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Catalog	name	Description	price
R-C-1068	Gandotinib (LY2784544) CAS:1229236-86-5	LY2784544 is a small molecule selective mutant JAK2 kinase inhibitor with an IC50 of 68 nM.The antiproliferative activity of LY2784544 and its ability to induce apoptosis were examined by Celltiter-Glo Cell Viability and Caspase-Glo 3/7 Apoptosis Assays,respectively.In the in vitro tests using Ba/F3 cells expressing either wild type or V617F mutant JAK2,it potently inhibited the JAK2 V617F-STAT5 signaling at a concentration that was 41-fold lower than that required to inhibit IL-3-activated wild type JAK2-STAT5 signaling(IC50=0.055 uM for JAK2 V617F vs.2.26 uM for WT JAK2).Similarly in the proliferation assay, LY2784544 selectively inhibited the JAK2 V617F-driven cell proliferation(IC50= 0.068 uM).Inhibition of JAK2 V617F signaling correlated well with the induction of apoptosis(EC50=0.113 uM)in Ba/F3 cell model.	price>
R-R-2768	CBiPES hydrochloride CAS No.856702-40-4	CBiPES hydrochloride/CAS No.856702-40-4 is a mGlu2 receptor positive allosteric modulator (EC50: 92.8 nM). CBiPES hydrochloride attenuates stress-induced hyperthermia and PCP-induced hyperlocomotor activity. CBiPES hydrochloride can be used for research of neurological disease.	price>
R-C-1069	REVERSINE CAS：656820-32-5	Reversine is a potent human A3 adenosine receptor antagonist with Ki of 0.66 μM, and a pan-aurora A/B/C kinase inhibitor with IC50 of 12 nM/13 nM/20 nM,respectively.Also used for stem cell dedifferentiation.	price>
R-R-2769	(S,S)-BMS-984923 CAS No.1375752-77-4	(S,S)-BMS-984923/CAS No.1375752-77-4 is a less active (S,S)-enantiomer of BMS-984923. (S,S)-BMS-984923 shows an EC50 >1μM for mGluR5 receptor. BMS-984923 is a potent mGluR5 silent allosteric modulator. (S,S)-BMS-984923 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1070	SU9516 CAS：377090-84-1	SU9516 is a potent,selective cdk2 inhibitor.It inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest.	price>
R-R-2770	ML289 CAS No.1382481-79-9	ML289 (VU0463597)/CAS No.1382481-79-9 is a potent, selective, and CNS-penetrant mGlu3 (IC50=0.66 μM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5. ML289 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1071	yk-4-279 CAS:1037184-44-3	YK-4-279 is a ETV1 inhibitor,which inhibitor protein-protein interactions between ES-FLI1 and RHA.YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model.YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1.YK-4-279,prevents prostate cancer growth and metastasis in a mouse xenograft model.	price>
R-R-2771	VU0469650 CAS No.1443748-47-7	VU0469650/CAS No.1443748-47-7 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM.	price>
R-C-1072	CX-6258HCL CAS:1353859-00-3	CX-6258 HCl is a potent,orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM,25 nM and 16 nM for Pim1,Pim2,and Pim3.	price>
R-R-2772	ZJ43 CAS No.723331-20-2	ZJ43/CAS No.723331-20-2 is a potent NAAG peptidase inhibitor, with an IC50 of 2.4 nM and a Ki of 0.8 nM. ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models.	price>
R-C-1073	(R)-FL-118 CAS:151636-76-9	(R)-FL-118 is a derivative of Camptothecin(C175150),which is antitumor alkaloid that binds to the DNA-topoisomerase I complex,inhibiting the reassociation of DNA after cleavage by topoisomerase I,trapping the enzyme in a covalent linkage with DNA.	price>
R-R-2773	FEMA 4774 CAS No.1359963-68-0	FEMA 4774/CAS No.1359963-68-0 is a positive allosteric modulator of taste receptors T1R2 and T1R3, two subunits of the human sweet taste receptor. FEMA 4774 is also used as a sucrose sweetness enhancer.	price>
R-C-1074	TBA-354 CAS:1257426-19-9	TBA-354 is a potent anti-tuberculosis compound;maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates.	price>
R-R-2774	Pramlintide acetate CAS No.187887-46-3	Pramlintide acetate/CAS No.187887-46-3 is a polypeptide analogue of human amylin. Pramlintide acetate, an antidiabetic agent, is antineoplastic in colorectal cancer.	price>
R-C-1075	BMH-21 CAS：896705-16-1	BMH-21 is a potent small molecule DNA intercalator.BMH-21 binds ribosomal DNA and inhibits RNA polymerase I(Pol I)transcription.	price>
R-R-2775	a-CGRP (mouse, rat) (TFA)	α-CGRP (mouse, rat) TFA, a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) TFA can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) TFA has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies.	price>
R-C-1076	Poziotinib (HM781-36B) CAS：1092364-38-9	Poziotinib(HM781-36B)is an orally active,irreversible pan-HER inhibitor,which effectively inhibits EGFRwt,HER-2 and HER-4 with IC50s of 3.2, 5.3 and 23.5 nM, respectively.Poziotinib(HM781-36B)also shows excellent inhibitory activities against mutated EGFRs,including EGFRT790M and EGFRL858R/T790M,with IC50s of 4.2 and 2.2 nM,respectively.Excellent antitumor activity.	price>
R-R-2776	Cagrilintide acetate	Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies.	price>
R-C-1077	PF-431396 CAS：717906-29-1	PF-431396 hydrate has been used as a dual inhibitor of proline-rich tyrosine kinase 2(PYK2)/focal adhesion kinase(FAK)inhibitor to study its effects on phosphorylation of Yes-associated protein(YAP)at Ser127 and steady state of transcriptional coactivator with PDZ-binding motif(TAZ).It has also been used as a PYK2/FAK inhibitor to study its effects on protein kinase A activation in human sperm samples.	price>
R-R-2777	b-CGRP, human TFA	β-CGRP, human TFA (Human β-CGRP TFA) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.	price>

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