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Catalog	name	Description	price
R-C-1088	RN486 CAS：1242156-23-5	RN486 is a potently and selectively inhibitor.RN486 inhibited the Btk enzyme and displayed functional activities in human cell-based assays in multiple cell types.RN486 blocks Fcε receptor cross-linking-induced degranulation in mast cells (IC(50)=2.9 nM),Fcγ receptor engagement-mediated tumor necrosis factor α production in monocytes(IC(50)=7.0 nM),and B cell antigen receptor-induced expression of an activation marker,CD69,in B cells in whole blood(IC(50)=21.0 nM).RN486 produced robust anti-inflammatory and bone-protective effects in mouse CIA and rat adjuvant-induced arthritis(AIA) models.In the AIA model,RN486 inhibited both joint and systemic inflammation either alone or in combination with methotrexate,reducing both paw swelling and inflammatory markers in the blood.	price>
R-R-2788	Chrysin 6-C-glucoside 8-C-arabinoside CAS No.185145-34-0	Chrysin 6-C-glucoside 8-C-arabinoside/CAS No.185145-34-0 can inhibit the CGRP releasing and the activation of TRPV1 channel. Chrysin 6-C-glucoside 8-C-arabinoside can be used for anti-migraine research.	price>
R-C-1089	D4476 CAS:301836-43-1	D4476 is a relatively specific cell osmotic inhibitor of CK1 and ALK5 with IC50 values of 0.3 and 0.5,respectively μ In vitro,the phosphorylation of CK1 (casein kinase 1)was located at the serine residue near another phosphoserine in the multipoint phosphorylation domain(MPD).D4476 may be a competitive ATP inhibitor of CK1.In H4IIE cells,the site-specific phosphorylation of FOXO1a (ser322 and ser325)was inhibited at 50 and 125 μ M.The initial rate of nuclear repulsion is reduced.In HeLa cells,d4476 inhibited CK1 induced RhoB phosphorylation(ser185)at 50℃μ RhoB dependent actin fiber formation is then activated.D4476 treaCAS No.285986-88-1t resulted in partial p53 dependent growth arrest of HCT116 cells.	price>
R-R-2789	(3R,5R,6S)-Atogepant	(3R,5R,6S)-Atogepant ((3R,5R,6S)-MK-8031) is the enantiomer of Atogepant (HY-109022). Atogepant is a calcitonin gene-related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine.	price>
R-C-1090	CCG-1423 CAS：285986-88-1	CCG-1423 is a small-molecule inhibitor of RhoA transcriptional signaling.CCG-1423 potently(<1 mumol/L)inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells,and whereas it inhibits the growth of RhoC-overexpressing melanoma lines(A375M2 and SK-Mel-147)at nanomolar concentrations, it is less active on related lines(A375 and SK-Mel-28)that express lower levels of Rho.	price>
R-R-2790	R121919 CAS No.195055-03-9	R121919 (NBI30775)/CAS No.195055-03-9 is a potent and selective CRF1R antagonist with a Ki of 2 to 5 nM. R121919 has antidepressant and anxiolytic effects. R121919 alleviates defensive withdrawal in rats.	price>
R-C-1091	CP945598.HCl CAS：686347-12-6	CP 945598 hydrochloride(Otenabant HCl)is a potent and selective cannabinoid type 1 receptor antagonist that inhibits both basal and cannabinoid agonist-mediated CB(1)receptor signaling in vitro and in vivo.It displays low affinity for human CB2 receptors with Ki of 7600 nM. In vivo,CP-945598 reversed cannabinoid agonist-mediated responses,reduced food intake,and increased energy expenditure and fat oxidation in rodents.CP 945598 exhibits dose and concentration-dependent anorectic activity in two models of acute food intake in rodents,fast-induced re-feeding and spontaneous,nocturnal feeding.CP-945598 also acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat oxidation.	price>
R-R-2791	Verucerfont CAS No.885220-61-1	Verucerfont/CAS No.885220-61-1 is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively.	price>
R-C-1092	Citarinostat (ACY-241) CAS：1316215-12-9	Citarinostat(ACY-241,HDAC-IN-2)is an orally available selective HDAC6 inhibitor with IC50 of 2.6 nM and 46 nM for HDAC6 and HDAC3,respectively.It has 13 to 18-fold selectivity towards HDAC6 in comparison to HDAC1-3.	price>
R-R-2792	NBI-27914 CAS No.184241-44-9	NBI-27914/CAS No.184241-44-9 is a potent and selective antagonist of CRFR1. The CRF receptors, CRFR1 and CRFR2, are members of the G protein-coupled receptor superfamily.	price>
R-C-1093	SCR-1481 CAS:1174161-86-4	SCR-1481B1(c-Met inhibitor 2)is a potent compound that has activity against cancers dependent upon Met activation and also has activity against cancers as a VEGFR inhibitor.	price>
R-R-2793	[DPro5] Corticotropin Releasing Factor, human, rat TFA	[DPro5] Corticotropin Releasing Factor, human, rat TFA is a selective corticotropin releasing factor/hormone R2 (CRH-R2)agonist. [DPro5] Corticotropin Releasing Factor, human, rat TFA fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat.	price>
R-C-1094	BMS-777607 (BMS 817378) CAS:1025720-94-8	BMS-777607(BMS 817378)is a Met-related inhibitor for c-Met,Axl,Ron and Tyro3 with IC50 of 3.9 nM, 1.1 nM,1.8 nM and 4.3 nM in cell-free assays, 40-fold more selective for Met-related targets versus Lck,VEGFR-2,and TrkA/B, and more than 500-fold greater selectivity versus all other receptor and non receptor kinases.	price>
R-R-2794	Stressin I TFA	Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA is a potent CRF1 receptor selective agonist, Ki is 1.7 nM. Stressin I induces an increase in adrenocorticotropic hormone (ACTH) levels in rats.	price>
R-C-1095	TPT-260 Dihydrochloride CAS:2076-91-7	TPT-260 Dihydrochloride(NSC55712)is a thiophene thiourea derivative with molecule weight 260.00 in free base form;There is no formal name yet,we temporally call this molecule as TPT-260.	price>
R-R-2795	Pexacerfont CAS No.459856-18-9	Pexacerfont/CAS No.459856-18-9 is a selective corticotropin-releasing factor (CRF1) receptor antagonist with IC50 of 6.1±0.6 nM for human CRF1 receptor.	price>
R-C-1096	UNBS-5162 CAS: 956590-23-1	UNBS5162 is a pan-antagonist of CXCL chemokine expression with in vitro cytotoxic activity(IC50 range of 0.5-5 µM)against a range of human cancer cell lines including glioblastoma(Hs683 and U373MG),colorectal(HCT-15 and LoVo), non-small-cell lung(A549)and breast(MCF-7).	price>
R-R-2796	Antisauvagine-30 TFA	Antisauvagine-30 TFA (aSvg-30 TFA) is a potent, highly selective and competitive CRF2 receptor peptidic antagonist. Antisauvagine-30 TFA exhibits a Kd of 1.4 nM and 150 nM for mCRFR2β and CRFR1, respectively.	price>
R-C-1097	Omaveloxolone (RTA-408) CAS:1474034-05-3	Omaveloxolone(RTA 408)is an antioxidant inflammation modulator(AIM),which activates Nrf2 and suppresses nitric oxide(NO).Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.	price>
R-R-2797	Urocortin III, mouse TFA	Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics.	price>

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