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Catalog	name	Description	price
R-R-2922	GRK6-IN-1 CAS No.2677786-61-5	GRK6-IN-1 (compound 18)/CAS No.2677786-61-5 is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-1 has the potential for the research of multiple myeloma.	price>
R-C-1223	MHY1485 CAS：326914-06-1	MHY1485 is a mTOR activator;inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes.	price>
R-R-2923	GRK5-IN-2 CAS No.1642839-27-7	GRK5-IN-2 (compound 707)/CAS No.1642839-27-7, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor. GRK5-IN-2 regulates the expression and/or release of insulin and is useful for the metabolic disease research.	price>
R-C-1224	ELR510444 CAS：1233948-35-0	ELR510444 is a novel microtubule disruptor;inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM;not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell lines.	price>
R-R-2924	CCG258208 hydrochloride	CCG258208 (GRK2-IN-1) hydrochloride is a potent and selective GRK2 (G protein-coupled receptor kinase 2) inhibitor (IC50=30 nM) while maintaining 230-fold selectivity over GRK5 (IC50=7.09 μM) and more than 2500-fold selectivity over GRK1 (IC50=87.3 μM), PKA, and ROCK1. CCG258208 hydrochloride can be used in heart failure research.	price>
R-C-1225	AG-221 CAS:1446502-11-9	Enasidenib is an oral,potent,reversible,selective inhibitor of the IDH2 mutant enzymes,with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K,respectively.	price>
R-R-2925	GRK6-IN-2 CAS No.2677786-27-3	GRK6-IN-2 (compound 10a)/CAS No.2677786-27-3 is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for the research of multiple myeloma.	price>
R-C-1226	DBPR211 Cas:1429239-98-4	CB1-IN-1(also known as DBPR211)is a novel,potent,peripherally restricted antagonist of the CB1R(cannabinoid 1 receptor)with Ki values of 0.3 nM and 21 nM for CB1R(EC50 of 3 nM)and CB2R,respectively.CB1-IN-1 has shown significant weight-loss effects and can decrease hepatic steatosis as well as insulin resistance in a diet-induced obese mice model.Therefore,it has great potential to be used in this related metabolic syndrome such as obesity.It also has favorable PK profiles including an extremely low brain to plasma ratio suggesting a low probability to cross BBB.	price>
R-R-2926	CCG273441 CAS No.2750414-35-6	CCG273441/CAS No.2750414-35-6 is a covalent inhibitor of G protein-coupled receptor (GPCR) kinase 5 (GRK5) with an IC50 value of 3.8 nM. CCG273441 is highly selective to GRK5 over GRK2 (IC50=4.8 μM) by binding Cys474, a GRK5 subfamily-specific residue, as a covalent handle.	price>
R-C-1227	G007-LK CAS :1380672-07-0	G007-LK is a potent and selective inhibitor of TNKS1 and TNKS2,with IC50s of 46 nM and 25 nM,respectively.	price>
R-R-2927	KR-39038 CAS No.2770300-35-9	KR-39038/CAS No.2770300-35-9 is an orally active and potent GRK5 (G protein-coupled receptor kinase 5) inhibitor, with an IC50 of 0.02 μM. KR-39038 significantly inhibits angiotensin II-induced cellular hypertrophy through suppression of HDAC5 pathway in neonatal cardiomyocytes. KR-39038 shows profound anti-hypertrophic effects and improved cardiac function. KR-39038 can be used for heart failure research.	price>
R-C-1228	KU60019 CAS: 925701-49-1	KU-60019 is an improved analogue of KU-55933,with IC50 of 6.3 nM for ATM in cell-free assays,270-and 1600-fold more selective for ATM than DNA-PK and ATR,and is a highly effective radiosensitizer.	price>
R-R-2928	GRK2i TFA	GRK2i TFA is a GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. GRK2i TFA corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.	price>
R-C-1229	GSK8573 CAS :1693766-04-9	GSK8573(compound 23)is an inactive control compound for GSK2801.GSK8573 has binding activity to BRD9 with a Kd value of 1.04 μM and is inactive against BAZ2A/B and other bromodomain familiy.	price>
R-R-2929	Lificiguat CAS No.170632-47-0	Lificiguat/CAS No.170632-47-0 binds to the β subunit of soluble guanylyl cyclase(sGC) with Kd of 0.6-1.1 μM in the presence of CO.	price>
R-C-1230	SAR405838 (MI-773) CAS:1303607-60-4	SAR405838 is a highly potent and selective MDM2 inhibitor,binds to MDM2 with Ki= 0.88 nM and has high specificity over other proteins.	price>
R-R-2930	Vericiguat CAS No.1350653-20-1	Vericiguat (BAY1021189)/CAS No.1350653-20-1 is a potent, orally available and soluble guanylate cyclase stimulator.	price>
R-C-1231	10058-F4 CAS No. 403811-55-2	10058-F4 is a potent and selective c-Myc inhibitor,which markedly increases valproic acid-induced cell death in Jurkat and CCRF-CEM T-lymphoblastic leukemia cells.10058-F4 inhibits proliferation,downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells.10058-F4 induces cell-cycle arrest,apoptosis,and myeloid differentiation of human acute myeloid leukemia.	price>
R-R-2931	Linaclotide CAS No.851199-59-2	Linaclotide/CAS No.851199-59-2 is a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation.	price>
R-C-1232	Lomeguqtrib CAS:192441-08-0	Lomeguatrib,also known as PaTrin-2,is a potent Inhibitor of O6-Alkylguanine-DNA-Alkyltransferase.Lomeguatrib is also a nontoxic low-molecular weight pseudosubstrate that has the ability to inactivate MGMT.Lomeguatrib can be used with temozolomide(TMZ)for GBM treatment.	price>

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