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R-C-2817 Cholesterol-peg-galactose Cholesterol is an indispensable material for animal tissues and cells.It not only participates in the formation of cell membrane,but also is the raw material for the synthesis of bile acids,vitamin D and steroids.Galactose is a monosaccharide composed of six carbons and one aldehyde,which is classified as aldose and hexose. price>
R-R-2817 GLP-1R Antagonist 1 CAS No.488097-06-9 GLP-1R Antagonist 1 (compound 5d)/CAS No.488097-06-9 is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC50 of 650 nM. price>
R-C-1118 Defactinib(VS6063,PF-04554878) CAS:1073154-85-4 Defactinib(VS-6063;PF-04554878)is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities. price>
R-C-2818 PLL-PEG-Modified gold nanoparticles(5nm) Poly(L-lysine)is a light yellow powder with strong moisture absorption and slightly bitter taste.It is a linear polymer of lysine.Poly(L-lysine)is soluble in water and slightly soluble in ethanol. price>
R-R-2818 Cotadutide acetate Cotadutide (MEDI0382) acetate is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide acetate exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide acetate can be used in the research of obesity and type 2 diabetes (T2D). price>
R-C-1119 Liproxstain-1 CAS :950455-15-9 Liproxstatin-1 is an iron droop inhibitor.At a concentration of 50 nm,GPx4-/- MEFs inhibited the iron drooping cell death(IC50=22 nm)and lipid peroxidation of mouse embryonic fibroblasts(MEFs)by inducible knockout of glutathione peroxidase 4(GPx4-/-MEFs).Liproxstatin-1 also inhibited the iron ptosis induced by iron ptosis inducers L-buthionine sulfoxime(BSO),erastine and (1s,3R)-rsl3 in a concentration dependent manner,but did not inhibit necrotic ptosis,apoptosis or necrosis.Inhibition of(1s,3R)-rsl3 induced cell death and lipid peroxidation in human renal proximal tubular epithelial cells.Liproxstatin-1 (10mg/kg)increased survival rate and decreased TUNEL+renal cells in induced GPx4 -/-mice,and reduced tissue damage in liver ischemia/reperfusion injury mice.It is also an antioxidant that inhibits lipid autoxidation by capturing peroxyradicals. price>
R-C-2819 Red fluorescence of carbon quantum dots Carbon quantum dots not only have the common fluorescence characteristics of quantum dots,but also have good stability and high biocompatibility.They are widely used in biomedical fields, such as cell labeling,optical imaging,drug delivery and biosensor. price>
R-R-2819 Beinaglutide CAS No.123475-27-4 Beinaglutide/CAS No.123475-27-4 is a human GLP-1 polypeptide that shares almost 100% homology with human GLP-1 (7–36). Beinaglutide displays does-dependent effects in glycemic control, inhibiting food intake and gastric empty and promoting weight loss. Beinaglutide has the potential for the research of overweight/obesity and nonalcoholic steatohepatitis (NASH). price>
R-C-1120 Radotinib(IY-5511) CAS:926037-48-1 Radotinib is a selective second generation tyrosine kinase inhibitor that targets both the wild-type and mutant forms of Bcr-Abl,with an IC50 value of 30.6 nM in Ba/F3 human chronic myeloid leukemia cells expressing the wild-type form.Radotinib also inhibits platelet-derived growth factor receptors(PDGFRs)α and β with IC50 values of 75.5 and 130 nM,respectively.Binding of radotinib to Bcr-Abl in vitro inhibits the phosphorylation of the downstream signaling mediator CrkL.3 In acute myeloid leukemia cells,in vitro treatment with radotinib at doses of 10-100 µM reduces viability,activates the mitochondrial apoptosis pathway,and promotes expression of the differentiation marker CD11b. price>
R-C-2820 Green fluorescence of carbon quantum dots Carbon quantum dots not only have the common fluorescence characteristics of quantum dots,but also have good stability and high biocompatibility.They are widely used in biomedical fields,such as cell labeling, optical imaging,drug delivery and biosensor. price>
R-R-2820 GLP-2(1-33)(human) CAS No.223460-79-5 GLP-2(1-33) (human)/CAS No.223460-79-5 is an enteroendocrine hormone which can bind to the GLP-2 receptor and stimulate the growth of intestinal epithelium. price>
R-C-1121 SKF-86002 CAS:72873-74-6 SKF-86002 is an orally active p38 MAPK inhibitor,with anti-inflammatory,anti-arthritic and analgesic activities.SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. price>
R-C-2821 CY5-Black phosphorus nanoparticles(100nm) Black phosphorus,a new two-dimensional nano material, has excellent photothermal properties and biodegradability.It is a potential drug carrier material.It has good solvent dispersion(water,acetone,alcohols,NMP,DMF,etc.) and relatively high singlet oxygen quantum yield (about 0.91). price>
R-R-2821 Lotiglipron CAS No.2401892-75-7 Lotiglipron (PF-07081532)/CAS No.2401892-75-7 is an orally active GLP-1R agonist. Lotiglipron reduces glucose and body weight, and can be used for research of Type 2 diabetes mellitus (T2DM). price>
R-C-1122 EPZ015666 (GSK3235025) CAS:1616391-65-1 Protein arginine methyltransferases(PRMTs)target nuclear and cytoplasmic substrates and can alter protein actions and gene expression.PRMT5,which can methylate histones H2A,H3,and H4,ribonucleoproteins,and other proteins,is upregulated in several human cancers,including lymphomas.Moreover,suppression of PRMT5 expression induces lymphoma cell death.EPZ015666 is a potent,orally bioavailable inhibitor of PRMT5(Ki=5nM).It displays more than 20,000-fold selectivity for PRMT5 over other PMTs.EPZ015666 acts by blocking the association of PRMT5 with methylosome protein 50,which is necessary for the formation of an active methyltransferase complex. price>
R-C-2822 PLL5k-g-PEG5k-MAL Polylysine linked polyethylene glycol.and the other end of polyethylene glycol modified maleimide.It can be used for passive targeting of micelles and vesicles,active targeting research and drug delivery. price>
R-R-2822 Exendin-4 acetate CAS No.914454-01-6 Exendin-4 acetate (Exenatide acetate)/CAS No.914454-01-6, a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM. price>
R-C-1123 Dorsomorphin (Compound C) 2HCl Dorsomorphin 2HCl(BML-275,Compound C)is a potent,reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays,exhibiting no significant inhibition of several structurally related kinases including ZAPK,SYK,PKCθ, PKA,and JAK3.Also inhibits type Ⅰ BMP receptor activity.Dorsomorphin induces autophagy in cancer cell line. price>
R-C-2823 Yeast glucan-Schiff Base-PEI25K-FITC Yeast glucan is a polysaccharide with immune enhancing activity in yeast cell wall β-Dextran.β- Glucan widely exists in various fungi and plants,such as yeast,Lentinus edodes,Ganoderma lucidum and oats.It is the main functional substance for them to play a role in health care. Schiff base mainly refers to a class of organic compounds containing imine or methylimine characteristic groups(-RC=n-).Usually,Schiff base is formed by condensation of amine and active carbonyl It has excellent liquid crystal properties.Used as organic synthetic reagent and liquid crystal material. price>
R-R-2823 Retatrutide TFA Retatrutide (LY3437943) TFA is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide TFA binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide TFA can be used for the research of obesity. price>