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R-C-2844 DSPE-SS-Mercaptopyridine Mercaptopyridine and pyridinrthiols have two isomers.2-Ryukyipizha is soluble in water,ethanol,benzene and chloroform.Its N-oxide melting point is B7. price>
R-R-2844 LSN3318839 CAS No.2764704-18-7 LSN3318839/CAS No.2764704-18-7 is an orally efficacious positive allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R). price>
R-C-1145 3-Cyano-7-ethoxycoumarin CAS:117620-77-6 3-Cyano-7-ethoxycoumarin is a fluorogenic substrate suitable for the continuous determination of cytochrome P450 mixed-function monooxygenases.It is a fluorescent probe useful in microsomal dealkylase studies. price>
R-C-2845 Azithromycin limonamide tobramycin Azithromycin is a semi synthetic 15 membered macrolide antibiotic.White or off white crystalline powder;Odorless and bitter;Slightly hygroscopic.Tobramycin is highly effective against Gram-negative bacteria,especially Pseudomonas aeruginosa. price>
R-R-2845 TT-OAD2 CAS No.2382719-60-8 TT-OAD2/CAS No.2382719-60-8 is a non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist with an EC50 of 5 nM. TT-OAD2 has the potential for diabetes treatment. price>
R-C-1146 BIX01294 HCl CAS:1392399-03-9 BIX01294 is a potent chemical inhibitor of G9a methyltransferase that catalyzes the mono-and di-methylation of the lysine 9 residue of histone H3.BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7cells. BIX01294 enhances the cardiac potential of bone marrow cells. price>
R-C-2846 glycyrrhetic acid-PEG-hyd-PLGA Cell information transmission and gene expression Glycyrrhizic acid has inhibitory effect on experimental animal malignant tumor bacteria induced by a variety of carcinogens Glycyrrhetinic acid also has the effect of antiviral infection,and EB virus and HIV infection are all inhibited. price>
R-R-2846 GLP-1R modulator C5 CAS No.421578-93-0 GLP-1R modulator C5/CAS No.421578-93-0 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM). price>
R-C-1147 ML204 CAS:5465-86-1 ML204 is a novel,potent,and selective TRPC4 channel inhibitor with apparent IC50 values of about 1 μM in fluorescent intracellular Ca2+ assays and about 3 μM in whole-cell voltage clamp experiments.It exhibits some selectivity within the TRPC subfamily of channels and higher selectivity against other TRP channels and non-TRP channels. price>
R-C-2847 SIB 1508Y maleate CAS:192231-16-6 Potent neuronal nicotinic ACh receptor agonist(EC50 values are 1.8,5,9 and 23 nM for α4β2,α2β4,α4β4 and α3β4 receptors respectively).Improves cognitive function in a MPTP-induced model of Parkinson Is Disease in vivo. price>
R-R-2847 GRA Ex-25 CAS No.307983-31-9 GRA Ex-25/CAS No.307983-31-9 is an inhibitor of glucagon receptor, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively. price>
R-C-1148 Purvalanol A CAS: 212844 Purvalanol A is a potent CDK inhibitor,which effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.indicating that the activation of CDKs contributes to the c-Src transformation.Purvalanol A suppressed the c-Src activity as effectively as the Src-selective inhibitor PP2,and that it reverted the transformed morphology to a nearly normal shape with less cytotoxicity than PP2.Purvalanol A induced a strong G2-M arrest,whereas PP2 weakly acted on the G1-S transition. price>
R-R-2848 Ecnoglutide CAS No.2459531-73-6 Ecnoglutide (XW003)/CAS No.2459531-73-6 is a long-acting, cAMP-biased glucagon-like peptide 1 (GLP-1) receptor agonist. Ecnoglutide can be used for research of T2DM and obesity. price>
R-C-1149 temsirolimus (CCI-779) CAS:162635-04-3 Temsirolimus is an ester analog of rapamycin.Temsirolimus binds to and inhibits the mammalian target of rapamycin(mTOR),resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle.mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors. price>
R-R-2849 Volagidemab CAS No.1233956-13-2 Volagidemab/CAS No.1233956-13-2 is an antagonistic glucagon receptor (GCGR) monoclonal antibody (mAb). Volagidemab can be used in the research of type 1 diabetes (T1D). price>
R-C-1150 DY-131 CAS:95167-41-2 DY131,also known as GSK-9089,is a novel selective agonist at estrogen-related receptors ERRβ and ERRγ.DY131 could potentiate the ERRgamma-induced growth inhibition in LNCaP-ERRgamma and DU145-ERRgamma cells in a dose-dependent manner.ERRgamma may perform an antiproliferative or tumor-suppressing function in prostate cancer cells. price>
R-R-2850 Survodutide TFA Survodutide (BI 456906) TFA is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide TFA, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide TFA has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake. price>
R-C-1151 Tafluprost CAS:209860-87-7 Tafluprost,also known as MK2452 and AFP-168,is a prostaglandin analogue used topically(as eye drops)to control the progression of glaucoma and in the management of ocular hypertension.It reduces intraocular pressure by increasing the outflow of aqueous fluid from the eyes. price>
R-R-2851 Glucagon-like peptide 1 (1-37), human TFA Glucagon-like peptide 1 (1-37), human (TFA) is a highly potent agonist of the GLP-1 receptor. price>
R-C-1152 SNG-1153 CAS:1446712-19-1 SNG-1153 is a modulator of estrogen receptor ER-alpha36. price>