu5 receptor with an IC50 of 0.4 μM.	price>
R-C-1067	7-ACC2 CAS:1472624-85-3	7ACC2 is a potent monocarboxylate transporter(MCT)inhibitor with an IC50 of 11 nM for inhibition of[14C]-lactate influx.7ACC2 is also a potent inhibitor of mitochondrial pyruvate transport.7ACC2 is an anticancer agent through inhibition of lactate flux.	price>
R-R-2767	L-Glutamine-13C5,15N2,d5 CAS No.2123439-02-9	L-Glutamine-13C5,15N2,d5/CAS No.2123439-02-9 is the deuterium, 13C-, and 15-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>

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