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Catalog	name	Description	price
R-R-2932	Cinaciguat CAS No.329773-35-5	Cinaciguat/CAS No.329773-35-5 is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure.	price>
R-C-1233	AZD1981 CAS:802904-66-1	AZD1981is an orally available selective CRTH or DP2 antagonist currently in clinical development for asthma.AZD1981 blocks functional responses in eosinophils,Th2 cells and basophils.AZD1981 displaced radio-labelled PGD2 from human recombinant DP2 with high potency(pIC50=8.4).Binding was reversible,non-competitive and highly selective against a panel of more than 340 other enzymes and receptors,including DP1(>1000-fold selective).AZD1981 inhibited DP2-mediated shape change and CD11b up-regulation in human eosinophils,shape change in basophils and chemotaxis of human eosinophils and Th2 cells with similar potency.AZD1981 exhibited good cross-species binding activity against mouse,rat,guinea pig,rabbit and dog DP2.Evaluation in mouse,rat or rabbit cell systems was not possible as they did not respond to DP2 agonists.Agonist responses were seen in guinea pig and dog, and AZD1981 blocked DP2-mediated eosinophil shape change.Such responses were more robust in the guinea pig,where AZD1981 also blocked DP2 -dependent eosinophil emigration from bone marrow.	price>
R-R-2933	ODQ CAS No.41443-28-1	ODQ/CAS No.41443-28-1 is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells.	price>
R-C-1234	Blonanserin CAS:132810-10-7	Blonanserin(AD-5423)is a potent and orally active 5-HT2A(Ki=0.812 nM) and dopamine D2 receptor(Ki=0.142nM)antagonist.Blonanserin is usually acts as an atypical antipsychotic agent and can be used for the research of extrapyramidal symptoms,excessive sedation,or hypotension.	price>
R-R-2934	BAY 41-2272 CAS No.256376-24-6	BAY 41-2272/CAS No.256376-24-6 is an orally active and soluble guanylate cyclases (sGC) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research.	price>
R-C-1235	BRD73954 CAS:1440209-96-0	BRD73954 is a small molecule inhibitor that potently inhibits HDAC6 and HDAC8. It inhibits HDAC6,a class IIb histone that deacetylates cytoplasmic proteins, including tubulin,heat shock protein 90,and cortactin,and has roles in cell adhesion and motility.It is also an inhibitor of HDAC8,a class I histone that primarily targets nuclear proteins,including histones and cohesins,and regulates gene expression.	price>
R-R-2935	BAY 60-2770 CAS No.1027642-43-8	BAY 60-2770/CAS No.1027642-43-8 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect.	price>
R-C-1236	STF-118804 CAS: 894187-61-2	STF 118804 is a highly specific NAMPT inhibitor that reduces the viability of most B-ALL cell lines with high potency IC50 values in the low nanomolar range and improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia.	price>
R-R-2936	Runcaciguat CAS No.1402936-61-1	Runcaciguat/CAS No.1402936-61-1 is an orally active stimulator of soluble guanylate cyclase, and is used in the research of cardiovascular and renal diseases combined with selective partial adenosine A1 receptor agonists.	price>
R-C-1237	Spautin-1 CAS:1262888-28-7	Spautin-1 is a novel autophagy inhibitor,IM inhibited the growth of K562 cells with IC50 of 1.03μM.In contrast,co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM.	price>
R-R-2937	NS-2028 CAS No.204326-43-2	NS-2028/CAS No.204326-43-2 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC50 values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity. NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase with IC50 values of 17 nM and 20 nM. NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells with an IC50 of 30 nM. NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM). NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability.	price>
R-C-1238	ONC201(TIC10) CAS:1616632-77-9	TIC10 is a potent,orally active,and stable tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)inducer which acts by inhibiting Akt and ERK, consequently activating Foxo3a and significantly inducing cell surface TRAIL. TIC10 can cross the blood-brain barrier.	price>
R-R-2938	Ataciguat CAS No.254877-67-3	Ataciguat (HMR-1766)/CAS No.254877-67-3 is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects.	price>
R-C-1239	R1487 Hydrochloride CAS:449808-64-4	R1487 Hydrochloride is a highly potent and selective p38αinhibitor, with Kd values of 0.2 nM and 29 nM for p38α and p38β,respectively.	price>
R-C-2239	Oroxin B CAS：114482-86-9	Oroxin B(OB)is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.)Vent.Oroxin B(OB)possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN,down regulation of COX-2,VEGF,PI3K,and p-AKT.	price>
R-R-2939	Cinaciguat hydrochloride CAS No.646995-35-9	Cinaciguat hydrochloride/CAS No.646995-35-9 is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.	price>
R-C-1240	GSK2256098 CAS:1224887-10-8	GSK2256098,also known as GTPL7939,is a focal adhesion kinase-1(FAK)inhibitor with potential antiangiogenic and antineoplastic activities.FAK inhibitor GSK2256098 inhibits FAK,which may prevent the integrin-mediated activation of several downstream signal transduction pathways,including ERK,JNK/MAPK and PI3K/Akt,thereby inhibiting tumor cell migration,proliferation and survival,and tumor angiogenesis.The tyrosine kinase FAK is normally activated by binding to integrins in the extracellular matrix(ECM)but may be upregulated and constitutively activated in various tumor cell types.	price>
R-R-2940	Praliciguat CAS No.1628730-49-3	Praliciguat (IW-1973)/CAS No.1628730-49-3 is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC50 of 197 nM.	price>
R-C-1241	Cobimetinib(gdc0973,XL518,RG7420) CAS No. 934660-93-2	Cobimetinib (GDC-0973,RG7420)is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM,showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.Cobimetinib induces apoptosis.	price>
R-R-2941	Olinciguat CAS No.1628732-62-6	Olinciguat (IW-1701)/CAS No.1628732-62-6 is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay.	price>

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